Calcium Channel Blocking Drugs as Antihypertensive Agents

1989 ◽  
pp. 89-113
Author(s):  
Austin E. Doyle
Keyword(s):  
Calcium Channel ◽  
Antihypertensive Agents ◽  
Channel Blocking

Calcium Metabolism, Calcium-Channel Blocking Agents, and Hypertension Management

1988 ◽  
Vol 22 (9) ◽  
pp. 659-671 ◽  
Author(s):  
Y.W. Francis Lam
Keyword(s):  
Calcium Channel ◽  
Systemic Vascular Resistance ◽  
Vascular Resistance ◽  
Calcium Channel Blockers ◽  
Calcium Metabolism ◽  
Antihypertensive Agents ◽  
Channel Blockers ◽  
Blocking Agents ◽  
Calcium Channel Blocking Agents ◽  
Channel Blocking

Increasing evidence has suggested that a disturbance of cellular calcium metabolism may have a role in initiating and maintaining elevated systemic vascular resistance in essential hypertension. Controversy exists over whether calcium can alleviate or exacerbate the hypertensive process, and diversity of calcium metabolism in hypertensive patients has been proposed. Calcium-channel blocking agents are potent vasodilators capable of correcting the elevated systemic vascular resistance. Clinical studies have shown that these drugs have antihypertensive efficacy comparable to established agents. The elderly, blacks, and patients with low renin activity respond well to calcium-channel blockers. These drugs may also offer potential advantages over established antihypertensive agents in patients with other coexisting diseases. Sustained release formulations have been developed, and initial experience with long-term efficacy and tolerability is encouraging. The calcium-channel blockers may become first-line therapy for treatment of hypertension in selected patients.

scholarly journals Comparative Pharmacodynamics of Eight Calcium Channel Blocking Agents in Japanese Essential Hypertensive Patients.

1996 ◽  
Vol 19 (3) ◽  
pp. 430-437 ◽  
Author(s):  
Shuji SHIMADA ◽  
Yukiko NAKAJIMA ◽  
Koujirou YAMAMOTO ◽  
Yasufumi SAWADA ◽  
Tatsuji IGA
Keyword(s):  
Calcium Channel ◽  
Hypertensive Patients ◽  
Blocking Agents ◽  
Calcium Channel Blocking Agents ◽  
Channel Blocking

Cellular actions and pharmacology of the calcium channel blocking drugs

1985 ◽  
Vol 79 (4) ◽  
pp. 2-10 ◽  
Author(s):  
Arnold M. Katz ◽  
W.David Hager ◽  
Frank C. Messineo ◽  
Achilles J. Pappano
Keyword(s):  
Calcium Channel ◽  
Channel Blocking

Synthesis and Evaluation of a New Class of Nifedipine Analogs with T-Type Calcium Channel Blocking Activity

2002 ◽  
Vol 61 (3) ◽  
pp. 649-658 ◽  
Author(s):  
P. Phani Kumar ◽  
Stephanie C. Stotz ◽  
R. Paramashivappa ◽  
Aaron M. Beedle ◽  
Gerald W. Zamponi ◽  
...  
Keyword(s):  
Calcium Channel ◽  
New Class ◽  
Channel Blocking ◽  
Blocking Activity
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