atrial natriuretic factor
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2021 ◽  
Author(s):  
Xiang Li ◽  
Cheng-xi Wei ◽  
Cheng-zhe Wu ◽  
Lan Hong ◽  
Zhuo-na Han ◽  
...  

2016 ◽  
Vol 28 (2) ◽  
Author(s):  
Ana Paula Devite Cardoso Gasparotto ◽  
Antonio Luis Eiras Falcão ◽  
Carolina Kosour ◽  
Sebastião Araújo ◽  
Eliane Araújo Cintra ◽  
...  

2015 ◽  
Vol 66 (2) ◽  
pp. 165-170 ◽  
Author(s):  
Ante Miličević ◽  
Nenad Raos

Abstract Using molecular graph theory we studied the binding of NSFRY-NH2 and 12 related pentapeptide amides to Cu(II) as a model system for atrial natriuretic factor (ANF) peptide interactions with copper. Linear regression models based on the valence connectivity index of the 3rd order (3χv) reproduced experimental stability constants (log β) for 1N, 2N, 3N, and 4N coordinated complexes with the standard error of 0.30-0.39 log β units. We developed separate models for seven tyrosinic (N=28) and five non-tyrosinic peptides (N=20), and a common model for both kinds of peptides (N=48) with an indicator (dummy) variable. The results indicate additional aromatic stabilisation in 4N complexes due to metal cation-π interactions with tyrosine but not with the phenylalanine residue. We have also amended the log K and log K* values to correct miscalculations published by Janicka-Klos et al. in 2013


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