Techniques for Separation of Neurons and Glia and Their Application to Metabolic Studies

Metabolic studies of marine sterols by Copepods

Planta Medica ◽

10.1055/s-0032-1320354 ◽

2012 ◽

Vol 78 (11) ◽

Author(s):

JL Giner ◽

GH Wikfors ◽

RP Hassett

Keyword(s):

Metabolic Studies

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Metabolic Studies of Vitamin K1-14C and Menadione-14C in the Normal and Hepatectomized Rats

Thrombosis and Haemostasis ◽

10.1055/s-0038-1651216 ◽

1968 ◽

Vol 19 (03/04) ◽

pp. 383-388 ◽

Cited By ~ 6

Author(s):

R Losito ◽

C. A Owen ◽

E. V Flock ◽

Keyword(s):

Enzymatic Hydrolysis ◽

Oral Anticoagulants ◽

Urinary Metabolites ◽

The Other ◽

Vitamin K1 ◽

Vitamin K3 ◽

Metabolic Studies ◽

Intact Rats

SummaryThe metabolism of vitamin K1- 14C and menadione-14C (vitamin K3-14C) was studied in normal and hepateetomized rats. After the administration of menadione, about 70% of the 14C was excreted in the urine in 24 hrs in both types of rats. Two urinary metabolites were identified by enzymatic hydrolysis: one a glucuronide and the other a sulfate of reduced menadione. Thus, the liver is not necessary for the metabolism of menadione. In the vitamin K1 studies, the intact rats excreted only 10% of the 14C and the hepatectomized rats excreted less than 0.5%. The retention of vitamin K1 may explain its superiority over menadione as an antidote for overdosages of oral anticoagulants.

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METABOLIC STUDIES WITH METHANDROSTENOLONE (17β-HYDROXY-17α-METHYL-ANDROSTA-1,4-DIEN-3-ONE) IN HUMAN SUBJECTS

Acta Endocrinologica ◽

10.1530/acta.0.0380413 ◽

1961 ◽

Vol 38 (3) ◽

pp. 413-418 ◽

Cited By ~ 10

Author(s):

S. Almqvist ◽

D. Ikkos ◽

R. Luft

Keyword(s):

Urinary Excretion ◽

Testosterone Propionate ◽

Human Subjects ◽

Calcium Retention ◽

Metabolic Studies ◽

Daily Dose

ABSTRACT The effect of graded doses (5, 10 and 25 mg/d of methandrostenolone and of 25 mg/d of testosterone propionate were compared in each of three metabolically stable adult subjects. Five mg/d of methandrostenolone induced nitrogen and calcium retention. The effects observed with larger doses of methandrostenolone (10 and 25 mg/d) were not quantitatively different from those with 5 mg/d. The nitrogen and calcium retention obtained with the daily dose of 5 mg of methandrostenolone was as great or greater than that induced by testosterone propionate (25 mg/d). Methandrostenolone induced creatinuria but had no effect on sodium and chloride balances and urinary excretion of 17-ketosteroids.

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