Taurine-Induced Single-Channel Currents in Cultured Rat Cerebellar Granule Cells

1996 ◽  
pp. 455-462 ◽  
Author(s):  
M.-L. Linne ◽  
T. O. Jalonen ◽  
P. Saransaari ◽  
S. S. Oja
Keyword(s):  
Granule Cells ◽  
Single Channel ◽  
Cerebellar Granule Cells ◽  
Cerebellar Granule ◽  
Single Channel Currents ◽  
Channel Currents

scholarly journals Triheteromeric GluN1/GluN2A/GluN2C NMDARs with Unique Single-Channel Properties Are the Dominant Receptor Population in Cerebellar Granule Cells

Neuron ◽  
2018 ◽  
Vol 99 (2) ◽  
pp. 315-328.e5 ◽  
Author(s):  
Subhrajit Bhattacharya ◽  
Alpa Khatri ◽  
Sharon A. Swanger ◽  
John O. DiRaddo ◽  
Feng Yi ◽  
...  
Keyword(s):  
Granule Cells ◽  
Single Channel ◽  
Cerebellar Granule Cells ◽  
Cerebellar Granule ◽  
Channel Properties

Single-channel and whole-cell currents in rat cerebellar granule cells

1990 ◽  
Vol 535 (1) ◽  
pp. 33-38 ◽  
Author(s):  
T. Jalonen ◽  
S. Johansson ◽  
I. Holopainen ◽  
S.S. Oja ◽  
P. A˚rhem
Keyword(s):  
Granule Cells ◽  
Single Channel ◽  
Cerebellar Granule Cells ◽  
Whole Cell ◽  
Cerebellar Granule

scholarly journals Mechanisms of GABAB receptor enhancement of extrasynaptic GABAA receptor currents in cerebellar granule cells

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Shailesh N. Khatri ◽  
Wan-Chen Wu ◽  
Ying Yang ◽  
Jason R. Pugh
Keyword(s):  
Granule Cells ◽  
Single Channel ◽  
Cerebellar Granule Cells ◽  
Gabab Receptor ◽  
Open Probability ◽  
Cerebellar Granule ◽  
Channel Current ◽  
Open Time ◽  
Patch Clamp Electrophysiology ◽  
Channel Open Time

Abstract Many neurons, including cerebellar granule cells, exhibit a tonic GABA current mediated by extrasynaptic GABAA receptors. This current is a critical regulator of firing and the target of many clinically relevant compounds. Using a combination of patch clamp electrophysiology and photolytic uncaging of RuBi-GABA we show that GABAB receptors are tonically active and enhance extrasynaptic GABAA receptor currents in cerebellar granule cells. This enhancement is not associated with meaningful changes in GABAA receptor potency, mean channel open-time, open probability, or single-channel current. However, there was a significant (~40%) decrease in the number of channels participating in the GABA uncaging current and an increase in receptor desensitization. Furthermore, we find that adenylate cyclase, PKA, CaMKII, and release of Ca2+ from intracellular stores are necessary for modulation of GABAA receptors. Overall, this work reveals crosstalk between postsynaptic GABAA and GABAB receptors and identifies the signaling pathways and mechanisms involved.

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