Historical Perspectives of Atrial Specific Granules

1987 ◽  
pp. 1-5 ◽  
Author(s):  
Adolfo J. De Bold
Keyword(s):  
Historical Perspectives ◽  
Specific Granules ◽  
Atrial Specific Granules

Atrial-specific granules in the hearts of normal and water-deprived rats

1988 ◽  
Vol 253 (3) ◽  
pp. 547-552 ◽  
Author(s):  
Hirotaka Toshimori ◽  
Kiyotaka Toshimori ◽  
Shigeru Matsukura ◽  
Chikayoshi Ōura ◽  
Hisayuki Matsuo
Keyword(s):  
Specific Granules ◽  
Atrial Specific Granules

Synthesis and renal activity of rat atrial granules depend on extracellular volume

1984 ◽  
Vol 247 (4) ◽  
pp. R750-R752
Author(s):  
U. Ackermann ◽  
T. G. Irizawa
Keyword(s):  
Atrial Natriuretic Factor ◽  
Extracellular Volume ◽  
Extracellular Fluid ◽  
Fluid Volume ◽  
Extracellular Fluid Volume ◽  
Deoxycorticosterone Acetate ◽  
Natriuretic Factor ◽  
Specific Granules ◽  
Atrial Specific Granules ◽  
Natriuretic Effect

Extracellular fluid volume (by 22Na) and extent of 4-h [3H]fucose incorporation into atrial-specific granules were measured in deoxycorticosterone acetate (DOCA)/salt-loaded or Na-deficient rats. The natriuretic potency of extracts from their atria was also measured in assay rats. DOCA/salt-treated animals had a significantly greater extracellular volume, a significantly greater degree of fucose uptake, and a significantly more potent diuretic and natriuretic effect than did Na-deficient rats. These observations, together with the known decrease in atrial granularity with DOCA treatment, suggest that a chronic increase in extracellular fluid volume is associated with increased synthesis and metabolism of atrial natriuretic factor. They also confirm the finding reported by others that granularity and natriuretic potency are not always directly related. It may be that visible granules represent a peptide storage form that requires further processing to become natriuretic.

Fine structure of the impulse-conducting system in rat heart

1970 ◽  
Vol 48 (4) ◽  
pp. 837-839 ◽  
Author(s):  
Haukur Melax ◽  
Thomas S. Leeson
Keyword(s):  
Sinoatrial Node ◽  
Atrioventricular Node ◽  
Nerve Fibers ◽  
Cardiac Cells ◽  
Loose Connective Tissue ◽  
Cardiac Muscle Cells ◽  
Myelinated Nerve ◽  
Specific Granules ◽  
Atrial Specific Granules ◽  
Unmyelinated Nerve

The sinoatrial node of the rat is composed of loosely interwoven modified cardiac muscle cells, which are lined up in groups to form somewhat irregular layers or plates. A generous amount of atrial specific granules is found in their cytoplasm. Between the nodal cells there is a loose connective tissue containing numerous bundles of unit fibrils of collagen and unmyelinated nerve fibers. In the atrioventricular node the modified cardiac cells are larger than those of the sinoatrial node, and are arranged in small groups. They contain a large amount of glycogen. Unmyelinated nerve fibers are extremely numerous in the atrioventricular node and myelinated nerve fibers are also present.

Sign in / Sign up

Export Citation Format

Share Document