Xenotransplantation: Hyperacute and Delayed Xenograft Rejection

2001 ◽  
pp. 153-173
Author(s):  
Kwabena Mawulawde ◽  
Joren C. Madsen
Keyword(s):  
Xenograft Rejection

Characterisation of the immune response in a neural xenograft rejection paradigm

1997 ◽  
Vol 73 (1-2) ◽  
pp. 135-144 ◽  
Author(s):  
T.M Litchfield ◽  
S.J.O Whiteley ◽  
K.T Yee ◽  
P Tyers ◽  
E.J Usherwood ◽  
...  
Keyword(s):  
Immune Response ◽  
Xenograft Rejection

THE MAIN INFILTRATING CELL IN XENOGRAFT REJECTION IS A CD4+ MACROPHAGE AND NOT A T LYMPHOCYTE

1995 ◽  
Vol 60 (6) ◽  
pp. 594-601 ◽  
Author(s):  
ANNA CARIN WALLGREN ◽  
ALEX KARLSSON-PARRA ◽  
OLLE KORSGREN
Keyword(s):  
T Lymphocyte ◽  
Xenograft Rejection

scholarly journals hESC-derived neural progenitors prevent xenograft rejection through neonatal desensitisation

2016 ◽  
Vol 282 ◽  
pp. 78-85 ◽  
Author(s):  
Andreas Heuer ◽  
Agnete Kirkeby ◽  
Ulrich Pfisterer ◽  
Marie E. Jönsson ◽  
Malin Parmar
Keyword(s):  
Neural Progenitors ◽  
Xenograft Rejection

HYPERACUTE XENOGRAFT REJECTION IN THE SWINE -TO -HUMAN DONOR-RECIPIENT COMBINATION

1994 ◽  
Vol 57 (2) ◽  
pp. 245-248 ◽  
Author(s):  
Zhongxin Zhao ◽  
Jean-Luc Termignon ◽  
Jorge Cardoso ◽  
Christiane Chéreau ◽  
Chantal Gautreau ◽  
...  
Keyword(s):  
Human Donor ◽  
Xenograft Rejection ◽  
Hyperacute Xenograft Rejection

The Influence of Baseline Expression of Human Decay Accelerating Factor Transgene on Graft Survival and Acute Humoral Xenograft Rejection

2005 ◽  
Vol 80 (9) ◽  
pp. 1331-1339 ◽  
Author(s):  
Hongtao Sun ◽  
Gang Chen ◽  
Weihua Liu ◽  
Dalibor Kubelik ◽  
Hongji Yang ◽  
...  
Keyword(s):  
Graft Survival ◽  
Decay Accelerating Factor ◽  
Xenograft Rejection

scholarly journals The Potential Role of Human NME1 in Neuronal Differentiation of Porcine Mesenchymal Stem Cells: Application of NB-hNME1 as a Human NME1 Suppressor

2021 ◽  
Vol 22 (22) ◽  
pp. 12194
Author(s):  
Jin Hyoung Cho ◽  
Won Seok Ju ◽  
Sang Young Seo ◽  
Bo Hyun Kim ◽  
Ji-Su Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Neuronal Differentiation ◽  
Nucleoside Diphosphate Kinase ◽  
Inhibitory Effect ◽  
Human Macrophage ◽  
Potential Candidate ◽  
Xenograft Rejection ◽  
Ganglioside Gd3

This study aimed to investigate the effects of the human macrophage (MP) secretome in cellular xenograft rejection. The role of human nucleoside diphosphate kinase A (hNME1), from the secretome of MPs involved in the neuronal differentiation of miniature pig adipose tissue-derived mesenchymal stem cells (mp AD-MSCs), was evaluated by proteomic analysis. Herein, we first demonstrate that hNME1 strongly binds to porcine ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (pST8SIA1), which is a ganglioside GD3 synthase. When hNME1 binds with pST8SIA1, it induces degradation of pST8SIA1 in mp AD-MSCs, thereby inhibiting the expression of ganglioside GD3 followed by decreased neuronal differentiation of mp AD-MSCs. Therefore, we produced nanobodies (NBs) named NB-hNME1 that bind to hNME1 specifically, and the inhibitory effect of NB-hNME1 was evaluated for blocking the binding between hNME1 and pST8SIA1. Consequently, NB-hNME1 effectively blocked the binding of hNME1 to pST8SIA1, thereby recovering the expression of ganglioside GD3 and neuronal differentiation of mp AD-MSCs. Our findings suggest that mp AD-MSCs could be a potential candidate for use as an additive, such as an immunosuppressant, in stem cell transplantation.

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