We describe q-deformation of the extended supersymmetry and construct q-extended supersymmetric Hamiltonian. For this purpose we formulate q-superspace formalism and construct q-supertransformation group. On this basis q-extended supersymmetric Lagrangian is built. The canonical quantization of this system is considered. The connection with multi-dimensional matrix representations of the parasupersymmetric quantum mechanics is discussed and q-extended supersymmetric harmonic oscillator is considered as a simplest example of the described constructions. We show that extended supersymmetric Hamiltonians obey not only extended SUSY but also the whole family of symmetries (q-extended supersymmetry) which is parametrized by continuous parameter q on the unit circle.