Radiation — Induced Genetic Damage and the Prostaglandin System

1988 ◽  
pp. 107-118
Author(s):  
U. N. Das ◽  
G. Rama Devi
Keyword(s):  
Genetic Damage ◽  
Radiation Induced ◽  
Prostaglandin System

Modification of Radiation-Induced Genetic Damage

Nature ◽  
1956 ◽  
Vol 177 (4512) ◽  
pp. 726-730 ◽  
Author(s):  
ALEXANDER HOLLAENDER ◽  
R. F. KIMBALL
Keyword(s):  
Genetic Damage ◽  
Radiation Induced

IN VITRO EVALUATION FOR PROTECTIVE EFFECT OF BAMBOO LEAVES AGAINST GAMMA RADIATION INDUCED GENETIC DAMAGE AND THEIR POLYPHENOLS QUANTIFICATION USING RP-HPLC

INDIAN DRUGS ◽  
2020 ◽  
Vol 57 (01) ◽  
pp. 27-36
Author(s):  
Mansi Patel ◽  
Shikha Tewari ◽  
Dhara Bhayani ◽  
Sonal Bakshi ◽  
Snehal Patel ◽  
...  
Keyword(s):  
Gamma Radiation ◽  
Human Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Genetic Damage ◽  
Rp Hplc ◽  
Bamboo Leaves ◽  
Anti Cancer ◽  
Radiation Induced ◽  
Pre Treatment

Radioprotector is the prime antidote to radiation injury. The desire to search an ideal radioprotector led us to explore natural sources. Bamboo species are known for theirimmense medicinal potential such as antioxidant, anti-inflammatory, anti-cancer, immunomodulatory activities and are enriched with polyphenolic phytoconstituents. In CBMN assay, the pre-treatment of human peripheral blood lymphocytes with varying concentration of bamboo leaf extract before exposure to different doses of γ- radiation resulted in significant (P < 0.0001) decline of radiation induced micronuclei. Among all the selected species, Bambusa arundinacea showed highest protection ~70% at 9 μg/mL concentration. Through RP-HPLC analysis, compared to other species, B. arundinacea showed presence of all selected polyphenols to the highest extent. The results favour the direct correlation of radioprotective activity and the amount of polyphenol, indicating the role of bamboo polyphenols as radioprotector against gamma radiation induced genetic damage.

When Benign Becomes Cancer: Malignant Degeneration of Chronic Inflammation

2021 ◽  
Author(s):  
Christopher Conlon ◽  
Lauren Pupa ◽  
Edward M. Reece ◽  
Carrie K. Chu ◽  
Jessie Z. Yu ◽  
...  
Keyword(s):  
Chronic Inflammation ◽  
Inflammatory Reaction ◽  
Cell Lymphoma ◽  
Breast Implant ◽  
Large Cell ◽  
Malignant Degeneration ◽  
Genetic Damage ◽  
Inflammatory Cascade ◽  
Radiation Induced ◽  
Large Cell Lymphoma

AbstractChronic inflammation, long implicated in the genesis of malignancy, is now understood to underlie an estimated 25% of all cancers. The most pertinent malignancies, to the plastic surgeon, associated with the degeneration of chronic inflammation include Marjolin's ulcer, breast implant-associated large cell lymphoma, radiation-induced sarcoma, and Kaposi's sarcoma. The cellular and genetic damage incurred by a prolonged inflammatory reaction is controlled by an increasingly understood cytokinetic system. Advances in understanding the chronic inflammatory cascade have yielded new therapeutics and therapeutic targets.

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