Lipoxygenase Products and Their Functions in Glomeruli

1989 ◽  
pp. 49-74 ◽  
Author(s):  
Raymond Ardaillou ◽  
Laurent Baud ◽  
Josée Sraer
Keyword(s):  
Lipoxygenase Products

scholarly journals The molecular mechanism of the inhibition by licofelone of the biosynthesis of 5-lipoxygenase products

2007 ◽  
Vol 152 (4) ◽  
pp. 471-480 ◽  
Author(s):  
L Fischer ◽  
M Hornig ◽  
C Pergola ◽  
N Meindl ◽  
L Franke ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Lipoxygenase Products

scholarly journals The inhibitory role of 12- and 15-lipoxygenase products on renin release.

Hypertension ◽  
1987 ◽  
Vol 10 (1) ◽  
pp. 61-66 ◽  
Author(s):  
I Antonipillai ◽  
J L Nadler ◽  
E C Robin ◽  
R Horton
Keyword(s):  
Renin Release ◽  
Inhibitory Role ◽  
Lipoxygenase Products

Diacylglycerols interfere in normal phase HPLC analysis of lipoxygenase products of docosahexaenoic or arachidonic acids

1986 ◽  
Vol 32 (6) ◽  
pp. 813-827 ◽  
Author(s):  
Magda Claeys ◽  
Haydee E.P. Bazan ◽  
Dale L. Birkle ◽  
Nicolas G. Bazan
Keyword(s):  
Hplc Analysis ◽  
Normal Phase ◽  
Lipoxygenase Products ◽  
Normal Phase Hplc ◽  
Arachidonic Acids

Microcirculatory disturbance in indomethacin-induced intestinal ulcer

1991 ◽  
Vol 261 (2) ◽  
pp. G213-G219 ◽  
Author(s):  
S. Miura ◽  
M. Suematsu ◽  
S. Tanaka ◽  
H. Nagata ◽  
S. Houzawa ◽  
...  
Keyword(s):  
Intestinal Mucosa ◽  
Venous Blood ◽  
Leukotriene B4 ◽  
Ulcer Formation ◽  
Myeloperoxidase Activity ◽  
Neutrophil Accumulation ◽  
Intestinal Ulcer ◽  
Leukocyte Accumulation ◽  
Lipoxygenase Products ◽  
Microcirculatory Disturbances

Participation of microcirculatory disturbances, especially the role of 5-lipoxygenase products from neutrophils, was investigated in indomethacin (Indo)-induced ulcers of rat small intestine. After Indo treatment (20 mg/kg) in rats, small erosions appeared at 6 h and longitudinal ulcers developed 12 h later. At 6 and 12 h after Indo treatment, severe microcirculatory disturbances were observed under an intravital fluorescence microscope. Significant delay in the clearance and patchy pooling of injected fluorescein isothiocyanate-bovine serum albumin with sludge and stasis were observed in archade vessels of villi of Indo-treated rats. Increased numbers of sticking leukocytes were also detected along submucosal venules in these rats after the infusion of acridine orange. When regional venous blood was collected from the mesentery, a marked increase in neutrophil number and their increased production of oxygen-derived free radicals as determined by chemiluminescence assay were demonstrated at 6 h after Indo treatment. There was also a significant increase in myeloperoxidase activity of the intestinal mucosa at 6 and 12 h after Indo treatment, suggesting a significant neutrophil accumulation at this time. AA-861, a selective inhibitor of 5-lipoxygenase (80 mg/kg), attenuated these microcirculatory changes and neutrophil accumulation in the intestinal mucosa. AA-861 also significantly prevented the formation of intestinal ulcers induced by Indo. However, Indo-induced ulcer formation and leukocyte accumulation in submucosal venules were not attenuated by the treatment of Ono-1078, a potent antagonist of sulfidopeptide leukotrienes. From these observations, it is considered that microcirculatory disturbances, especially leukocyte accumulation and 5-lipoxygenase products, possibly leukotriene B4, may be involved in the development of Indo-induced intestinal ulcer.

15-Lipoxygenase Products Stimulate Prolactin Secretion from a Cloned Strain of Rat Pituitary Cells

1988 ◽  
Vol 47 (4) ◽  
pp. 323-328 ◽  
Author(s):  
Mireille Rabier ◽  
Claude Chavis ◽  
André Crastes de Paulet ◽  
Marcelle Damon
Keyword(s):  
Prolactin Secretion ◽  
Pituitary Cells ◽  
Rat Pituitary ◽  
Lipoxygenase Products ◽  
Rat Pituitary Cells
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