Biochemical Phenotype and Its Relationship with Genotype in Hyperphenylalaninemia Heterozygotes

1999 ◽  
Vol 67 (2) ◽  
pp. 156-161 ◽  
Author(s):  
Judith Mallolas ◽  
Montserrat Milà ◽  
Nilo Lambruschini ◽  
Francisco José Cambra ◽  
Jaume Campistol ◽  
...  
Keyword(s):  
Biochemical Phenotype

Darwin’s molecule

Hemoglobin ◽  
2018 ◽  
pp. 201-232
Author(s):  
Jay F. Storz
Keyword(s):  
Protein Function ◽  
Evolutionary Biology ◽  
Lessons Learned ◽  
Atomic Resolution ◽  
Molecular Adaptation ◽  
Genetic Adaptation ◽  
Biochemical Phenotype ◽  
Causal Connections ◽  
Model Molecule ◽  
Model Protein

Chapter 9 discusses conceptual issues in protein evolution and provides a synthesis of lessons learned from studies of hemoglobin function. Using hemoglobin as a model molecule, we can exploit an unparalleled base of knowledge about structure-function relationships and we can characterize biophysical mechanisms of molecular adaptation at atomic resolution. It is therefore possible to document causal connections between genotype and biochemical phenotype at an unsurpassed level of rigor and detail. Moreover, since the oxygenation properties of hemoglobin provide a direct link between ambient O2 availability and aerobic metabolism, genetically based changes in protein function can be related to ecologically relevant aspects of organismal physiology. We therefore have a solid theoretical framework for making predictions and for interpreting observed associations between biochemical phenotype and fitness-related measures of whole-animal physiological performance. The chapter explores case studies that illustrate how experimental research on functional properties of a well-chosen model protein can be used to address some of the most conceptually expansive questions in evolutionary biology: Is genetic adaptation predictable? Why does evolution follow some pathways rather than others?

scholarly journals Biochemical fingerprinting of Vibrio parahaemolyticus by the PhenePlate system: comparison between pandemic and non-pandemic serotypes

2006 ◽  
Vol 134 (5) ◽  
pp. 985-989 ◽  
Author(s):  
MOKHLASUR RAHMAN ◽  
N. A. BHUIYAN ◽  
I. KUHN ◽  
T. RAMAMURTHY ◽  
M. RAHMAN ◽  
...  
Keyword(s):  
Vibrio Parahaemolyticus ◽  
Screening Method ◽  
Biochemical Phenotype ◽  
Biochemical Fingerprinting ◽  
High Level

During recent years a pandemic clone of Vibrio parahaemolyticus has emerged. Isolates of this clone are distributed among several serotypes, but are genotypically related. In the present study, a phenotyping method (biochemical fingerprinting) was used to characterize pandemic and non-pandemic isolates belonging to V. parahaemolyticus. It was found that the pandemic isolates showed a high level of phenotypic homogeneity and a majority of the pandemic isolates belonged to the same biochemical phenotype, whereas non-pandemic V. parahemolyticus isolates were more heterogeneous. In conclusion, biochemical fingerprinting of V. parahaemolyticus can be used as a first screening method to differentiate between pandemic and non-pandemic isolates of V. parahaemolyticus.

Can biochemical phenotype, obtained from herbarium samples, help taxonomic decisions? – A case study using Gentianaceae

Taxon ◽  
2019 ◽  
Vol 68 (4) ◽  
pp. 771-782 ◽  
Author(s):  
Adlin Afzan ◽  
Lise Bréant ◽  
Dirk U. Bellstedt ◽  
Jason R. Grant ◽  
Emerson F. Queiroz ◽  
...  
Keyword(s):  
Biochemical Phenotype

Biochemical phenotype and its relationship to treatment in 16 individuals with PCCB c.1606A > G (p.Asn536Asp) variant propionic acidemia

2020 ◽  
Vol 131 (3) ◽  
pp. 316-324
Author(s):  
Olivia Wenger ◽  
Miraides Brown ◽  
Brandon Smith ◽  
Devyani Chowdhury ◽  
Andrew H. Crosby ◽  
...  
Keyword(s):  
Propionic Acidemia ◽  
Biochemical Phenotype

scholarly journals Precursor-to-product ratios reflect biochemical phenotype in congenital adrenal hyperplasia

Metabolomics ◽  
2013 ◽  
Vol 10 (1) ◽  
pp. 123-131 ◽  
Author(s):  
Rebecca A. Hicks ◽  
Jennifer K. Yee ◽  
Catherine S. Mao ◽  
Steve Graham ◽  
Martin Kharrazi ◽  
...  
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Adrenal Hyperplasia ◽  
Biochemical Phenotype

scholarly journals A case report of ‘variant’ biochemical phenotype of Niemann-Pick C disease and a discussion of therapeutic options

2013 ◽  
Vol 47 (1) ◽  
pp. 86-89 ◽  
Author(s):  
Zygmunt Jamrozik ◽  
Piotr Szczudlik ◽  
Agnieszka Ługowska ◽  
Stefan Weiß ◽  
Arndt Rolfs ◽  
...  
Keyword(s):  
Case Report ◽  
Therapeutic Options ◽  
Biochemical Phenotype ◽  
Niemann Pick

scholarly journals O-112 The Indicators In The Biochemical Phenotype Of 58 Infants With Hepatorenal Tyrosinemia

2014 ◽  
Vol 99 (Suppl 2) ◽  
pp. A67.3-A68
Author(s):  
L Yargui ◽  
Z Sadi Mahammed ◽  
A Kemache ◽  
T Mahdi ◽  
M Djeddou ◽  
...  
Keyword(s):  
Biochemical Phenotype
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