Identification of Three Separate Binding Sites on SHK Toxin, a Potent Inhibitor of Voltage-Dependent Potassium Channels in Human T-Lymphocytes and Rat Brain

1996 ◽  
Vol 219 (3) ◽  
pp. 696-701 ◽  
Author(s):  
M.W. Pennington ◽  
V.M. Mahnir ◽  
D.S. Krafte ◽  
I. Zaydenberg ◽  
M.E. Byrnes ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Potassium Channels ◽  
Rat Brain ◽  
Binding Sites ◽  
Potent Inhibitor ◽  
Toxin A ◽  
Human T Lymphocytes ◽  
Voltage Dependent

Volume regulation of murine T lymphocytes relies on voltage-dependent and two-pore domain potassium channels

2011 ◽  
Vol 1808 (8) ◽  
pp. 2036-2044 ◽  
Author(s):  
Nicole Bobak ◽  
Stefan Bittner ◽  
Joseph Andronic ◽  
Susanne Hartmann ◽  
Friederike Mühlpfordt ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Potassium Channels ◽  
Volume Regulation ◽  
Voltage Dependent ◽  
Pore Domain

scholarly journals Identification of two-pore domain potassium channels as potent modulators of osmotic volume regulation in human T lymphocytes

2013 ◽  
Vol 1828 (2) ◽  
pp. 699-707 ◽  
Author(s):  
Joseph Andronic ◽  
Nicole Bobak ◽  
Stefan Bittner ◽  
Petra Ehling ◽  
Christoph Kleinschnitz ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Potassium Channels ◽  
Volume Regulation ◽  
Human T Lymphocytes ◽  
Pore Domain

Structure, Function, and Chemical Synthesis of Vaejovis mexicanus Peptide 24: A Novel Potent Blocker of Kv1.3 Potassium Channels of Human T Lymphocytes

Biochemistry ◽  
2012 ◽  
Vol 51 (19) ◽  
pp. 4049-4061 ◽  
Author(s):  
Georgina B. Gurrola ◽  
Rogelio A. Hernández-López ◽  
Ricardo C. Rodríguez de la Vega ◽  
Zoltan Varga ◽  
Cesar V. F. Batista ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Potassium Channels ◽  
Chemical Synthesis ◽  
Structure Function ◽  
Human T Lymphocytes

Propofol blocks voltage-gated potassium channels in human T lymphocytes

1996 ◽  
Vol 52 (6) ◽  
pp. 843-849 ◽  
Author(s):  
Jerzy W. Mozrzymas ◽  
Andrzej Teisseyre ◽  
Franco Vittur
Keyword(s):  
T Lymphocytes ◽  
Potassium Channels ◽  
Voltage Gated ◽  
Human T Lymphocytes

scholarly journals Effect of Malnutrition on K+ Current in T Lymphocytes

2005 ◽  
Vol 12 (7) ◽  
pp. 808-813 ◽  
Author(s):  
Rafael Godínez Fernández ◽  
Joaquín Azpiroz Leehan ◽  
Reyna Fierro Pastrana ◽  
Rocío Ortíz Muñiz
Keyword(s):  
Membrane Potential ◽  
T Lymphocytes ◽  
Animal Models ◽  
Potassium Channels ◽  
Infectious Diseases ◽  
Severe Malnutrition ◽  
Voltage Dependent ◽  
K Current

ABSTRACT Severe malnutrition in children is frequently associated with infectious diseases. Animal models have been useful for studying the effects of malnutrition. One of the immunosuppressive mechanisms of malnutrition is inhibition of the activation of T lymphocytes. The voltage-dependent K(V) potassium channels are vital for the activation of T lymphocytes. The blockade of K(V) channels inhibits the activation of T lymphocytes. Malnutrition could affect the suitable synthesis of K(V) channels in T lymphocytes, producing changes in the magnitude and/or dependency of the voltage of the K+ current. We reported a significant decrease in the K+ current and activation to a 20 mV more positive membrane potential in T lymphocytes of rats with severe malnutrition. These results indicate that the diminution in the K+ conductance by alteration of K(V) channels in severe malnutrition is one of the mechanisms that inhibit the activation of T lymphocytes.

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