DBU‐Promoted Synthesis of 1,3‐Benzoxazines from Geminal Dibromo Olefins: Applications to the Construction of o ‐Amido Phenacyl Bromides

2020 ◽  
Vol 5 (13) ◽  
pp. 3778-3783
Author(s):  
Amol Milind Garkhedkar ◽  
Ya‐Chi Chiang ◽  
Gopal Chandru Senadi ◽  
Jeh‐Jeng Wang ◽  
Wan‐Ping Hu
Keyword(s):  
Phenacyl Bromides

Diminished Reactivity of Ortho-Substituted Phenacyl Bromides toward Nucleophilic Displacement

2003 ◽  
Vol 68 (4) ◽  
pp. 1594-1596 ◽  
Author(s):  
Diane M. Kalendra ◽  
Barry R. Sickles
Keyword(s):  
Nucleophilic Displacement ◽  
Phenacyl Bromides

Kinetics of the reactions of phenacyl bromide and of pare-substituted phenacyl bromides with benzoate and substituted trans-cinnamate ions

1985 ◽  
pp. 17 ◽  
Author(s):  
Chockalingam Srinivasan ◽  
Arunachalam Shunmugasundaram ◽  
Natasan Arumugam
Keyword(s):  
Phenacyl Bromide ◽  
Phenacyl Bromides ◽  
Kinetics Of

Palladium-catalyzed paraformaldehyde insertion: a three-component synthesis of benzofurans

2016 ◽  
Vol 14 (10) ◽  
pp. 2819-2823 ◽  
Author(s):  
Xiufang Cheng ◽  
Yi Peng ◽  
Jun Wu ◽  
Guo-Jun Deng
Keyword(s):  
Palladium Catalysis ◽  
Phenacyl Bromides ◽  
Palladium Catalyzed

2-Aroylbenzofurans were prepared from 2-bromophenols, phenacyl bromides and paraformaldehyde under palladium catalysis conditions.

Phenacyl bromides as chromophoric reagents for α-chymotrypsin

Biochemistry ◽  
1969 ◽  
Vol 8 (11) ◽  
pp. 4560-4566 ◽  
Author(s):  
D. S. Sigman ◽  
D. A. Torchia ◽  
E. R. Blout
Keyword(s):  
Phenacyl Bromides

scholarly journals Synthesis and anticonvulsant activity of 6-methyl-2-((2-oxo-2-arylethyl)thio)pyrimidin-4(3 H)-one derivatives and products of their cyclization

Pharmacia ◽  
2019 ◽  
Vol 66 (3) ◽  
pp. 141-146
Author(s):  
Hanna Severina ◽  
Olga O. Skupa ◽  
Natalya I. Voloshchuk ◽  
Marharyta M. Suleiman ◽  
Victoriya A. Georgiyants
Keyword(s):  
Sulphuric Acid ◽  
Anticonvulsant Activity ◽  
Sodium Methoxide ◽  
Structure Activity ◽  
Phenacyl Bromides ◽  
Pharmacological Screening ◽  
High Yields ◽  
Derivatives Of

The alkylation of 6-methyl-2-thioxo-2,3-dihydro-1H-pyrimidine-4-one phenacyl bromides under different conditions was investigated. It was found that during the reaction in the medium of DMF/K2CO3 a mixture of 2-(2-aryl-2-oxoethyl)thio-6-methyl-pyrimidine-4(3H)-one and 3-hydroxy-3-aryl-7-methyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-5-one was formed. The holding of the resulting mixture in the concentrated sulphuric acid leads to the formation of cyclization products - derivatives of 3-aryl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one with high yields. Individual S-alkylated derivatives – 2-(2-aryl-2-oxoethyl)thio-6-methyl-pyrimidine-4(3H)-one - were obtained by reacting in methanol in the presence of sodium methoxide. Pharmacological screening of synthesized compounds for anticonvulsant activity on the model of pentylenetetrazole seizures in rats was carried out and some regularity “structure-activity” was established.

Reaction of Phenacyl Bromides with Selenium Powder

2008 ◽  
pp. 1
Author(s):  
T. Shimizu ◽  
N. Kamigata
Keyword(s):  
Phenacyl Bromides

ChemInform Abstract: PREPARATION OF SOME RING-OXYGENATED PHENACYL BROMIDES

1979 ◽  
Vol 10 (10) ◽  
Author(s):  
T. FUJII ◽  
S. YOSHIFUJI ◽  
M. OHBA
Keyword(s):  
Phenacyl Bromides

Carbon-13 NMR spectra of some 4-substituted phenacyl bromides

1984 ◽  
Vol 22 (3) ◽  
pp. 199-199 ◽  
Author(s):  
Fred Yukio Fujiwara ◽  
Roberto Rittner ◽  
Haydeé R. Freire
Keyword(s):  
Nmr Spectra ◽  
Phenacyl Bromides

ChemInform Abstract: REACTIONS OF SUBSTITUTED PHENACYL BROMIDES WITH VARIOUS BASES. O- AND P-NITROPHENACYL BROMIDE. I

1985 ◽  
Vol 16 (1) ◽  
Author(s):  
J. H. SCOTT ◽  
T. A. SMITH ◽  
J. H. HUTCHINSON
Keyword(s):  
Phenacyl Bromides

scholarly journals Phenacylation of 6-Methyl-Beta-Nitropyridin-2-Ones and Further Heterocyclization of Products

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1682
Author(s):  
Eugene V. Babaev ◽  
Victor B. Rybakov
Keyword(s):  
Pyridinium Salt ◽  
Phenacyl Bromides ◽  
Acidic Conditions ◽  
Phenacyl Derivatives ◽  
Derivatives Of

Reaction between the derivatives of 6-methyl-beta-nitropyridin-2-one and phenacyl bromides was studied, and the yields observed were extremely low. The pyridones were converted via chloropyridines to methoxyderivatives, which were N-phenacylated. N-Phenacyl derivatives of 4,6-dimethyl-5-nitropyridin-2-one under the action of base gave 5-hydroxy-8-nitroindolizine and under acidic conditions gave 5-methyl-6-nitrooxazole[3,2-a]pyridinium salt, which underwent recycization with MeONa to 5-methoxy-8-nitroindolizine.

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