The Role of Biomechanics in Functional Tissue Engineering for Articular Cartilage

2003 ◽  
pp. 37-60 ◽  
Author(s):  
X. Edward Guo ◽  
Helen H. Lu ◽  
Morakot Likhitpanichkul ◽  
Van C. Mow
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Functional Tissue Engineering ◽  
Functional Tissue

Functional Tissue Engineering in Articular Cartilage Repair: Is There a Role for Electromagnetic Biophysical Stimulation?

2013 ◽  
Vol 19 (4) ◽  
pp. 353-367 ◽  
Author(s):  
Milena Fini ◽  
Stefania Pagani ◽  
Gianluca Giavaresi ◽  
Monica De Mattei ◽  
Alessia Ongaro ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Cartilage Repair ◽  
Articular Cartilage Repair ◽  
Functional Tissue Engineering ◽  
Functional Tissue

A Paradigm for Functional Tissue Engineering of Articular Cartilage via Applied Physiologic Deformational Loading

2004 ◽  
Vol 32 (1) ◽  
pp. 35-49 ◽  
Author(s):  
Clark T. Hung ◽  
Robert L. Mauck ◽  
Christopher C.-B. Wang ◽  
Eric G. Lima ◽  
Gerard A. Ateshian
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Functional Tissue Engineering ◽  
Functional Tissue

Functional Tissue Engineering of Articular Cartilage With Adult Chondrocytes

2009 ◽  
Author(s):  
Liming Bian ◽  
Kenneth W. Ng ◽  
Eric G. Lima ◽  
Prakash S. Jayabalan ◽  
Aaron M. Stoker ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Animal Model ◽  
Articular Cartilage ◽  
Dynamic Deformation ◽  
Successful Outcome ◽  
Compressive Properties ◽  
Functional Tissue Engineering ◽  
Primary Chondrocytes ◽  
Functional Tissue ◽  
Proteoglycan Content

The concept of cartilage functional tissue engineering (FTE) has promoted the use of physiologic loading bioreactor systems to cultivate engineered tissues with load-bearing properties [1]. Prior studies have demonstrated that culturing agarose constructs seeded with primary bovine chondrocytes from immature joints, and subjected to dynamic deformation, produced equilibrium compressive properties and proteoglycan content matching the native tissue [2]. In the process of translating these results to an adult canine animal model, it was found that protocols previously successful with immature bovine primary chondrocytes did not produce the same successful outcome when using adult canine primary chondrocytes [3]. The objective of this study was to assess the efficacy of a modified FTE protocol using adult (canine) chondrocyte-seeded hydrogel constructs and applied dynamic loading.

Role of Biomechanics in Functional Tissue Engineering

2004 ◽  
Vol 844 ◽  
Author(s):  
Kai-Nan An
Keyword(s):  
Tissue Engineering ◽  
Strategic Information ◽  
Functional Tissue Engineering ◽  
Functional Tissue ◽  
Before And After ◽  
The Matrix ◽  
Design And Manufacture ◽  
Stimulation Of

ABSTRACTFunctional tissue engineering establishes functional criteria for design and manufacture of the scaffold matrix for repair and replacement. It also provides useful and strategic information in mechanical stimulation of the cells seeded in the matrix before and after surgical placement to enhance the success of tissue engineering. Biomechanics plays an important role in accomplishing these requirements by assessing the in vivo environment and the material properties.

A Paradigm for Functional Tissue Engineering

2000 ◽  
Author(s):  
David L. Butler
Keyword(s):  
Tissue Engineering ◽  
Tendon Repair ◽  
National Committee ◽  
New Paradigm ◽  
Functional Tissue Engineering ◽  
Functional Tissue ◽  
Tissue Engineer ◽  
Surgical Implants ◽  
The Us

Abstract Clinicians, biologists, and engineers face difficult challenges in engineering effective, cell-based composites for repair of orthopaedic and cardiovascular tissues. Whether repairing articular cartilage, bone, or blood vessel, the demands placed on the surgical implants can threaten the long-term success of the procedure. In 1998, the US National Committee on Biomechanics addressed this problem by suggesting a new paradigm for tissue engineering called “functional tissue engineering” or FTE. FTE seeks to address several important questions. What are the biomechanical demands placed upon the normal tissue and hence the tissue engineered implant after surgery? What parameters should a tissue engineer design into the implant before surgery? And what biomechanical parameters should the tissue engineer track to determine if the resulting repair is successful? To illustrate the principles, this presentation will discuss tendon repair as a model system for functional tissue engineering.

Functional Tissue Engineering Parameters toward Designing Repair and Replacement Strategies

2004 ◽  
Vol 427 ◽  
pp. S190-S199 ◽  
Author(s):  
David L Butler ◽  
Jason T Shearn ◽  
Natalia Juncosa ◽  
Matthew R Dressler ◽  
Shawn A Hunter
Keyword(s):  
Tissue Engineering ◽  
Functional Tissue Engineering ◽  
Functional Tissue ◽  
Engineering Parameters
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