Trophoblast Cell Differentiation: Expression of the Placental Prolactin Family

1993 ◽  
pp. 45-67 ◽  
Author(s):  
Michael J. Soares ◽  
Teresa N. Faria ◽  
Gary P. Hamlin ◽  
Xing-Jian Lu ◽  
Santanu Deb
Keyword(s):  
Cell Differentiation ◽  
Trophoblast Cell

Intersection of regulatory pathways controlling hemostasis and hemochorial placentation

2021 ◽  
Vol 118 (50) ◽  
pp. e2111267118
Author(s):  
Masanaga Muto ◽  
Damayanti Chakraborty ◽  
Kaela M. Varberg ◽  
Ayelen Moreno-Irusta ◽  
Khursheed Iqbal ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Differentiation ◽  
Cell Invasion ◽  
Cell Development ◽  
Trophoblast Cell ◽  
Extravillous Trophoblast ◽  
Cell Phenotype ◽  
Trophoblast Cells ◽  
Rat Models ◽  
Endovascular Trophoblast

Hemochorial placentation is characterized by the development of trophoblast cells specialized to interact with the uterine vascular bed. We utilized trophoblast stem (TS) cell and mutant rat models to investigate regulatory mechanisms controlling trophoblast cell development. TS cell differentiation was characterized by acquisition of transcript signatures indicative of an endothelial cell-like phenotype, which was highlighted by the expression of anticoagulation factors including tissue factor pathway inhibitor (TFPI). TFPI localized to invasive endovascular trophoblast cells of the rat placentation site. Disruption of TFPI in rat TS cells interfered with development of the endothelial cell-like endovascular trophoblast cell phenotype. Similarly, TFPI was expressed in human invasive/extravillous trophoblast (EVT) cells situated within first-trimester human placental tissues and following differentiation of human TS cells. TFPI was required for human TS cell differentiation to EVT cells. We next investigated the physiological relevance of TFPI at the placentation site. Genome-edited global TFPI loss-of-function rat models revealed critical roles for TFPI in embryonic development, resulting in homogeneous midgestation lethality prohibiting analysis of the role of TFPI as a regulator of the late-gestation wave of intrauterine trophoblast cell invasion. In vivo trophoblast-specific TFPI knockdown was compatible with pregnancy but had profound effects at the uterine–placental interface, including restriction of the depth of intrauterine trophoblast cell invasion while leading to the accumulation of natural killer cells and increased fibrin deposition. Collectively, the experimentation implicates TFPI as a conserved regulator of invasive/EVT cell development, uterine spiral artery remodeling, and hemostasis at the maternal–fetal interface.

Progress in deciphering trophoblast cell differentiation during human placentation

2020 ◽  
Vol 67 ◽  
pp. 86-91
Author(s):  
Zhenyu Xiao ◽  
Long Yan ◽  
Xiaoyan Liang ◽  
Hongmei Wang
Keyword(s):  
Cell Differentiation ◽  
Trophoblast Cell

Rcho-1 Trophoblast Stem Cells: A Model System for Studying Trophoblast Cell Differentiation

2005 ◽  
pp. 157-176
Author(s):  
Namita Sahgal ◽  
Lindsey N. Canham ◽  
Brent Canham ◽  
Michael J. Soares
Keyword(s):  
Stem Cells ◽  
Cell Differentiation ◽  
Model System ◽  
Trophoblast Cell ◽  
Trophoblast Stem Cells ◽  
Trophoblast Stem

scholarly journals Phosphatidylinositol 3 kinase modulation of trophoblast cell differentiation

2010 ◽  
Vol 10 (1) ◽  
pp. 97 ◽  
Author(s):  
Lindsey N. Kent ◽  
Toshihiro Konno ◽  
Michael J. Soares
Keyword(s):  
Cell Differentiation ◽  
Trophoblast Cell ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphatidylinositol 3

Involvement of syncytin glycoprotein in human trophoblast cell differentiation and endocrine activity

2007 ◽  
Vol 115 (S 1) ◽  
Author(s):  
I Knerr ◽  
C Weigel ◽  
K Hermann ◽  
S Kausler ◽  
U Meißner ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Trophoblast Cell ◽  
Endocrine Activity ◽  
Human Trophoblast

Trophoblast cell differentiation and organization: Role of fetal and ovarian signals

Placenta ◽  
1993 ◽  
Vol 14 (5) ◽  
pp. 529-545 ◽  
Author(s):  
Katherine F. Roby ◽  
Michael J. Soares
Keyword(s):  
Cell Differentiation ◽  
Trophoblast Cell

Involvement of Sp-1 in the Regulation of the Id-1 Gene during Trophoblast Cell Differentiation

Placenta ◽  
2007 ◽  
Vol 28 (2-3) ◽  
pp. 192-198 ◽  
Author(s):  
T. Takeda ◽  
M. Sakata ◽  
A. Isobe ◽  
T. Yamamoto ◽  
F. Nishimoto ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Trophoblast Cell

Trophoblast cell differentiation: Acquisition of endocrine activities

Placenta ◽  
1996 ◽  
Vol 17 (5-6) ◽  
pp. A2
Author(s):  
Michael J. Soares ◽  
Belinda M. Chapman ◽  
Thomas J. Peters ◽  
Kyle E. Orwig ◽  
Takayuki Kamei ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Trophoblast Cell
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