An Internal Polypyrimidine-Tract-Binding Protein-Binding Site in the Hepatitis C Virus RNA Attenuates Translation, Which Is Relieved by the 3′-Untranslated Sequence

Takayoshi Ito; Michael M.C. Lai

doi:10.1006/viro.1998.9541

An Internal Polypyrimidine-Tract-Binding Protein-Binding Site in the Hepatitis C Virus RNA Attenuates Translation, Which Is Relieved by the 3′-Untranslated Sequence

Virology ◽

10.1006/viro.1998.9541 ◽

1999 ◽

Vol 254 (2) ◽

pp. 288-296 ◽

Cited By ~ 82

Author(s):

Takayoshi Ito ◽

Michael M.C. Lai

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Protein Binding ◽

Binding Site ◽

Protein Binding Site ◽

Polypyrimidine Tract ◽

Hepatitis C Virus Rna ◽

Untranslated Sequence ◽

Polypyrimidine Tract Binding Protein ◽

Virus Rna

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Interaction of polypyrimidine tract-binding protein with the 5' noncoding region of the hepatitis C virus RNA genome and its functional requirement in internal initiation of translation.

Journal of Virology ◽

10.1128/jvi.69.10.6367-6375.1995 ◽

1995 ◽

Vol 69 (10) ◽

pp. 6367-6375 ◽

Cited By ~ 141

Author(s):

N Ali ◽

A Siddiqui

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Functional Requirement ◽

Polypyrimidine Tract ◽

Hepatitis C Virus Rna ◽

Polypyrimidine Tract Binding ◽

Polypyrimidine Tract Binding Protein ◽

Virus Rna ◽

Initiation Of Translation ◽

Internal Initiation

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Determination of the secondary structure of and cellular protein binding to the 3'-untranslated region of the hepatitis C virus RNA genome.

Journal of Virology ◽

10.1128/jvi.71.11.8698-8706.1997 ◽

1997 ◽

Vol 71 (11) ◽

pp. 8698-8706 ◽

Cited By ~ 120

Author(s):

T Ito ◽

M M Lai

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Secondary Structure ◽

Protein Binding ◽

Untranslated Region ◽

Cellular Protein ◽

Hepatitis C Virus Rna ◽

Virus Rna ◽

Rna Genome

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Faculty Opinions recommendation of Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1119118.575267 ◽

2008 ◽

Author(s):

Lynne Maquat ◽

Olaf Isken

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Binding Site ◽

Hepatitis C Virus Rna ◽

Dependent Function ◽

Virus Rna ◽

Rna Genome

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Roles of the polypyrimidine tract and 3′ noncoding region of hepatitis C virus RNA in the internal ribosome entry site-mediated translation

Archives of Virology ◽

10.1007/s00705-005-0491-3 ◽

2005 ◽

Vol 150 (6) ◽

pp. 1085-1099 ◽

Cited By ~ 8

Author(s):

H. Wang ◽

X. T. Shen ◽

R. Ye ◽

S. Y. Lan ◽

L. Xiang ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Internal Ribosome Entry Site ◽

Noncoding Region ◽

Polypyrimidine Tract ◽

Hepatitis C Virus Rna ◽

Entry Site ◽

Internal Ribosome Entry ◽

Virus Rna

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La Protein Binding at the GCAC Site Near the Initiator AUG Facilitates the Ribosomal Assembly on the Hepatitis C Virus RNA to Influence Internal Ribosome Entry Site-mediated Translation

Journal of Biological Chemistry ◽

10.1074/jbc.m403417200 ◽

2004 ◽

Vol 279 (29) ◽

pp. 29879-29888 ◽

Cited By ~ 41

Author(s):

Renuka Pudi ◽

Prabhavathi Srinivasan ◽

Saumitra Das

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Protein Binding ◽

Internal Ribosome Entry Site ◽

Hepatitis C Virus Rna ◽

Entry Site ◽

Internal Ribosome Entry ◽

Ribosomal Assembly ◽

La Protein ◽

Virus Rna

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Position-Dependent Function for a Tandem MicroRNA miR-122-Binding Site Located in the Hepatitis C Virus RNA Genome

Cell Host & Microbe ◽

10.1016/j.chom.2008.05.013 ◽

2008 ◽

Vol 4 (1) ◽

pp. 77-85 ◽

Cited By ~ 295

Author(s):

Catherine L. Jopling ◽

Sylvia Schütz ◽

Peter Sarnow

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Binding Site ◽

Hepatitis C Virus Rna ◽

Dependent Function ◽

Virus Rna ◽

Rna Genome

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Peginterferon-Alfa2a Plus Ribavirin for 48 Versus 72 Weeks in Patients With Detectable Hepatitis C Virus RNA at Week 4 of Treatment

Yearbook of Gastroenterology ◽

10.1016/s0739-5930(08)70204-6 ◽

2007 ◽

Vol 2007 ◽

pp. 256

Author(s):

G.A. Makar

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Hepatitis C Virus Rna ◽

Virus Rna

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Faculty Opinions recommendation of Adaptive mutations producing efficient replication of genotype 1a hepatitis C virus RNA in normal Huh7 cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1020977.239586 ◽

2004 ◽

Author(s):

Jeffrey Cohen

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Hepatitis C Virus Rna ◽

Adaptive Mutations ◽

Genotype 1A ◽

Virus Rna ◽

Huh7 Cells ◽

Efficient Replication

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Faculty Opinions recommendation of Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1026499.325208 ◽

2005 ◽

Author(s):

Ken Wilson

Keyword(s):

Fatty Acids ◽

Hepatitis C Virus ◽

Hepatitis C ◽

Rna Replication ◽

Hepatitis C Virus Rna ◽

Virus Rna

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Faculty Opinions recommendation of Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1028030.335935 ◽

2005 ◽

Author(s):

Richard Kuhn

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Hepatitis C Virus Rna ◽

Virus Rna

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