Role of the Human Apurinic Endonuclease Ape1/ref-1 in Germ Cell Tumours

2002 ◽  
pp. 76-84
Author(s):  
M. R. Kelley ◽  
D. Wang ◽  
S-H. Jung ◽  
J. Shen ◽  
T. H. Albright ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumours

Pineal tumours

2019 ◽  
pp. 427-438
Author(s):  
Mueez Waqar ◽  
Samantha Mills ◽  
Conor L Mallucci ◽  
Michael D Jenkinson
Keyword(s):  
Germ Cell ◽  
Adjuvant Radiotherapy ◽  
Residual Disease ◽  
Germ Cell Tumour ◽  
Third Ventriculostomy ◽  
Germ Cell Tumours ◽  
Line Treatment ◽  
Surgical Biopsy ◽  
First Line Treatment

Tumours of the pineal are very rare, tend to be more common in children and while there are a wide variety of pathologies the majority are germ cell tumours and pineal parenchymal tumours. These tumours usually present with hydrocephalus and endoscopic third ventriculostomy is the operation of choice. It is important to test for tumour markers in the blood and cerebrospinal fluid, since the diagnosis of a secreting germ cell tumour precludes the need for surgery. Surgical biopsy can be performed by endoscopy or with frame-based stereotaxy. For germ cell tumours chemotherapy and radiotherapy are the mainstay of treatment, but surgery has a role in the management of residual disease. For primary parenchymal tumours, maximum surgical resection is the first-line treatment and can be curative for pineocytoma. Pineoblastoma require adjuvant radiotherapy and for intermediate grade pineal tumours the role of radiotherapy is still being evaluated.

The role of thoracotomy in managing postchemotherapy residual thoracic masses in patients with nonseminomatous germ cell tumours

2003 ◽  
Vol 91 (6) ◽  
pp. 469-473 ◽  
Author(s):  
M.S. McGuire ◽  
F. Rabbani ◽  
H. Mohseni ◽  
M. Bains ◽  
R. Motzer ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumours

The role of BLIMP1 and its putative downstream target TFAP2C in germ cell development and germ cell tumours

2011 ◽  
Vol 34 (4pt2) ◽  
pp. e152-e159 ◽  
Author(s):  
S. Schäfer ◽  
J. Anschlag ◽  
D. Nettersheim ◽  
N. Haas ◽  
L. Pawig ◽  
...  
Keyword(s):  
Germ Cell ◽  
Cell Development ◽  
Germ Cell Tumours ◽  
Germ Cell Development ◽  
Downstream Target
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