Electrophysiological Aspects of Adenosine Receptor Function

1990 ◽  
pp. 143-172 ◽  
Author(s):  
Thomas V. Dunwiddie
Keyword(s):  
Adenosine Receptor ◽  
Receptor Function

Theophylline down-regulates adenosine receptor function

1990 ◽  
Vol 509 (1) ◽  
pp. 141-144 ◽  
Author(s):  
Judit Mally ◽  
J.H. Connick ◽  
T.W. Stone
Keyword(s):  
Adenosine Receptor ◽  
Receptor Function

scholarly journals A2A adenosine receptor function in patients with vasovagal syncope

EP Europace ◽  
2013 ◽  
Vol 15 (9) ◽  
pp. 1328-1332 ◽  
Author(s):  
F. Franceschi ◽  
Y. By ◽  
E. Peyrouse ◽  
J. Fromonot ◽  
V. Gerolami ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
Vasovagal Syncope ◽  
Receptor Function ◽  
A2a Adenosine Receptor

Genetic modulation of adenosine receptor function and adenosine handling in murine hearts: Insights and issues

2007 ◽  
Vol 42 (4) ◽  
pp. 693-705 ◽  
Author(s):  
Kevin J. Ashton ◽  
Jason N. Peart ◽  
R. Ray Morrison ◽  
G. Paul Matherne ◽  
Michael R. Blackburn ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
Receptor Function ◽  
Genetic Modulation

Regulation of Adenosine Receptor Function by Theophylline in Rat Aorta

1994 ◽  
Vol 24 (1) ◽  
pp. 95-99 ◽  
Author(s):  
Tahir Hussain ◽  
John H. Leigh ◽  
S. Jamal Mustafa
Keyword(s):  
Adenosine Receptor ◽  
Rat Aorta ◽  
Receptor Function

Effects of membrane polyunsaturated fatty acids on adenosine receptor function in intact N1E-115 neuroblastoma cells

1990 ◽  
Vol 68 (1) ◽  
pp. 392-395 ◽  
Author(s):  
M. G. Murphy ◽  
Z. Byczko
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Adenosine Receptor ◽  
Adenosine Receptors ◽  
Neuroblastoma Cells ◽  
Neural Cells ◽  
Camp Accumulation ◽  
Receptor Function ◽  
Membrane Phospholipids ◽  
Mean Values

We have examined the effects of increasing membrane polyunsaturated fatty acids (PUFAs) on adenosine receptor function in intact N1E-115 neuroblastoma cells. Addition of linoleic acid to the culture medium for 48 h resulted in an approximate threefold increase in the amount of ω6 fatty acids esterified to membrane phospholipids. Basal cAMP accumulation was significantly higher in the PUFA-enriched cells than in controls, although the differences could be diminished by approximately 75% by treatment of the cells with adenosine deaminase or 8-phenyltheophylline. Exposure of the cultures to the stable adenosine analogue 5′-N-ethylcarboxyamide adenosine (NECA) resulted in concentration-dependent increases in cAMP accumulation. Data from saturation experiments indicated that the maximum amount of cAMP that could be formed in response to NECA in the PUFA-enriched cells was twice that in control cells. Also, the amount of agonist required to elicit half maximal stimulation in the supplemented cells was significantly less than in the control cells (mean values for EC50, 0.85 and 1.43 μM, respectively). The results of this study demonstrate that membrane PUFA have the ability to modify interactions between adenosine receptors and adenylate cyclase in neural cells, a fact that is of potential importance in considering the central role that adenosine plays as a neuromodulator in the nervous system.Key words: polyunsaturated fatty acids, neuroblastoma cells, adenosine receptors, cAMP.

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