Biological Trace Element Research
Latest Publications


TOTAL DOCUMENTS

8352
(FIVE YEARS 2141)

H-INDEX

77
(FIVE YEARS 22)

Published By Springer-Verlag

1559-0720, 0163-4984

Author(s):  
Jerome Ndudi Asiwe ◽  
Tarela Melish Elias Daubry ◽  
Idara Asuquo Okon ◽  
Ajirioghene Emamuzou Akpotu ◽  
Ebunoluwa Oluwabusola Adagbada ◽  
...  
Keyword(s):  

Author(s):  
Heba Bassiony ◽  
Akmal A. El-Ghor ◽  
Taher A. Salaheldin ◽  
Salwa Sabet ◽  
Mona M. Mohamed

AbstractNanoparticles can potentially cause adverse effects on cellular and molecular level. The present study aimed to investigate the histopathological changes and DNA damage effects of magnetite nanoparticles (MNPs) on female albino mice model with Ehrlich solid carcinoma (ESC). Magnetite nanoparticles coated with L-ascorbic acid (size ~ 25.0 nm) were synthesized and characterized. Mice were treated with MNPs day by day, intraperitoneally (IP), intramuscularly (IM), or intratumorally (IT). Autopsy samples were taken from the solid tumor, thigh muscle, liver, kidney, lung, spleen, and brain for assessment of iron content, histopathological examination, and genotoxicity using comet assay. The liver, spleen, lung, and heart had significantly higher iron content in groups treated IP. On the other hand, tumor, muscles, and the liver had significantly higher iron content in groups treated IT. MNPs induced a significant DNA damage in IT treated ESC. While a significant DNA damage was detected in the liver of the IP treated group, but no significant DNA damage could be detected in the brain. Histopathological findings in ESC revealed a marked tumor necrosis, 50% in group injected IT but 40% in group injected IP and 20% only in untreated tumors. Other findings include inflammatory cell infiltration, dilatation, and congestion of blood vessels of different organs of treated groups in addition to appearance of metastatic cancer cells in the liver of non-treated tumor group. MNPs could have an antitumor effect but it is recommended to be injected intratumorally to be directed to the tumor tissues and reduce its adverse effects on healthy tissues.


Author(s):  
Yanbing Zhao ◽  
Huan Zhang ◽  
Dezheng Hao ◽  
Jinglu Wang ◽  
Ding Zhang ◽  
...  
Keyword(s):  

Sign in / Sign up

Export Citation Format

Share Document