Generation of High-Affinity Molecularly Imprinted Nanoparticles for Protein Recognition via a Solid-Phase Synthesis Protocol

2019 ◽  
pp. 183-194
Author(s):  
Francesco Canfarotta ◽  
Sergey A. Piletsky ◽  
Nicholas W. Turner
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Protein Recognition ◽  
Molecularly Imprinted ◽  
Phase Synthesis ◽  
High Affinity ◽  
Molecularly Imprinted Nanoparticles ◽  
Synthesis Protocol

Solid-phase synthesis of molecularly imprinted nanoparticles for protein recognition

2013 ◽  
Vol 49 (60) ◽  
pp. 6746 ◽  
Author(s):  
Serena Ambrosini ◽  
Selim Beyazit ◽  
Karsten Haupt ◽  
Bernadette Tse Sum Bui
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Protein Recognition ◽  
Molecularly Imprinted ◽  
Phase Synthesis ◽  
Molecularly Imprinted Nanoparticles

Solid-phase synthesis of molecularly imprinted nanoparticles

2016 ◽  
Vol 11 (3) ◽  
pp. 443-455 ◽  
Author(s):  
Francesco Canfarotta ◽  
Alessandro Poma ◽  
Antonio Guerreiro ◽  
Sergey Piletsky
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Molecularly Imprinted ◽  
Phase Synthesis ◽  
Molecularly Imprinted Nanoparticles

scholarly journals Thermistors coated with molecularly imprinted nanoparticles for the electrical detection of peptides and proteins

The Analyst ◽  
2020 ◽  
Vol 145 (16) ◽  
pp. 5419-5424 ◽  
Author(s):  
K. Betlem ◽  
F. Canfarotta ◽  
R. Raumbault ◽  
C. E. Banks ◽  
K. Eersels ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Dip Coating ◽  
Electrical Detection ◽  
Molecularly Imprinted ◽  
Phase Synthesis ◽  
Molecularly Imprinted Nanoparticles

In this communication, molecularly imprinted nanoparticles (nanoMIPs) that are produced by solid-phase synthesis are functionalised onto thermistors via dip-coating.

Synthesis and Screening of A DNA-Encoded Library of Non-Peptidic Macrocycles

2020 ◽  
Author(s):  
Eric Koesema ◽  
Animesh Roy ◽  
Nicholas G. Paciaroni ◽  
Thomas Kodadek
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Cell Permeability ◽  
Phase Synthesis ◽  
Protein Ligands ◽  
High Affinity ◽  
Scaffold Diversity

There is considerable interest in the development of libraries of non-peptidic macrocycles as a source of ligands for difficult targets. We report here the solid-phase synthesis of a DNA-encoded library of several hundred thousand thioether-linked macrocycles. The library was designed to be highly diverse with respect to backbone scaffold diversity and to minimize the number of amide N-H bonds, which compromise cell permeability. The utility of the library as a source of protein ligands is demonstrated through the isolation of compounds that bind streptavidin, a model target, with high affinity.

scholarly journals Solid-phase synthesis of molecularly imprinted polymer nanolabels: Affinity tools for cellular bioimaging of glycans

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Paulina X. Medina Rangel ◽  
Sylvain Laclef ◽  
Jingjing Xu ◽  
Maria Panagiotopoulou ◽  
José Kovensky ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Phase Synthesis

Construction of a 2,6-Difunctionalized 2-Methyl-2H-1-benzopyran Library by Using a Solid-Phase Synthesis Protocol

2005 ◽  
Vol 70 (24) ◽  
pp. 10151-10154 ◽  
Author(s):  
Jong Yeon Hwang ◽  
Hyung-Sub Choi ◽  
Jin-soo Seo ◽  
Hyun Ju La ◽  
Dong-Soo Kim ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Synthesis Protocol

scholarly journals Automatic reactor for solid-phase synthesis of molecularly imprinted polymeric nanoparticles (MIP NPs) in water

RSC Advances ◽  
2014 ◽  
Vol 4 (8) ◽  
pp. 4203-4206 ◽  
Author(s):  
Alessandro Poma ◽  
Antonio Guerreiro ◽  
Sarah Caygill ◽  
Ewa Moczko ◽  
Sergey Piletsky
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Polymeric Nanoparticles ◽  
Molecularly Imprinted ◽  
Phase Synthesis ◽  
Automatic Reactor
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