In Vitro Survival of Human Neoplastic Germ Cells

Author(s):  
Ewa Rajpert-De Meyts ◽  
Heidrun Lauke ◽  
Niels E. Skakkebæk
Keyword(s):  
1998 ◽  
Vol 49 (3) ◽  
pp. 521-528 ◽  
Author(s):  
H Shim ◽  
G.B Anderson

2014 ◽  
Author(s):  
Khaled S A Habas ◽  
Diana Anderson ◽  
Martin H Brinkworth

2020 ◽  
Vol 16 ◽  
pp. 138-143
Author(s):  
Peter L. Kench ◽  
Linda Rogers ◽  
Ana Esteves ◽  
Tina Gorjiara ◽  
Elizabeth Claridge Mackonis ◽  
...  
Keyword(s):  

Cell Research ◽  
2021 ◽  
Author(s):  
Xiaoxiao Wang ◽  
Yunlong Xiang ◽  
Yang Yu ◽  
Ran Wang ◽  
Yu Zhang ◽  
...  

AbstractThe pluripotency of mammalian early and late epiblast could be recapitulated by naïve embryonic stem cells (ESCs) and primed epiblast stem cells (EpiSCs), respectively. However, these two states of pluripotency may not be sufficient to reflect the full complexity and developmental potency of the epiblast during mammalian early development. Here we report the establishment of self-renewing formative pluripotent stem cells (fPSCs) which manifest features of epiblast cells poised for gastrulation. fPSCs can be established from different mouse ESCs, pre-/early-gastrula epiblasts and induced PSCs. Similar to pre-/early-gastrula epiblasts, fPSCs show the transcriptomic features of formative pluripotency, which are distinct from naïve ESCs and primed EpiSCs. fPSCs show the unique epigenetic states of E6.5 epiblast, including the super-bivalency of a large set of developmental genes. Just like epiblast cells immediately before gastrulation, fPSCs can efficiently differentiate into three germ layers and primordial germ cells (PGCs) in vitro. Thus, fPSCs highlight the feasibility of using PSCs to explore the development of mammalian epiblast.


2014 ◽  
Vol 55 (2) ◽  
pp. 381-390 ◽  
Author(s):  
Motohiro Yamauchi ◽  
Kensuke Otsuka ◽  
Hisayoshi Kondo ◽  
Nobuyuki Hamada ◽  
Masanori Tomita ◽  
...  

2010 ◽  
Vol 88 (2) ◽  
pp. 279-280 ◽  
Author(s):  
S. Arkle ◽  
D.R. George ◽  
J.H. Guy ◽  
O.A.E. Sparagano

2000 ◽  
Vol 74 (5) ◽  
pp. 1044-1046 ◽  
Author(s):  
Jan Tesarik ◽  
Natalio Cruz-Navarro ◽  
Eduardo Moreno ◽  
Maria Teresa Cañete ◽  
Carmen Mendoza
Keyword(s):  

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