The Microbead Occlusion Model of Ocular Hypertension in Mice

2017 ◽  
pp. 23-39 ◽  
Author(s):  
David J. Calkins ◽  
Wendi S. Lambert ◽  
Cathryn R. Formichella ◽  
William M. McLaughlin ◽  
Rebecca M. Sappington
Keyword(s):  
Ocular Hypertension ◽  
Occlusion Model

scholarly journals A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice

10.3791/53731 ◽  
2016 ◽  
Author(s):  
Yoko A. Ito ◽  
Nicolas Belforte ◽  
Jorge L. Cueva Vargas ◽  
Adriana Di Polo
Keyword(s):  
Ocular Hypertension ◽  
Occlusion Model ◽  
Magnetic Microbead

scholarly journals The Microbead Occlusion Model: A Paradigm for Induced Ocular Hypertension in Rats and Mice

2010 ◽  
Vol 51 (1) ◽  
pp. 207 ◽  
Author(s):  
Rebecca M. Sappington ◽  
Brian J. Carlson ◽  
Samuel D. Crish ◽  
David J. Calkins
Keyword(s):  
Ocular Hypertension ◽  
Occlusion Model ◽  
Rats And Mice

IOP Lowering Effects of Ocimum basilicum Seed Extract in Two Rabbit Models of Ocular Hypertension

2019 ◽  
Vol 4 (1) ◽  
pp. 39
Author(s):  
Renu Agarwal ◽  
SK Gupta ◽  
Sushma Srivastava ◽  
Rohit Saxena
Keyword(s):  
Ocular Hypertension ◽  
Antioxidant Properties ◽  
Ocimum Basilicum ◽  
Seed Extract ◽  
Water Loading ◽  
Antiglaucoma Medication ◽  
Lowering Effect ◽  
Significant Difference ◽  
The Mean ◽  
And Control

Introduction: Ocimum basilicum (OB), a herb known for its antihypertensive, anticholinesterase and antioxidant properties was investigated for possible intraocular pressure (IOP) lowering effects in rabbits with ocular hypertension (OHT). Methods: The IOP lowering effect of a single drop of OB extract (OBE) was evaluated in oculonormotensive rabbits using three concentrations (0.25, 0.5 and 1% w/v). The concentration showing maximum IOP reduction was further evaluated in rabbits with water-loading and steroid-induced OHT. Results: IOP lowering effect of OBE 0.5% in oculonormotensive rabbit eyes was significantly greater compared to OBE 0.25% (p<0.05) but was comparable (p>0.05) to OBE 1%. Therefore, 0.5% concentration was selected for further evaluation. Pretreatment with OBE (0.5%) caused significantly lower increase in IOP after water loading amounting to 23.39% above baseline as compared to 54.00% in control eye, 15 minutes post water loading. At 60 minutes, post water loading, mean IOP rise was 95.12% and 63.58% in control and test eyes, respectively. Significant difference between the mean IOP of two eyes persisted during the 2nd hr. In rabbits with steroid induced OHT, OBE 0.5% produced a mean IOP reduction of 24.73% at the end of first hr and the mean peak IOP reduction of 31.63% was observed at the end of 2 hr. A significant difference between the IOP of test and control eyes persisted from 1 to 6 hr. Conclusions: Ocimum basilicum seed extract showed significant IOP lowering effect in rabbits with water loading and steroid induced OHT, however, its utility as an effective antiglaucoma medication needs further investigations.

Management of patients with ocular hypertension on the background of edematous exophthalmos

2020 ◽  
pp. 298-299
Author(s):  
G.V. Bratko ◽  
◽  
V.I. Bratko ◽  
A.V. Kulakov ◽  
V.V. Chernykh ◽  
...  
Keyword(s):  
Ocular Hypertension

A case report of uveitis with ocular hypertension

2019 ◽  
Vol 83 (6) ◽  
pp. 70-75
Author(s):  
N. Konovalova ◽  
◽  
V. Savko ◽  
N. Khramenko ◽  
O. Guzun ◽  
...  
Keyword(s):  
Case Report ◽  
Ocular Hypertension
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