La Protein Binding at the GCAC Site Near the Initiator AUG Facilitates the Ribosomal Assembly on the Hepatitis C Virus RNA to Influence Internal Ribosome Entry Site-mediated Translation

Journal of Biological Chemistry ◽

10.1074/jbc.m403417200 ◽

2004 ◽

Vol 279 (29) ◽

pp. 29879-29888 ◽

Author(s):

Renuka Pudi ◽

Prabhavathi Srinivasan ◽

Saumitra Das

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Protein Binding ◽

Internal Ribosome Entry Site ◽

Hepatitis C Virus Rna ◽

Internal Ribosome Entry ◽

Ribosomal Assembly ◽

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Frequency of nucleotide sequence variations in the internal ribosome entry site region of hepatitis C virus RNA isolated from responding and non-responding patients with hepatitis C virus genotype 3 infection

VirusDisease ◽

10.1007/s13337-016-0335-7 ◽

2016 ◽

Vol 27 (3) ◽

pp. 251-259 ◽

Author(s):

Anzar Ashraf ◽

Anita Chakravarti ◽

Priyamvada Roy ◽

Premashish Kar ◽

Oves Siddiqui

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Internal Ribosome Entry Site ◽

Hepatitis C Virus Rna ◽

Virus Genotype ◽

Internal Ribosome Entry ◽

Virus Rna ◽

Sequence Variations

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The La antigen binds 5' noncoding region of the hepatitis C virus RNA in the context of the initiator AUG codon and stimulates internal ribosome entry site-mediated translation

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.94.6.2249 ◽

1997 ◽

Vol 94 (6) ◽

pp. 2249-2254 ◽

Author(s):

N. Ali ◽

A. Siddiqui

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Internal Ribosome Entry Site ◽

Noncoding Region ◽

Hepatitis C Virus Rna ◽

Internal Ribosome Entry ◽

Virus Rna ◽

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Internal ribosome entry site within hepatitis C virus RNA.

Journal of Virology ◽

10.1128/jvi.66.3.1476-1483.1992 ◽

1992 ◽

Vol 66 (3) ◽

pp. 1476-1483 ◽

Author(s):

K Tsukiyama-Kohara ◽

N Iizuka ◽

M Kohara ◽

A Nomoto

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Internal Ribosome Entry Site ◽

Hepatitis C Virus Rna ◽

Internal Ribosome Entry ◽

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Roles of the polypyrimidine tract and 3′ noncoding region of hepatitis C virus RNA in the internal ribosome entry site-mediated translation

Archives of Virology ◽

10.1007/s00705-005-0491-3 ◽

2005 ◽

Vol 150 (6) ◽

pp. 1085-1099 ◽

Author(s):

H. Wang ◽

X. T. Shen ◽

R. Ye ◽

S. Y. Lan ◽

L. Xiang ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Internal Ribosome Entry Site ◽

Noncoding Region ◽

Polypyrimidine Tract ◽

Hepatitis C Virus Rna ◽

Internal Ribosome Entry ◽

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The sequence element of the internal ribosome entry site and a 25-kilodalton cellular protein contribute to efficient internal initiation of translation of hepatitis C virus RNA.

Journal of Virology ◽

10.1128/jvi.71.2.1662-1666.1997 ◽

1997 ◽

Vol 71 (2) ◽

pp. 1662-1666 ◽

Author(s):

S Fukushi ◽

C Kurihara ◽

N Ishiyama ◽

F B Hoshino ◽

A Oya ◽

...

Keyword(s):

Hepatitis C ◽

Internal Ribosome Entry Site ◽

Cellular Protein ◽

Hepatitis C Virus Rna ◽

Sequence Element ◽

Internal Ribosome Entry ◽

Virus Rna ◽

Initiation Of Translation ◽

Internal Initiation

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La Protein Required for Internal Ribosome Entry Site–Directed Translation Is a Potential Therapeutic Target for Hepatitis C Virus Replication

The Journal of Infectious Diseases ◽

10.1086/653081 ◽

2010 ◽

Vol 202 (1) ◽

pp. 75-85 ◽

Author(s):

Takayoshi Shirasaki ◽

Masao Honda ◽

Hideki Mizuno ◽

Tetsuro Shimakami ◽

Hikari Okada ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Replication ◽

Internal Ribosome Entry Site ◽

Therapeutic Target ◽

Potential Therapeutic Target ◽

Internal Ribosome Entry ◽

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A Modular Approach to Synthetic RNA Binders of the Hepatitis C Virus Internal Ribosome Entry Site

ChemBioChem ◽

10.1002/cbic.201000177 ◽

2010 ◽

Vol 11 (10) ◽

pp. 1364-1367 ◽

Author(s):

Maia Carnevali ◽

Jerod Parsons ◽

David L. Wyles ◽

Thomas Hermann

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Internal Ribosome Entry Site ◽

Modular Approach ◽

Internal Ribosome Entry ◽

Rna Binders ◽

Virus Internal Ribosome Entry

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An Internal Polypyrimidine-Tract-Binding Protein-Binding Site in the Hepatitis C Virus RNA Attenuates Translation, Which Is Relieved by the 3′-Untranslated Sequence

Virology ◽

10.1006/viro.1998.9541 ◽

1999 ◽

Vol 254 (2) ◽

pp. 288-296 ◽

Author(s):

Takayoshi Ito ◽

Michael M.C. Lai

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Protein Binding ◽

Binding Site ◽

Protein Binding Site ◽

Polypyrimidine Tract ◽

Hepatitis C Virus Rna ◽

Untranslated Sequence ◽

Polypyrimidine Tract Binding Protein ◽

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Nucleotide sequence variations in the internal ribosome entry site of hepatitis C virus-1b: No association with efficacy of interferon therapy or serum HCV-RNA levels

10.1002/hep.510260633 ◽

1997 ◽

Vol 26 (6) ◽

pp. 1616-1620 ◽

Author(s):

C Yamamoto ◽

N Enomoto ◽

M Kurosaki ◽

S Yu ◽

J Tazawa ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Nucleotide Sequence ◽

Internal Ribosome Entry Site ◽

Interferon Therapy ◽

Hcv Rna ◽

Internal Ribosome Entry ◽

Sequence Variations ◽

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Differential Effects on the Hepatitis C Virus (HCV) Internal Ribosome Entry Site by Vitamin B12 and the HCV Core Protein

Journal of Virology ◽

10.1128/jvi.78.21.12075-12081.2004 ◽

2004 ◽

Vol 78 (21) ◽

pp. 12075-12081 ◽

Author(s):

Dongsheng Li ◽

William B. Lott ◽

John Martyn ◽

Gholamreza Haqshenas ◽

Eric J. Gowans

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Internal Ribosome Entry Site ◽

Core Protein ◽

Vitamin B ◽

Internal Ribosome Entry ◽

Hcv Core Protein ◽

ABSTRACT To investigate the role of the hepatitis C virus internal ribosome entry site (HCV IRES) domain IV in translation initiation and regulation, two chimeric IRES elements were constructed to contain the reciprocal domain IV in the otherwise HCV and classical swine fever virus IRES elements. This permitted an examination of the role of domain IV in the control of HCV translation. A specific inhibitor of the HCV IRES, vitamin B12, was shown to inhibit translation directed by all IRES elements which contained domain IV from the HCV and the GB virus B IRES elements, whereas the HCV core protein could only suppress translation from the wild-type HCV IRES. Thus, the mechanisms of translation inhibition by vitamin B12 and the core protein differ, and they target different regions of the IRES.

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