The Influence of Highly Dispersed Metal Forms on Calcium and Phosphorus Metabolism in Polygastric Animals

Determining which forms of mineral feed additives can increase farm animal productivity is a key area of research. This study assessed the mineral composition of ruminal fluid and the effectiveness of calcium and phosphorus used by animals after the introduction of finely dispersed particles (FDP) of SiO2 (group I) and FeCo (group II) with a hydrodynamic radius of 109.6 ± 16.6 and 265 ± 25 nm, respectively. The deposition and use of calcium and phosphorus in the body of the experimental animals exceeded the control values. In group I, 30.8% more calcium was deposited (p ≥ 0.05), and in group II, the value was 30.3% (p ≥ 0.01). In the experimental groups, the calcium utilization rate was 27.3% higher in group I (p ≥ 0.05), and 28.2% higher in group II (p ≥ 0.01) compared to in the control. Phosphorus deposition was 34% higher (p ≤ 0.01) in experimental group I and 6% higher in experimental group II, compared with the control. Group I had a high utilization rate of phosphorus from the feed (with a 29% difference compared to the control). Comparison of the experimental groups revealed that the introduction of SiO2 FDP promoted an increase in the concentration of silicon, phosphorus, and calcium in the ruminal fluid. The introduction of FeCo FDP was accompanied by a decrease in the concentration of iron and cobalt in the ruminal fluid. Thus, the use of feed additive in finely dispersed form in the diet of animals was accompanied by an increase in the use of calcium and phosphorus by the animal’s body, which is advisable when intensifying milk and meat productivity. The obtained results require further research. Keywords: finely dispersed forms of microelements, ruminants, calcium and phosphorus exchange, feeding

Recommend-Response and Complications Comparing Radiofrequency Ablation Versus Parathyroidectomy for Secondary Hyperparathyroidism in Dialysis Patients

Introduction : To compare the efficacy and safety of ultrasound(US)-guided radiofrequency ablation (RFA) and parathyroidectomy (PTX) in the treatment of secondary hyperparathyroidism (SHPT). Methods In this retrospective study, we divided patients into PTX (n=53) and RFA (n=47) groups. The primary outcomes were the proportion of patients achieved the target range of iPTH concentrations(124-558pg/mL) and the long-term prognosis. The secondary outcomes were the differences in the changes of iPTH, calcium, and phosphorus over time and the incidence of adverse events. Results There was rarely difference in baseline characteristics between the two groups. Primary outcomes: The iPTH concentrations of 25.8% of patients in the PTX group and 51.3% of the RFA group were within the recommended range at the endpoint (P=0.031). Survival analysis revealed that the difference in all-cause mortality and cumulative response rate between the two groups was not statistically significant (P=0.902, P=0.141, respectively). Secondary outcomes: The iPTH concentrations in PTX group and RFA group dropped sharply after treatment and were 82.30±163.21pg/mL and 279.96±306.57pg/mL (P<0.001). There was no difference in the trend of iPTH, calcium, and phosphorus levels between the two groups over time(P>0.05). In addition, the incidence of infection and the hospital stay in the RFA group were significantly less. And preoperative bone-specific alkaline phosphatase concentration was a risk factor for postoperative hypocalcemia. Conclusion US-guided RFA was minimally invasive and no less than PTX in terms of cumulative response rate and complications in the treatment of severe SHPT in maintenance dialysis patients and may be used as an alternative technique to PTX, which need further studies to confirm.

Diluted Acetic Acid Softened Intermuscular Bones from Silver Carp (Hypophthalmichthys molitrix) by Dissolving Hydroxyapatite and Collagen

Intermuscular bones (IBs) pose physical hazards that threaten consumer health and food safety. This study aimed to investigate the mechanism of softening IBs from silver carp with diluted acetic acid. IBs (separated from muscle) and fillets (without removing IBs) were treated with diluted acetic acid. Analyses of sensory attributes and the hardness of treated IBs indicated that diluted acetic acid (<10 mmol/L) could soften IBs effectively. Additionally, 0.5 mmol/L acetic acid softened IBs within fillets without significantly affecting the texture and flavor of fillets. Analyses of microstructure, minerals (calcium and phosphorus) and collagen content, and the Fourier transform infrared (FTIR) spectra of IBs indicated that acetic acid broke connections (formed by collagen that shared hydroxyl groups) between collagen molecules, and between collagen and hydroxyapatite (HAP), thus inducing the dissolution of collagen and HAP. The dissolution of HAP contributed more to IBs softening than collagen.

The study of the calcium and phosphorus metabolism impact on the development of demineralized enamel areas in adolescents

Relevance. The article presents the current data on the impact of calcium and phosphorus metabolism on the development of demineralized enamel areas in adolescents. The level of vitamin D3, osteocalcin, bone alkaline phosphatase isoenzyme and parathyroid hormone (PTH) in mixed saliva appeared to reflect the risk of the cariogenic situation in the oral cavity and the risk of enamel demineralization development, which are relevant in pediatric dentistry. Purpose – to reveal the relationship between the localized enamel demineralization and the calcium and phosphorus metabolism in teenagers.Materials and methods. In 45 adolescents, the study examined the vulnerability of hard dental tissues, including initial lesions and the mixed saliva mineral metabolism in teenagers. We formed the following groups to study the caries intensity level. Group 1 consisted of 12 adolescents with a DMF index of 3.8. 11 adolescents comprised group 2 and 11 adolescents – group 3 with DMF indices of 4.9 and 6.8, respectively; group 4 contained adolescents without caries.Results. The analysis of caries intensity and permanent enamel demineralization areas in adolescents and the main markers of mixed saliva mineralization revealed a correlation between the activity of the initial carious lesions and the calcium and phosphate metabolism.Conclusions. Evaluating the principal markers of calcium and phosphorus metabolism is relevant for the risk assessment of the cariogenic situation or enamel demineralization development in adolescents and preventive treatment planning.

Opuntia ficus-indica the key plant in climate change: characteristics, cultivation and uses

The Opuntia genus, belonging to the Cactaceae family, has about 300 species, of which Opuntia ficus indica, or Prickly Pear, is considered the best known and most significant. Opuntia ficus indica have been used in Mexico and Latin America since pre-hispanic times as a food and medicinal resource. In recent years, prickly pear cultivation has increased mainly because this plant used for food, medicinal and livestock purposes is able to withstand extreme drought conditions in relatively poor soils. The fruits of the prickly pear are of various colours such as yellow, orange, purple and white, and when ripe their sweet pulp is characterised by a low acidity. It possesses numerous nutritional and therapeutic virtues such as richness in carbohydrates, vitamins, minerals and considerable antioxidant, anti-diabetes, anti-cancer fruit activity. Opuntia also has laxative properties due to its soluble fibres and mucilage. The infusion of the harvested and dried flowers has a depurative effect; it has a mild, gentle diuretic and relaxing action on the renal excretory system. Opuntias are also exploited as an alternative and cheap source of source of food for animals and as an ornamental plant. Opuntia ficus indica is grown in subtropical, tropical and warm-temperature areas; it is mainly cultivated in Tunisia, Libya and Egypt. The Prickly Pear finds a particularly favourable habitat in Sardinia, Calabria, Apulia and Sicily, where it is also cultivated, as well as in Spain and North Africa, for the exploitation of its edible fruit, with its delicately sweet pulp, rich in minerals, especially calcium and phosphorus, and vitamin C. In this review, the characteristics, cultivation methods, main uses of the plant and fruits, market and adversities of Opuntia ficus indica are described.

The dietary intake of chronic kidney disease according to stages: Findings from the Korean National Health and Nutritional Examination Survey

Appropriate dietary adjustment in patients with chronic kidney disease (CKD) is important, and nutritional guidelines recommend different dietary management depending on the CKD stage. However, there is no study, to our knowledge, of the characteristics of dietary intake according to CKD stages. We tried to assess the comparison of nutritional intake according to CKD stages. A cross-sectional study was conducted to reveal the characteristics of dietary intake among patients with CKD based on the Korean National Health and Nutritional Examination Survey between 2011 and 2014. Of 16,878 participants, we classified non-CKD (n = 14,952) and CKD (n = 1,926), which was stratified into five groups (I, II, IIIa, IIIb, and IV–V). We investigated the characteristics of dietary intake, such as energy, water, protein, fat, carbohydrate, sodium, potassium, calcium, and phosphorus, according to stage of CKD. We also explored nutritional intake according to CKD stage among patients with early CKD (stage I and II) and advanced CKD (stage IIIa, IIIb, and IV–V). Intake of majority of nutrients and energy tended to be decreased as CKD progressed. In early CKD stage, intake of energy, water, protein, fat, carbohydrate, potassium, calcium and phosphorus seemed to be statistically significant decreased as CKD progressed. In advanced CKD stage, intake of potassium and calcium seemed to be decreased as CKD progressed, but the intake of energy was about to be lower limit. Appropriate dietary education and CKD recognition are needed to improve nutritional intake depending on the CKD stage.

Remote Diagnosis System of Uremia Complicated with Sleep Disorder and Effectiveness of Nursing Intervention

This study aimed to analyze the related factors and remote diagnosis of sleep disorders in patients with uremia and to provide the basis for clinical intervention measures. The Pittsburgh Sleep Quality Index (PSQI) was used to evaluate the sleep quality of 100 patients with uremia. The experimental results show that among 100 patients with uremia, 83 patients (83%) were complicated with sleep disorder, and the average PSQI score was (10.73 ± 1.36). The PSQI score was significantly higher in the elderly, patients with long duration of dialysis, patients with elevated CRP, patients with substandard anemia, and patients with substandard calcium and phosphorus, with statistical significance ( P < 0.05 ). The sleep quality of patients with uremia is correlated with depression, age, and penetration age. The worse the sleep quality is, the more severe the depression is. It proved that the sleep quality of dialysis patients is an important factor. Conclusion. Sleep disorder is a common complication in patients with uremia. Age, anemia, calcium and phosphorus abnormality, permeation age, and inflammatory status are important factors affecting sleep quality in dialysis patients.

Effects of dietary levels of calcium, phosphorus, and 1-alpha-hydroxycholecalciferol on digestibility, retention of calcium and phosphorus, and concentration of metabolizable energy in diets fed to sows in late-gestation

The apparent total tract digestibility and retention of calcium (Ca) and phosphorus (P) and concentrations of digestible energy and metabolizable energy in diets fed to late-gestating sows were not affected by Ca and P levels, but they were increased by dietary supplementation with 1-alpha-hydroxycholecalciferol. There was no interaction between dietary Ca and P and supplementation with 1-alpha-hydroxycholecalciferol.