Effects of Chlorothiazide Administration and Dietary Calcium Restriction on Parathyroid Function, Vitamin D Metabolism and Intestinal Calcium Absorption in the Rat

Author(s):  
Murray J. Favus ◽  
Fredric L. Coe ◽  
Satish C. Kathpalia ◽  
Asher Porat ◽  
Prabir K. Sen ◽  
...  
1982 ◽  
Vol 94 (3) ◽  
pp. 443-453 ◽  
Author(s):  
C. J. Robinson ◽  
E. Spanos ◽  
M. F. James ◽  
J. W. Pike ◽  
M. R. Haussler ◽  
...  

Intestinal calcium absorption and plasma levels of 1,25-dihydroxycholecalciferol (1,25(OH)2D3) were measured in lactating and non-lactating rats and the effects of bromocriptine and exogenous prolactin treatment were evaluated. In lactating rats calcium absorption and plasma levels of parathyroid hormone, 1,25(OH)2D3 and alkaline phosphatase activity were significantly increased. Bromocriptine treatment significantly reduced the enhanced calcium absorption and levels of plasma 1,25(OH)2D3 and alkaline phosphatase but had no significant effect on plasma levels of parathyroid hormone. Prolactin administered with bromocriptine to lactating animals prevented all the changes observed with bromocriptine treatment alone. It was concluded that the increased plasma levels of prolactin during lactation lead to high plasma levels of 1,25(OH)2D3 which are responsible for the enhanced intestinal calcium absorption.


1996 ◽  
Vol 211 (3) ◽  
pp. 281-286 ◽  
Author(s):  
H. P. Schedl ◽  
T. Conway ◽  
R. L. Horst ◽  
D. L. Miller ◽  
C. K. Brown

1982 ◽  
Vol 4 (1) ◽  
pp. 75???86
Author(s):  
Milton M. Weiser ◽  
John H. Bloor ◽  
Amita Dasmahapatra

1982 ◽  
Vol 4 (1) ◽  
pp. 75-86 ◽  
Author(s):  
Milton M. Weiser ◽  
John H. Bloor ◽  
Amita Dasmahapatra

Endocrinology ◽  
1989 ◽  
Vol 124 (2) ◽  
pp. 565-572 ◽  
Author(s):  
BULANGU L. NYOMBA ◽  
JOHAN VERHAEGHE ◽  
MONIQUE THOMASSET ◽  
WILLY LISSENS ◽  
ROGER BOUILLON

1985 ◽  
Vol 23 (5) ◽  
pp. 511-515 ◽  
Author(s):  
J. H. KRISTIANSEN ◽  
P. RØDBRO ◽  
C. CHRISTIANSEN ◽  
J. BRØCHNER MORTENSEN ◽  
J. CARL

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