Et3N- Promoted Cascade Sp3C-H Bond Functionalization of Methyl Arene with Active Methylene CompoundsUnder Solvent-Free Condition

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We investigate L-Tyrosine as an efficient catalyst for the Knoevenagel condensation of arylaldehydes with meldrum’s acid containing cyclic active methylene group in solvent-free condition under grindstone method at room temperature to produce substituted-5-benzylidene-2,2-dimethyl-[1,3]dioxane-4,6-diones 3(a–j).


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