Dietary Boron Affects Bone Calcification in Magnesium and Cholecalciferol Deficient Chicks

1988 ◽  
pp. 275-276 ◽  
Author(s):  
Curtiss D. Hunt ◽  
Forrest H. Nielsen
Keyword(s):  
Dietary Boron ◽  
Bone Calcification

Bone calcification and calcium homeostasis in rats with non-insulin-dependent diabetes induced by streptozocin

Diabetes ◽  
1985 ◽  
Vol 34 (4) ◽  
pp. 365-372 ◽  
Author(s):  
J. Levy ◽  
S. L. Teitelbaum ◽  
J. R. Gavin ◽  
A. Fausto ◽  
H. Kurose ◽  
...  
Keyword(s):  
Calcium Homeostasis ◽  
Insulin Dependent Diabetes ◽  
Insulin Dependent ◽  
Bone Calcification

scholarly journals Effects of dietary boron in rats fed a vitamin D-deficient diet.

1994 ◽  
Vol 102 (suppl 7) ◽  
pp. 55-58 ◽  
Author(s):  
J N Dupre ◽  
M J Keenan ◽  
M Hegsted ◽  
A M Brudevold
Keyword(s):  
Vitamin D ◽  
Deficient Diet ◽  
Dietary Boron

Dietary boron intakes of selected populations in the United States

1998 ◽  
Vol 66 (1-3) ◽  
pp. 65-78 ◽  
Author(s):  
Susan L. Meacham ◽  
Curtiss D. Hunt
Keyword(s):  
United States ◽  
The United States ◽  
Dietary Boron

VKORC1 deficiency in mice causes early postnatal lethality due to severe bleeding

2009 ◽  
Vol 101 (06) ◽  
pp. 1044-1050 ◽  
Author(s):  
Gabriele Spohn ◽  
Andre Kleinridders ◽  
F. Thomas Wunderlich ◽  
Matthias Watzka ◽  
Frank Zaucke ◽  
...  
Keyword(s):  
Vitamin K ◽  
Knockout Mice ◽  
Severe Bleeding ◽  
Clotting Factors ◽  
Vitamin K Cycle ◽  
Severe Deficiency ◽  
Epoxide Reductase ◽  
Bone Calcification

SummaryVitamin K hydroquinone is oxidised to the epoxide form (K>O) during vitamin K-dependent posttranslational γ-glutamyl carboxylation resulting in biological active so called vitamin K-dependent proteins. In turn, K>O is reduced by the enzyme VKORC1 (vitamin K epoxide reductase complex component 1) to complete the vitamin K cycle. To investigate the biological role of VKORC1 in vivo, we generated VKORC1 knockout mice. Homozygous VKORC1-deficient mice developed normally until birth. Within 2–20 days after birth, the knockout mice died due to extensive, predominantly intracerebral haemorrhage. Bleeding resulted from a severe deficiency of γ-carboxylated clotting factors. This lethal phenotype could be rescued by oral administration of vitamin K. Additionally, morphometric analysis of the limbs in VKORC1-deficient animals revealed reduced length of bone calcification relative to wild-type control mice. The observed phenotype of VKORC1 knockout mice excludes the existence of other enzymes with VKOR activity that can substitute to supply vitamin K hydroquinone required for maturation of blood clotting factors. Thus, our study underscores the essential role of VKORC1 in vitamin K-dependent γ-glutamyl carboxylation.

Effect of Dietary Boron on Bone Characteristics and Plasma Parameters in Young Pigs

2002 ◽  
pp. 1067-1069
Author(s):  
T. A. Armstrong ◽  
J. W. Spears ◽  
T. E. Engle ◽  
C. L. Wright
Keyword(s):  
Plasma Parameters ◽  
Young Pigs ◽  
Dietary Boron

The Effect of Dietary Fat on Bone Calcification in the Growing Rat

1943 ◽  
Vol 25 (5) ◽  
pp. 479-489 ◽  
Author(s):  
Rudolf Bunkfeldt ◽  
Harry Steenbock
Keyword(s):  
Dietary Fat ◽  
Growing Rat ◽  
Bone Calcification
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