Two Routes for the Synthesis of Phosphorothioates via P‐S Coupling Reaction of Dialkyl Phosphites with Thiols or a Mixture of Alkyl Halides and Thiourea in the Presence of CaO

2020 ◽  
Vol 5 (28) ◽  
pp. 8717-8721
Author(s):  
Babak Kaboudin ◽  
Fariba Noori ◽  
Leila Dehghani ◽  
Sajedeh Alavi ◽  
Foad Kazemi
Keyword(s):  
Coupling Reaction ◽  
Alkyl Halides ◽  
Dialkyl Phosphites

Nickel-Catalyzed Multicomponent Coupling Reaction of Alkyl Halides, Isocyanides and H2O: An Expedient Way to Access Alkyl Amides

Synthesis ◽  
2020 ◽  
Vol 52 (22) ◽  
pp. 3466-3472
Author(s):  
Yunkui Liu ◽  
Bingwei Zhou ◽  
Qiao Li ◽  
Hongwei Jin
Keyword(s):  
Functional Group ◽  
Coupling Reaction ◽  
Alkyl Halides ◽  
Previous Literature ◽  
Catalytic Cycle ◽  
Reaction Conditions ◽  
Multicomponent Coupling ◽  
Easy Operation

We herein describe a Ni-catalyzed multicomponent coupling reaction of alkyl halides, isocyanides, and H2O to access alkyl amides. Bench-stable NiCl2(dppp) is competent to initiate this transformation under mild reaction conditions, thus allowing easy operation and adding practical value. Substrate scope studies revealed a broad functional group tolerance and generality of primary and secondary alkyl halides in this protocol. A plausible catalytic cycle via a SET process is proposed based on preliminary experiments and previous literature.

Nickel-Catalyzed Regioselective Three Component Coupling Reaction of Alkyl Halides, Butadienes, and Ar-M (M=MgX, ZnX)

2004 ◽  
Vol 346 (8) ◽  
pp. 905-908 ◽  
Author(s):  
Jun Terao ◽  
Shinsuke Nii ◽  
Firoz A. Chowdhury ◽  
Akifumi Nakamura ◽  
Nobuaki Kambe
Keyword(s):  
Coupling Reaction ◽  
Alkyl Halides ◽  
Three Component Coupling

Copper-Catalyzed Cross-Coupling Reaction of Grignard Reagents with Primary-Alkyl Halides: Remarkable Effect of 1-Phenylpropyne

2007 ◽  
Vol 119 (12) ◽  
pp. 2132-2135 ◽  
Author(s):  
Jun Terao ◽  
Hirohisa Todo ◽  
Shameem Ara Begum ◽  
Hitoshi Kuniyasu ◽  
Nobuaki Kambe
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
Alkyl Halides ◽  
Grignard Reagents ◽  
Remarkable Effect ◽  
Cross Coupling Reaction
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