Adenosine Deaminase and Purine Nucleoside Phosphorylase in Acute and Chronic Lymphatic Leukemia

1980 ◽  
pp. 333-337 ◽  
Author(s):  
Heinz Ludwig ◽  
Heide Winterleitner ◽  
Rudolf Kuzmits ◽  
Mathias M. Müller
Keyword(s):  
Adenosine Deaminase ◽  
Purine Nucleoside Phosphorylase ◽  
Purine Nucleoside ◽  
Chronic Lymphatic Leukemia ◽  
Nucleoside Phosphorylase ◽  
Lymphatic Leukemia

Purine Metabolic Enzymes in Lymphocytes: II. Adenosine Deaminase and Purine Nucleoside Phosphorylase Activities in the Immune Responses

1982 ◽  
Vol 26 (1) ◽  
pp. 87-92 ◽  
Author(s):  
Satonori Kurashige ◽  
Yuki Akuzawa ◽  
Toshiharu Yoshida ◽  
Chisato Teshima ◽  
Kazue Kodama ◽  
...  
Keyword(s):  
Immune Responses ◽  
Adenosine Deaminase ◽  
Purine Nucleoside Phosphorylase ◽  
Metabolic Enzymes ◽  
Purine Nucleoside ◽  
Nucleoside Phosphorylase

Erythrocyte adenosine deaminase and purine nucleoside phosphorylase activity in gout

1975 ◽  
Vol 58 (3) ◽  
pp. 277-282 ◽  
Author(s):  
Tsuneo Nishizawa ◽  
Yutaro Nishida ◽  
Ieo Akaoka ◽  
Takashi Yoshimura
Keyword(s):  
Adenosine Deaminase ◽  
Purine Nucleoside Phosphorylase ◽  
Purine Nucleoside ◽  
Phosphorylase Activity ◽  
Nucleoside Phosphorylase

Modelling of purine nucleoside metabolism during mouse embryonic development. Relative routes of adenosine, deoxyadenosine, and deoxyguanosine metabolism

1996 ◽  
Vol 74 (2) ◽  
pp. 219-225 ◽  
Author(s):  
Jack P. Jenuth ◽  
Ellen R. Mably ◽  
Floyd F. Snyder
Keyword(s):  
Embryonic Development ◽  
Adenosine Deaminase ◽  
Purine Nucleoside Phosphorylase ◽  
Adenosine Kinase ◽  
Purine Nucleoside ◽  
Nucleoside Phosphorylase ◽  
Deoxyguanosine Kinase ◽  
Nucleoside Metabolism ◽  
Michaelis Constants ◽  
The Individual

The individual activities for adenosine kinase, deoxyadenosine kinase, adenosine deaminase, deoxyguanosine kinase, and purine nucleoside phosphorylase were determined during days 7 to 13 of mouse embryonic development. Adenosine deaminase increased 74-fold between days 7 and 9; deoxyadenosine kinase increased 5.4-fold during the same interval. Adenosine kinase, deoxyguanosine kinase, and purine nucleoside phosphorylase exhibited less than 2-fold changes in activity between days 7 and 13. Using Michaelis constants for each enzyme and the maximal velocities determined from enzyme assay, the relative routes of adenosine and deoxyadenosine metabolism via phosphorylation or deamination were modeled as a function of nucleoside concentration for days 7 through 13. For days 7 and 8, phosphorylation of adenosine is the principle route of metabolism at physiological concentrations. A switch occurred at day 9 and following where deamination is at least 5-fold greater than phosphorylation at all substrate concentrations. Deoxyadenosine phosphorylation was at most 10% of deamination at day 7 and then declined to less than 1% for days 9 to 13. Phosphorolysis was the principle route of deoxyguanosine metabolism through the 7 to 13 day period. Thus catabolism rather than phosphorylation was the principle pathway for purine deoxynucleoside metabolism during this period.Key words: mouse embryo, purine nucleoside metabolism.

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