Proton MR Spectroscopic Imaging in The Investigation of Patients with Temporal Lobe Epilepsy

1994 ◽  
pp. 203-207 ◽  
Author(s):  
F. Cendes ◽  
F. Andermann ◽  
D. L. Arnold
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Spectroscopic Imaging ◽  
Mr Spectroscopic Imaging

Normalization of neuronal metabolic dysfunction after surgery for temporal lobe epilepsy: Evidence from proton MR spectroscopic imaging

Neurology ◽  
1997 ◽  
Vol 49 (6) ◽  
pp. 1525-1533 ◽  
Author(s):  
F. Cendes ◽  
F. Andermann ◽  
F. Dubeau ◽  
P. M. Matthews ◽  
D. L. Arnold
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Spectroscopic Imaging ◽  
Metabolic Dysfunction ◽  
Mr Spectroscopic Imaging

scholarly journals Temporal lobe epilepsy: bilateral hippocampal metabolite changes revealed at proton MR spectroscopic imaging.

Radiology ◽  
1997 ◽  
Vol 202 (3) ◽  
pp. 809-817 ◽  
Author(s):  
G R Ende ◽  
K D Laxer ◽  
R C Knowlton ◽  
G B Matson ◽  
N Schuff ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Spectroscopic Imaging ◽  
Mr Spectroscopic Imaging

Application of high field spectroscopic imaging in the evaluation of temporal lobe epilepsy

1995 ◽  
Vol 13 (8) ◽  
pp. 1175-1180 ◽  
Author(s):  
H.P. Hetherington ◽  
R.I. Kuzniecky ◽  
J.W. Pan ◽  
J.T. Vaughan ◽  
D.B. Tweig ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
High Field ◽  
Spectroscopic Imaging

Lateralization of human temporal lobe epilepsy by 31P NMR spectroscopic imaging at 4.1 T

Neurology ◽  
1998 ◽  
Vol 51 (2) ◽  
pp. 472-479 ◽  
Author(s):  
W.-J. Chu ◽  
H. P. Hetherington ◽  
R. I. Kuzniecky ◽  
T. Simor ◽  
G. F. Mason ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Healthy Volunteers ◽  
Temporal Lobe ◽  
Imaging System ◽  
Spectroscopic Imaging ◽  
Whole Body ◽  
Noninvasive Methods ◽  
Seizure Focus ◽  
Volume Coil ◽  
Mesial Temporal Lobe

Objective: To compare the phosphorous metabolite ratios in the mesial temporal lobe of healthy volunteers (n = 20) with the corresponding ratios in patients with temporal lobe epilepsy (n = 30) using 31P NMR spectroscopic imaging and to lateralize the seizure focus in temporal lobe epilepsy patients using various phosphorous metabolite ratios-phosphocreatine to inorganic phosphate(PCr/Pi), PCr to adenosine triphosphate (PCr/γ-ATP), and(γ-ATP/Pi)-and to compare with clinical lateralization results.Methods: All 31P NMR spectroscopic imaging studies were performed on a high-field, 4.1 T, whole-body NMR spectroscopic imaging system using a31 P/1H double-tuned volume coil.Results: We found an average reduction of 15% in the PCr/Pi and γ-ATP/Pi ratios compared with the corresponding ratios in healthy volunteers in the entire mesial temporal lobe, and more than a 30% reduction in these two ratios in the anterior region of the epileptogenic mesial temporal lobe. These ratios were also reduced significantly in the ipsilateral lobe when compared with their corresponding values in the contralateral lobe. In patients we lateralized the seizure focus, based on these 31P NMR data, and compared the results with the clinical lateralization. The lateralization based on either the PCr/Pi or the γ-ATP/Pi ratio yielded a correspondence of 70 to 73% with the final clinical lateralization. In the subgroup of patients (n = 9) that needed intracranial EEG for the presurgical lateralization because of inconclusive results from the noninvasive methods, a 78% correspondence was found with the 31P NMR-based lateralization, whereas MRI provided a correspondence of only 33%, and scalp EEG provided a correspondence of only 56%.Conclusions: These results suggest the utility of adding the 31P NMR method to the group of noninvasive modalities used for presurgical decision making in temporal lobe epilepsy patients.

scholarly journals EEG Background Delta Activity in Temporal Lobe Epilepsy: Correlation with Volumetric and Spectroscopic Imaging

Epilepsia ◽  
1999 ◽  
Vol 40 (11) ◽  
pp. 1580-1586 ◽  
Author(s):  
Andrea Bernasconi ◽  
Fernando Cendes ◽  
Jong Lee ◽  
D. C. Reutens ◽  
Jean Gotman
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Spectroscopic Imaging ◽  
Delta Activity
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