Regulation of Proteolysis in Vascular Remodeling

2013 ◽  
pp. 295-319
Author(s):  
Erin R. Mandel ◽  
Cassandra Uchida ◽  
Tara L. Haas
Keyword(s):  
Vascular Remodeling

Morphometric analysis of pulmonary vascular remodeling in COPD

Pneumologie ◽  
2009 ◽  
Vol 63 (02) ◽  
Author(s):  
T Medebach ◽  
N Weissmann ◽  
HA Ghofrani ◽  
W Seeger ◽  
F Grimminger
Keyword(s):  
Morphometric Analysis ◽  
Vascular Remodeling ◽  
Pulmonary Vascular Remodeling

Model Characterization of Pulmonary Arterial Hypertension: Analysis of Lung Pathology with Respect to Human Disease

2020 ◽  
Author(s):  
◽  
Eptisam lambu
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Human Disease ◽  
Vascular Remodeling ◽  
Vascular Wall ◽  
Lung Pathology ◽  
Pulmonary Arterial ◽  
Lung Pathogenesis ◽  
Arterial Endothelial Cells

Pulmonary arterial hypertension (PAH) is a rare multifactorial disease characterized by abnormal high blood pressure in the pulmonary artery, or increased pulmonary vascular resistance (PVR), caused by obstruction in the small arteries of the lung. Increased PVR is also thought to be caused by abnormal vascular remodeling, due to thickening of the pulmonary vascular wall resulting from significant hypertrophy of pulmonary arterial smooth-muscle cells (PASMCs) and increased proliferation/impaired apoptosis of pulmonary arterial endothelial cells (PAECs). Herein, we investigated the mechanisms and explored molecular pathways mediating the lung pathogenesis in two PAH rat models: Monocrotaline (MCT) and Sugen5416/Hypoxia (SuHx). We analyzed these disease models to determine where the vasculature shows the most severe PAH pathology and which model best recapitulates the human disease. We investigated the role vascular remodeling, hypoxia, cell proliferation, apoptosis, DNA damage and inflammation play in the pathogenesis of PAH. Neither model recapitulated all features of the human disease, however each model presented with some of the pathology seen in PAH patients.

IgE mediates broncho-vascular remodeling after neonatal sensitization in mice

10.2741/773 ◽  
2016 ◽  
Vol 8 (3) ◽  
pp. 370-377
Author(s):  
Heber C Nielsen
Keyword(s):  
Vascular Remodeling
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