Oral Testosterone Self-Administration in Male Hamsters: Dose-Response, Voluntary Exercise, and Individual Differences

2002 ◽  
Vol 41 (3) ◽  
pp. 247-258 ◽  
Author(s):  
Ruth I. Wood
Keyword(s):  
Individual Differences ◽  
Dose Response ◽  
Voluntary Exercise ◽  
Self Administration

Differential temporal response patterns in rat cocaine self-administration studies: The cumulative record dose-response function

2020 ◽  
Vol 105 ◽  
pp. 106715
Author(s):  
Zachary J. Zimmermann ◽  
David V. Gauvin ◽  
Joshua D. Yoder ◽  
Jill A. Dalton ◽  
Theodore J. Baird ◽  
...  
Keyword(s):  
Response Function ◽  
Dose Response ◽  
Cumulative Record ◽  
Response Patterns ◽  
Temporal Response ◽  
Self Administration ◽  
Dose Response Function

Strain differences in the dose–response relationship for morphine self-administration and impulsive choice between Lewis and Fischer 344 rats

2010 ◽  
Vol 25 (6) ◽  
pp. 783-791 ◽  
Author(s):  
Carmen García-Lecumberri ◽  
Isabel Torres ◽  
Sonsoles Martín ◽  
José A Crespo ◽  
Miguel Miguéns ◽  
...  
Keyword(s):  
Dose Response ◽  
Strain Differences ◽  
Impulsive Choice ◽  
Fischer 344 Rats ◽  
Response Relationship ◽  
Self Administration ◽  
Dose Response Relationship ◽  
Fischer 344

scholarly journals Effects of adolescent caffeine consumption on cocaine self-administration and reinstatement of cocaine seeking

2018 ◽  
Vol 33 (1) ◽  
pp. 132-144
Author(s):  
Tracey A Larson ◽  
Casey E O’Neill ◽  
Michaela P Palumbo ◽  
Ryan K Bachtell
Keyword(s):  
Dose Response ◽  
Extinction Training ◽  
Schedules Of Reinforcement ◽  
Sprague Dawley ◽  
Self Administration ◽  
Caffeine Consumption ◽  
Adult Rats ◽  
Sprague Dawley Rats ◽  
Cocaine Seeking ◽  
Administration Procedure

Background: Caffeine consumption by children and adolescents has risen dramatically in recent years, yet the lasting effects of caffeine consumption during adolescence remain poorly understood. Aim: These experiments explore the effects of adolescent caffeine consumption on cocaine self-administration and seeking using a rodent model. Methods: Sprague-Dawley rats consumed caffeine for 28 days during the adolescent period. Following the caffeine consumption period, the caffeine solution was replaced with water for the remainder of the experiment. Age-matched control rats received water for the duration of the study. Behavioral testing in a cocaine self-administration procedure occurred during adulthood (postnatal days 62–82) to evaluate how adolescent caffeine exposure influenced the reinforcing properties of cocaine. Cocaine seeking was also tested during extinction training and reinstatement tests following cocaine self-administration. Results: Adolescent caffeine consumption increased the acquisition of cocaine self-administration and increased performance on different schedules of reinforcement. Consumption of caffeine in adult rats did not produce similar enhancements in cocaine self-administration. Adolescent caffeine consumption also produced an upward shift in the U-shaped dose response curve on cocaine self-administration maintained on a within-session dose-response procedure. Adolescent caffeine consumption had no effect on cocaine seeking during extinction training or reinstatement of cocaine seeking by cues or cocaine. Conclusions: These findings suggest that caffeine consumption during adolescence may enhance the reinforcing properties of cocaine, leading to enhanced acquisition that may contribute to increased addiction vulnerability.

Tolerance to self-administration of cocaine in rats: time course and dose-response determination using a multi-dose method

1993 ◽  
Vol 32 (3) ◽  
pp. 247-256 ◽  
Author(s):  
M.W. Emmett-Oglesby ◽  
R.L. Peltier ◽  
R.Y. Depoortere ◽  
C.L. Pickering ◽  
M.L. Hooper ◽  
...  
Keyword(s):  
Dose Response ◽  
Time Course ◽  
Self Administration ◽  
Dose Method ◽  
Response Determination

Neuroadaptive changes in mesocorticolimbic dopamine and acetylcholine neurons following cocaine or saline self-administration are dependent on pre-existing individual differences

Neuroscience ◽  
2003 ◽  
Vol 121 (4) ◽  
pp. 829-836 ◽  
Author(s):  
J.R Homberg ◽  
G Wardeh ◽  
H.S Raasø ◽  
A.N.M Schoffelmeer ◽  
T.J De Vries
Keyword(s):  
Individual Differences ◽  
Self Administration ◽  
Neuroadaptive Changes

scholarly journals Vertical Shifts in Self-Administration Dose–Response Functions Predict a Drug-Vulnerable Phenotype Predisposed to Addiction

2000 ◽  
Vol 20 (11) ◽  
pp. 4226-4232 ◽  
Author(s):  
Pier Vincenzo Piazza ◽  
Véronique Deroche-Gamonent ◽  
Françoise Rouge-Pont ◽  
Michel Le Moal
Keyword(s):  
Dose Response ◽  
Response Functions ◽  
Self Administration

Effect of systemically administered oxytocin on dose response for methylphenidate self‐administration and mesolimbic dopamine levels

2019 ◽  
Vol 1455 (1) ◽  
pp. 173-184 ◽  
Author(s):  
Mary R. Lee ◽  
Matthew C.H. Rohn ◽  
Claudio Zanettini ◽  
Mark A. Coggiano ◽  
Lorenzo Leggio ◽  
...  
Keyword(s):  
Dose Response ◽  
Mesolimbic Dopamine ◽  
Self Administration

Caffeine self-administration and withdrawal: incidence, individual differences and interrelationships

1993 ◽  
Vol 32 (3) ◽  
pp. 239-246 ◽  
Author(s):  
John R. Hughes ◽  
Alison H. Oliveto ◽  
Warren K. Bickel ◽  
Stephen T. Higgins ◽  
Gary J. Badger
Keyword(s):  
Individual Differences ◽  
Self Administration
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