spectroscopic imaging
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2022 ◽  
pp. 000370282110614
Author(s):  
Qi Cheng ◽  
Yongzheng Zhu ◽  
Kaifei Deng ◽  
Zhiqiang Qin ◽  
Jianhua Zhang ◽  
...  

The diagnosis of pulmonary fat embolism (PFE) is of great significance in the field of forensic medicine because it can be considered a major cause of death or a vital reaction. Conventional histological analysis of lung tissue specimens is a widely used method for PFE diagnosis. However, variable and labor-intensive tissue staining procedures impede the validity and informativeness of histological image analysis. To obtain complete information from tissues, a method based on infrared imaging of unlabeled tissue sections was developed to identify pulmonary fat emboli in the present study. We selected 15 PFE-positive lung samples and 15 PFE-negative samples from real cases. Oil red O (ORO) staining and infrared spectral imaging collection were both performed on all lung tissue samples. And the fatty tissue of the abdominal wall and the embolized lipid droplets in the lungs were taken for comparison. The results of the blind, evaluation by pathologists, showed good agreement between the infrared spectral imaging of the lung tissue and the standard histological stained images. Fourier transform infrared (FT-IR) spectroscopic imaging significantly simplifies the typical painstakingly laborious histological staining procedure. And we found a difference between lipid droplets embolized in abdominal wall fat and lung tissue.


Radiology ◽  
2022 ◽  
Author(s):  
Eva Heckova ◽  
Assunta Dal-Bianco ◽  
Bernhard Strasser ◽  
Gilbert J. Hangel ◽  
Alexandra Lipka ◽  
...  

2022 ◽  
Author(s):  
Pablo C. Bueno ◽  
Nicholas Mueschke ◽  
Elijah LaLonde ◽  
Christopher S. Combs

2022 ◽  
Vol 17 (01) ◽  
pp. P01012
Author(s):  
L. Jowitt ◽  
M. Wilson ◽  
P. Seller ◽  
C. Angelsen ◽  
R.M. Wheater ◽  
...  

Abstract HEXITEC is a spectroscopic imaging X-ray detector technology developed at the STFC Rutherford Appleton Laboratory for X-ray and γ-ray spectroscopic imaging applications. Each module has 80 × 80 pixels on a 250 μm pixel pitch, and has been implemented successfully in a number of applications. This paper presents the HEXITEC 2 × 2 detector system, a tiled array of 4 HEXITEC modules read out simultaneously, which provides an active area of 16 cm2. Systems have been produced using 1 mm thick Cadmium Telluride (CdTe) and 2 mm thick Cadmium Zinc Telluride (CdZnTe) sensor material. In this paper the system and data processing methods are presented, and the performance of the systems are evaluated. The detectors were energy calibrated using an 241Am sealed source. Three types of charge sharing correction were applied to the data-charge sharing addition (CSA), charge sharing discrimination (CSD), and energy curve correction (ECC) which compensates for energy lost in the inter-pixel region. ECC recovers an additional 34 % of counts in the 59.5 keV peak in CdTe compared to the use of CSD; an important improvement for photon-starved applications. Due to the high frame rate of the camera system (6.3 kHz) an additional End of Frame (EOF) correction was also applied to 6.0 % of events to correct for signals that were readout whilst the signal was still forming. After correction, both detector materials were found to have excellent spectroscopic performance with a mean energy resolution (FWHM) of 1.17 keV and 1.16 keV for CdZnTe and CdTe respectively. These results successfully demonstrate the ability to construct tiled arrays of HEXITEC modules to provide larger imaging areas.


Author(s):  
Cornelius Morze ◽  
Tyler Blazey ◽  
Richard Baeza ◽  
Ruslan Garipov ◽  
Timothy Whitehead ◽  
...  

2021 ◽  
Author(s):  
Nienke Bosschaart ◽  
Johanna R. de Wolf ◽  
Sjoukje M. Schoustra ◽  
Miriam van de Hoek ◽  
Anais Leproux ◽  
...  

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