scholarly journals Design and synthesis of new azetidine-steroid derivative with inotropic activity in a heart failure model

2020 ◽  
Vol 58 (1) ◽  
pp. 10-19 ◽  
Author(s):  
Figueroa-Valverde Lauro ◽  
Lopez-Ramos Maria ◽  
Diaz-Cedillo Francisco ◽  
Rosas-Nexticapa Marcela ◽  
Mateu-Armand Virginia ◽  
...  
Keyword(s):  
Heart Failure ◽  
Failure Model ◽  
Design And Synthesis ◽  
Inotropic Activity ◽  
Heart Failure Model ◽  
Steroid Derivative

scholarly journals Synthesis of new azaindeno-acetonitrile derivative with inotropic activity against heart failure model

2019 ◽  
Vol 9 (6) ◽  
pp. 4598-4604
Keyword(s):  
Heart Failure ◽  
Biological Activity ◽  
Left Ventricular Pressure ◽  
Left Ventricular ◽  
Ventricular Pressure ◽  
Failure Model ◽  
Inotropic Activity ◽  
Inotropic Drugs ◽  
Heart Failure Model ◽  
Steroid Derivative

Several steroid derivatives have prepared as inotropic drugs; however, there are few reports on azaindeno-steroid derivatives with inotropic activity. The objective of this investigation was to prepare some azaindeno-acetonitrile derivatives (compounds 3 to 7) to evaluate their biological activity on left ventricular pressure. The first step was achieved by preparation of azaindeno-steroid derivatives using reactions of etherification and addition. The second stage involves the evaluation of biological activity from azaindeno-steroid derivatives on left ventricular pressure in a heart failure model using either estrone or an enone-steroid derivative (compound 2) as controls. The results showed that only compound 6 increases left ventricular pressure compared with estrone, compounds 2-5 and 6. In conclusion, the positive inotropic effect exerted by compound 6 depends on the functional groups involved in its chemical structure.

THE EFFECTS OF STRESS ON CARDIAC MECHANICAL DYSSYNCHRONY IN A HEART FAILURE MODEL

2014 ◽  
Vol 30 (10) ◽  
pp. S126
Author(s):  
S. Salimian ◽  
B. Thibault ◽  
V. Finnerty ◽  
J. Grégoire ◽  
F. Harel
Keyword(s):  
Heart Failure ◽  
Mechanical Dyssynchrony ◽  
Failure Model ◽  
Effects Of Stress ◽  
Heart Failure Model

scholarly journals Effects of captopril on the beta-adrenergic system in noninfarcted myocardium in the rat heart failure model

1991 ◽  
Vol 17 (2) ◽  
pp. A133 ◽  
Author(s):  
Karil Bellah ◽  
Thomas Raya ◽  
Sheldon Litwin ◽  
Steven Goldman ◽  
Joel Karliner
Keyword(s):  
Heart Failure ◽  
Rat Heart ◽  
Adrenergic System ◽  
Failure Model ◽  
Beta Adrenergic ◽  
Heart Failure Model

Echocardiography Evaluation of a Novel Stable Ovine Heart Failure Model Suitable for Cardiovascular Device Testing

2011 ◽  
Author(s):  
Peter W. Walsh ◽  
Craig S. McLachlan ◽  
Leigh Ladd ◽  
Arie Blitz ◽  
R. Mark Gillies ◽  
...  
Keyword(s):  
Heart Failure ◽  
Animal Models ◽  
Large Animal ◽  
Failure Model ◽  
Large Animal Models ◽  
Surgical Model ◽  
Coronary Ligation ◽  
Rapid Ventricular Pacing ◽  
Heart Failure Model ◽  
Underlying Pathology

Numerous large animal models of chronic cardiac ischemia have been developed to explore either pathological mechanisms and or device interventions in developed heart failure models. Traditionally chronic heart failure in large animal models such as sheep or pigs has been induced by either coronary ligation with or without reperfusion. Coronary ligation is often attempted in the open chest surgical model or more recently in the closed chest animal via angiography [1]. Both techniques can be challenging and also induce high mortality with the risk of myocardial stunning and resultant shock and or lethal arrhythmias. There is also difficulty in developing stable heart failure across cases where infarct sizes can be variable. One strategy to over come this variability has been via rapid ventricular pacing, however inducing heart failure does not induce sustained heart failure in many cases if the pacing is switched off, and additionally pacing does not induce some of the underlying pathology seen in the development of heart failure [1].

Seattle Heart Failure Model Scores Significantly Predict Medical Resource Use and Costs in HF-ACTION

2011 ◽  
Vol 17 (8) ◽  
pp. S80 ◽  
Author(s):  
Shelby D. Reed ◽  
Yanhong Li ◽  
Stephen J. Ellis ◽  
David J. Whellan ◽  
Kevin A. Schulman ◽  
...  
Keyword(s):  
Heart Failure ◽  
Resource Use ◽  
Failure Model ◽  
Medical Resource ◽  
Heart Failure Model
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