Transition Metal Catalyst Free Cross-Coupling Reaction of Tertiary Propargylic Alcohols with Hetero-Areneboronic Acids

We report a perfluorophenylboronic acid catalyzed cross coupling reaction of tertiary propargylic alcohols and hetero-areneboronic acids for valuable benzo[b]thiophene and cyclopenta[a]indene derivates. This coupling reaction proceeds efficiently with a wide array of substrates scope in up to 89% yield and excellent regioselectivity. A significant advantage of our protocol is the transition metal catalyst free and mild conditions needed. This strategy provides direct and facile access to medicinally important benzo[b]thiophene and cyclopenta[a]indene scaffold containing a quaternary carbon center.

Transition-Metal-Catalyzed Enantioselective Synthesis of Indoles from 2-Alkynylanilines

Optically active indole derivatives are ubiquitous in natural products and widely recognized as privileged components in pharmacologically relevant compounds. Therefore, developing catalytic asymmetric approaches for constructing indole derivatives is highly desirable. In this short review, transition-metal-catalyzed enantioselective synthesis of indoles from 2-alkynylanilines is summarized. 1 Introduction 2 Aminometalation triggered asymmetric cross-coupling reaction/insertion 2.1 Asymmetric Cross-Coupling Reaction 2.2 Asymmetric insertion of C=O, C=C and C≡N bonds 3 Asymmetric relay catalysis 4 Conclusion

Pd-catalyzed desulfitative arylation of olefins by N-methoxysulfonamide

A novel Pd-catalyzed protocol desulfitative Heck type reaction of N-methoxy aryl sulfonamides with alkenes was reported. The cross-coupling reaction was performed successfully with a variety of olefins to obtainaryl alkenes....

Synthesis of unprotected glyco-alkynones via molybdenum-catalyzed carbonylative Sonogashira cross-coupling reaction

Thermal ellipsoid representation of compound 3a.

An investigation of palladium-catalyzed Stille-type cross-coupling of nitroarenes in perylenediimide series

We report herein an unprecedented palladium-catalyzed cross-coupling reaction between mononitro-perylenediimide (PDI) and various arylstannanes. Optimized conditions developed with this Stille-type reaction allow the grafting of (hetero)aryls of various electronic nature...

Ni(ǁ)-catalyzed Reductive Cross-coupling Reaction of Oxalates and Thiosulfonates/Selenosulfonates

A Ni(ǁ)-catalyzed reductive cross-coupling reaction of oxalates and thiosulfonates/selenosulfonates to synthesize benzylic sulfides/selenides under mild conditions is developed. The oxalates prepared from the corresponding alcohols are used as carbon radical...

Fully π-conjugated, diyne-linked covalent organic frameworks formed via alkyne-alkyne cross-coupling reaction

A novel diyne-linked porphyrin-based COF was constructed through palladium catalyzed alkyne-alkyne coupling for the first time. The new material features inherent porosity, moderate crystallinity, excellent durability, full π-conjugation, and can...

Effects of the halogenido ligands on the Kumada-coupling catalytic activity of [Ni{tBuN(PPh2)2-κ2P}X2], X = Cl, Br, I, complexes

Novel nickel(ii) complexes [Ni(P,P)X2] = [Ni{tBuN(PPh2)2-κ2P}X2], X = Cl, Br, I, are prepared, characterized by IR and NMR spectroscopy, mass spectrometry and X-ray crystallography, and tested as catalysts in the Kumada cross-coupling reaction.