Approaches to Assess Functional Selectivity in GPCRs: Evaluating G Protein Signaling in an Endogenous Environment

Methods in Molecular Biology - G Protein-Coupled Receptors in Drug Discovery ◽

10.1007/978-1-4939-2914-6_12 ◽

2015 ◽

pp. 177-189 ◽

Author(s):

Laura M. Bohn ◽

Lei Zhou ◽

Jo-Hao Ho

Keyword(s):

G Protein ◽

G Protein Signaling ◽

Protein Signaling ◽

Functional Selectivity

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Faculty Opinions recommendation of Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1025784.305777 ◽

2005 ◽

Author(s):

Rodger Loutzenhiser

Keyword(s):

G Protein ◽

G Protein Signaling ◽

Protein Signaling ◽

Functional Selectivity ◽

Protease Activated Receptor 1

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Functional Selectivity of G Protein Signaling by Agonist Peptides and Thrombin for the Protease-activated Receptor-1

Journal of Biological Chemistry ◽

10.1074/jbc.m414090200 ◽

2005 ◽

Vol 280 (26) ◽

pp. 25048-25059 ◽

Author(s):

Joseph N. McLaughlin ◽

Lixin Shen ◽

Michael Holinstat ◽

Joshua D. Brooks ◽

Emmanuele DiBenedetto ◽

...

Keyword(s):

G Protein ◽

G Protein Signaling ◽

Protein Signaling ◽

Functional Selectivity ◽

Protease Activated Receptor 1

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Regulator of G-Protein Signaling 2

10.32388/nphv4n ◽

2020 ◽

Author(s):

Keyword(s):

G Protein ◽

G Protein Signaling ◽

Protein Signaling

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Faculty Opinions recommendation of Mutation of the regulator of G protein signaling Crg1 increases virulence in Cryptococcus neoformans.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1023154.264841 ◽

2005 ◽

Author(s):

Joseph Heitman

Keyword(s):

Cryptococcus Neoformans ◽

G Protein ◽

G Protein Signaling ◽

Protein Signaling

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Faculty Opinions recommendation of Signaling by a non-dissociated complex of G protein βγ and α subunits stimulated by a receptor-independent activator of G protein signaling, AGS8.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1083787.536710 ◽

2007 ◽

Author(s):

Carmen Dessauer

Keyword(s):

G Protein ◽

G Protein Signaling ◽

Protein Signaling ◽

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Faculty Opinions recommendation of Heterotrimeric G protein signaling functions with dynein to promote spindle positioning in C. elegans.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1092303.546718 ◽

2007 ◽

Author(s):

Bob Goldstein

Keyword(s):

G Protein ◽

G Protein Signaling ◽

Protein Signaling ◽

Heterotrimeric G Protein ◽

Spindle Positioning ◽

C Elegans ◽

Heterotrimeric G Protein Signaling

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Faculty Opinions recommendation of Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1098073.553501 ◽

2007 ◽

Author(s):

Thomas Wynn

Keyword(s):

G Protein ◽

Immunoglobulin E ◽

G Protein Signaling ◽

Protein Signaling

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Faculty Opinions recommendation of Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.3767956.3494054 ◽

2010 ◽

Author(s):

Stephen Schwartz

Keyword(s):

G Protein ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

G Protein Signaling ◽

Signaling Proteins ◽

Protein Signaling

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Faculty Opinions recommendation of Regulator of G-protein signaling-5 inhibits bronchial smooth muscle contraction in severe asthma.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.716947860.792352830 ◽

2012 ◽

Author(s):

YS Prakash ◽

Sathish Venkatachalem

Keyword(s):

Smooth Muscle ◽

Muscle Contraction ◽

G Protein ◽

Severe Asthma ◽

Smooth Muscle Contraction ◽

G Protein Signaling ◽

Protein Signaling ◽

Bronchial Smooth Muscle

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Faculty Opinions recommendation of Roles for regulator of G protein signaling proteins in synaptic signaling and plasticity.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726009695.793567588 ◽

2019 ◽

Author(s):

Michael Andresen

Keyword(s):

G Protein ◽

G Protein Signaling ◽

Signaling Proteins ◽

Protein Signaling ◽

Synaptic Signaling

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