Effect of Processing Parameters On Mechanical Properties of Inconel718 Superalloy Fabricated By Direct Energy Deposit

In this study, Inconel718 specimens with good mechanical properties were prepared by direct energy deposit (DED) with different laser processing parameters. The mechanical properties of Inconel718 samples fabricated by laser direct energy deposit method without heat treatment were measured. The fractures and metallographic structures of prepared Inconel718 were observed, and the mechanism of the effect of diverse machining parameters on mechanical properties of Inconel718 was analyzed from the micro level. The results showed the microstructures of depositions of Inconel 718 specimens prepared by DED were compact with fine grains and anisotropic microstructures, where macroscopic defects were barely seen. The mechanical properties and microstructures of Inconel718 were influenced by processing parameters, among which the forming angle and laser power had the most remarkable effect. According to the experimental data, it could be observed that the Inconel718 specimens prepared by DED had the best performance under the circumstance of 1400W laser power, 1.0mm layer thickness, 600mm/min scanning speed, 1.3mm hatch spacing, and 90° forming angle, whose ultimate tensile strength (UTS) and macro hardness were 1016.10MPa and 36.2HRC respectively. The UTS of Inconel 718 manufactured by DED was close to that of Inconel718 prepared by traditional forging, and even it had higher hardness.

The Potential Effect of Silver Nanoparticles on the Expression and Levels of Skin Matrix Metalloproteinases (Gelatinases): In Vivo Assessment

The current work aimed to investigate the enzymatic activities and the expression profiles of the metalloproteinases MMP-2 and MMP-9 in the skin of rabbits as an animal model, upon sub-acute dermal exposure to Ag-NPs. This was done in order to determine their potential effect on these proteolytic enzymes which have been traditionally involved in many physiological processes such as inflammation and wound healing which are among the main applications Ag-NPs containing medical products. The rabbits were topically exposed to every other day dose of 0.5% Ag-NPs for 7- and 14-days experimental periods. Both periods were followed by 7 days recovery time. The results revealed the remarkable effect of Ag-NPs on MMPs at both the enzyme production and the transcriptional levels. The effect was time dependent where no significant changes were found after the 7 days of exposure, while the concentrations of MMP-2 and MMP-9 as well as the expression of their encoding genes were significantly elevated in the skin of the exposure and recovery groups at the 14 days experimental period. MMP-9 was the most affected enzyme, whereas MMP-2 showed the minimal effect. Several mechanisms and pathways have been suggested to explain the disturbance of MMPs which require further molecular studies to obtain more evidence supporting the most probable explanation.

Investigation of H2S Solubility in Aqueous N- Methyldiethanolamine + Amine Functionalized UiO-66 as a nano solvent

In this paper, the experimental solubility of hydrogen sulfide in aqueous N- Methyldiethanolamine + Amine Functionalized UiO-66 (UiO-66-NH2) was studied. UiO-66-NH2 was produced using solvothermal process, and its physicochemical properties were investigated by different techniques including XRD, TGA, TEM, BET, and FTIR to realize its crystalline structure, morphology, thermal stability, and porous structure. The Zeta potential of the solution was turned out to be about 26.6 mV (millivolt), meaning that UiO-66-NH2 particles are moderately stable in aqueous 40 wt.% MDEA. The solubility of hydrogen sulfide has been carried out using the isochoric saturation / or static method in two concentration grades of 0.1 and 0.5 wt.% of UiO-66-NH2 in the aqueous solution of 40 wt.% MDEA known as nanofluid. Experimental measurements were carried out at temperatures of 303.15 through 333.15 K, and pressures up 1100 kPa. Results showed that the addition of UiO-66-NH2 nanoparticles to the MDEA solution altered the results less than 3% , while the mean value of uncertainty reported in this work is about 4% , meaning that the addition of nanoparticles do not have remarkable effect on H2S solubility. In contrast, it causes an increased capacity of CO2 absorption of that solution up to 10% .

The Valorization of Biolignin from Esparto Grass (Stipa tenacissima L.) Produced by Green Process CIMV (Compagnie Industrielle de la Matière Végétale) for Fertilization of Algerian Degraded Soil: Impact on the Physicochemical and Biological Properties

This study proposes a new use for a paper industry waste material, lignin, in agriculture and agronomy as a fertilizer for arid soils, while following a strategy aiming to both increase the amount of organic matter in these soils and decrease the impact of pollution caused by industrial discharges that contain organic and/or inorganic pollutants generated by the paper industry. In fact, this method works to improve soil quality through a new carbon-rich bioorganic fertilizer (biolignin) that results from a green method called CIMV, a targeted depollution objective of the paper industry. Over the course of 180 days, we monitored the physicochemical and biological characteristics of degraded soils treated with three different biolignin treatments of 0 (D0), 2 (D1), and 4 (D2) g/kg. The humification was then evaluated by the equation E4/E6. A remarkable variation of the physicochemical and biological parameters was observed in D1 and D2: temperature 12–38 °C, humidity 9–29%, and pH 7.06–8.73. The C/N ratio decreased from 266 to 49. After 180 days, the improvement in soil carbon content for the three treatments D0, D1, and D2 was 14%, 19%, and 24%, respectively. A maximum bacterial biomass of 152 (CFU/g soil) was observed on the 30th day for D1. Maximum laccase activity for D2 was observed on the 120th day. D1 and D2 recorded a significant degree of humification compared to D0. The best indicator of humification E4/E6 was observed in D1, where the value reached 2.66 at the end of the treatment period. The D2 treatment showed a remarkable effect improving the fertility of the degraded soil, which confirms that biolignin is a good fertilizer.

Using side flow jets as a scour countermeasure downstream of a sluice gate

Background Local scour is one of the main problems affecting the stability and operation of control hydraulic structures. Many techniques were used to control the resulting scour. In the recent study, a new technique was used to control local scour downstream single-gate hydraulic regulator by using side flow jets. This study aimed to demonstrate the effect of side jets at different angles on the local scour parameters (depth, length, and volume) and energy dissipation in the downstream hydraulic regulator. Results A physical model was used to represent the open channel, regulator, and the side jets with different angles. Five flow discharges, four jet angles, and three gate openings were applied through the experiment. The experiment results showed that the presence of side jets had a remarkable effect on the parameters of the local scour hole and energy dissipation. They dissipated more energy of hydraulic jump than in the absence of jets, and consequently, scour hole dimensions were significantly reduced. Regression analysis was used to deduce equations that can predict the development of local scour downstream sluice gate considering the inclination angle of side flow jets under different flow conditions. Conclusions Side flow jets can be used as scour reducer techniques with the advantages of eliminating the jet clog produced from sediments and suspended solids.

Optimization of metabolism to improve efficacy during CAR-T cell manufacturing

Chimeric antigen receptor T cell (CAR-T cell) therapy is a relatively new, effective, and rapidly evolving therapeutic for adoptive immunotherapies. Although it has achieved remarkable effect in hematological malignancies, there are some problems that remain to be resolved. For example, there are high recurrence rates and poor efficacy in solid tumors. In this review, we first briefly describe the metabolic re-editing of T cells and the changes in metabolism during the preparation of CAR-T cells. Furthermore, we summarize the latest developments and newest strategies to improve the metabolic adaptability and antitumor activity of CAR-T cells in vitro and in vivo.

Application Effect of Nurse Patient Communication in Oncology Nursing

Objective: To explore the clinical significance of strengthening nurse patient communication in oncology department. Methods: The study was carried out in our hospital. Taking 100 patients selected from May 2020 to May 2021 as an example, all patients were cancer patients. When they were treated, they cooperated with nursing, carried out grouping experiments, adopted different nursing methods, and compared and analyzed the recovery of patients under different nursing interventions. Results: There were significant differences in nursing satisfaction and compliance between the experimental group and the control group, expressed as P < 0.05. In contrast, the experimental group had higher satisfaction, better compliance and better effect. Conclusion: Strengthening nurse patient communication in oncology patients is helpful to improve patients’ understanding, improve patients’ bad mood and promote patients’ compliance. It has positive significance and remarkable effect on patients.

Growth Performance and Intestinal Morphometric Features of Broiler Chickens Fed on Dietary Inclusion of Yellow Mealworm (Tenebrio Molitor), Larvae Powder

Climate change and the lack of conventional feed ingredients have made edible insects a highly nutritious alternative to feed production. The use of insects as food may help solve socio-economic and environmental problems around the world and be in line with the United Nations Sustainable Development Goals. In this study, the growth performance and intestinal morphology of broiler chickens were evaluated under the influence of adding different levels of Tenebrio molitor larvae meal (TM meal) to their diets. One hundred eighty day-old broiler chickens were divided into 3 treatments and 5 replications (12 chickens/pen). The experimental diets included a control diet and treatments containing 2.5 and 5% TM meal, which were fed to birds in the starter (0-10 days) and grower (11-25 days) stages, and during the final period (26-42 days), all birds were fed a regular finisher diet. The results showed that the diet containing TM meal had no remarkable effect on the mortality rate and feed intake (FI) of broilers (P > 0.05). In the period of starter, the addition of 2.5% TM meal to broilers diet increased body weight gain (BWG) than the control group (P £ 0.05). Also, the use of 2.5% TM meal in the starter period showed a significant effect on reducing the feed conversion ratio (FCR) compared to the birds fed by the control diet (P £ 0.05). Besides, the height of the villus, the depth of the crypt, and the ratio of them were not altered among the different treatments (P > 0.05). Overall, it can be concluded that TM meal could improve growth performance in the starter period, and had no negative effects on broilers' performance and intestinal morphology in all the periods of the experiment.

Stem Cells Therapy for COVID-19: A Systematic Review and Meta-Analysis

Introduction: Vaccination seems to be a good solution for preventing and controlling coronavirus disease (COVID-19) pandemic, but still there are some challenges in COVID-19 vaccination. Investigating new therapeutic options for COVID-19 is necessary. The current study aimed to evaluate the safety and efficacy of stem cells in treating patients with COVID-19.Methods: We reviewed the relevant scientific literature published up to April 1, 2021. The pooled risk ratio (RR) with 95% CI was assessed using a fixed or random-effect model. We considered P &lt; 0.05 as statistically significant for publication bias. Data were analyzed by Comprehensive Meta-Analysis software, Version 2.0 (Biostat, Englewood, NJ).Results: After reviewing 1,262 records, we identified 10 studies that met the inclusion criteria. The analysis showed that stem cell therapy could significantly reduce the mortality rate (RR 0.471, 95% CI: 0.270–0.821) and morbidity (RR 0.788, 95% CI: 0.626–0.992) in patients with COVID-19; compared with the control group.Conclusions: The present study suggests that stem cell therapy has a remarkable effect on reducing mortality and morbidity of patients with COVID-19. Further large-scale studies are needed to approve these results. Defining a protocol for stem cell therapy in patients with COVID-19 can lead to achieving the best clinical outcomes.