polymeric nanoparticles
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2022 ◽  
Vol 19 ◽  
Diaa Al-Domi ◽  
Ayat Bozeya ◽  
Mohamed Al-Fandi

Aim: To develop a new nano-delivery system for insulin buccal administration. Background: Biodegradable polymeric nanoparticles (PNPs) had viewed countless breakthroughs in drug delivery systems. The main objective of PNPs application in delivering and carrying different promising drugs is to make sure that the drugs being delivered to their action sites. As a result maximizing the desired effect and overcoming their limitations and drawbacks. Objectives: The main goals of this study were to produce an insulin consumable nano-delivery system for buccal administration and enhance the mucoadhesive effect in sustaining insulin release. Methods: Water in oil in water (W-O-W) microemulsion solvent evaporation technique was used for the preparation of nanoparticles consisting from positively charged poly (D, L-lactide-co-glycolide) coated with chitosan and loaded with insulin. Later, a consumable buccal film was prepared by the spin coating method and loaded with the previously prepared nanoparticles. Results: The newly prepared nanoparticle was assessed in terms of size, charge and surface morphology using a Scanning Electron Microscope (SEM), zeta potential, Atomic Force Microscope (AFM), and Fourier Transform Infra-red (FTIR) spectroscopy. An in-vitro investigation of the insulin release, from nanoparticles and buccal film, demonstrated controlled as well as sustained delivery over 6 hrs. The cumulative insulin release decreased to about (28.9%) with buccal film in comparing with the nanoparticle (50 %). Conclusion: The buccal film added another barrier for insulin release. Therefore, the release was sustained.

2022 ◽  
Vol 20 (1) ◽  
Jin Wang ◽  
Di Wang ◽  
Moupan Cen ◽  
Danni Jing ◽  
Jiali Bei ◽  

Abstract Background Cancer is the most serious world's health problems on the global level and various strategies have been developed for cancer therapy. Pillar[5]arene-based supramolecular therapeutic nano-platform (SP/GOx NPs) was constructed successfully via orthogonal dynamic covalent bonds and intermolecular H-bonds with the assistance of glucose oxidase (GOx) and exhibited efficient targeted/synergistic chemo-chemodynamic cancer therapy. Methods The morphology of SP/GOx NPs was characterized by DLS, TEM, SEM and EDS mapping. The cancer therapy efficinecy was investigated both in vivo and in vitro. Results SP/GOx NPs can load drug molecules (Dox) and modify target molecule (FA-Py) on its surface conveniently. When the resultant FA-Py/SP/GOx/Dox NPs enters blood circulation, FA-Py will target it to cancer cells efficiently, where GOx can catalyst the overexpressed glucose to generate H2O2. Subsequently, the generated H2O2 in cancer cells catalyzed by ferrocene unit to form •OH, which can kill cancer cells. Furthermore, the loaded Dox molecules released under acid microenvironment, which can further achieve chemo-therapy. Conclusion All the experiments showed that the excellent antitumor performance of FA-Py/SP/GOx/Dox NPs, which provided an new method for pillar[5]arene-based supramolecular polymer for biomedical applications. Graphical Abstract

Joo Young An ◽  
Chaejin Kim ◽  
Na Rae Park ◽  
Han Soo Jung ◽  
Tae‐sung Koo ◽  

Nadia Andrade Aleixo ◽  
Pietra Stefany da Silva Gomes ◽  
Patrícia Bento da Silva ◽  
Mariana Rillo Sato ◽  
Débora Leite Campos ◽  

Guangyi Hou ◽  
Sai Li ◽  
Jun Liu ◽  
Yun-Xuan Weng ◽  
Liqun Zhang

Introducing polymer nanoparticles into polymer matrices is an interesting topic, and the robustness of polymeric nanoparticles is very crucial for the properties of polymer nanocomposites (PNCs). In this study, by...

Talanta ◽  
2022 ◽  
Vol 236 ◽  
pp. 122891
Xiaoliang Yang ◽  
Huan Liu ◽  
Yuting Ji ◽  
Sheng Xu ◽  
Chunmiao Xia ◽  

2022 ◽  
Vol 24 (1) ◽  
Letícia Emiliano Charelli ◽  
Gabriela Calidone de Mattos ◽  
Ariane de Jesus Sousa-Batista ◽  
José Carlos Pinto ◽  
Tiago Albertini Balbino

2022 ◽  
pp. 87-117
Valéria Maria de Oliveira Cardoso ◽  
Leonardo Miziara Barboza Ferreira ◽  
Edson José Comparetti ◽  
Isabella Sampaio ◽  
Natália Noronha Ferreira ◽  

2022 ◽  
pp. 401-426
Vinita Bharadwaj ◽  
Nimisha Singh ◽  
Suban K. Sahoo

2022 ◽  
pp. 338-362
Israt Jahan

Nanotechnology facilitates exclusive opportunities for investigating and controlling a wide range of biomedical approaches at nano-scale, which could provide a groundbreaking impact on medicine, biology, and other health-related areas. This latest technology offers certain distinctive benefits in different aspects such as nanocarriers of targeted drug delivery system, diagnosis and treatment of cancer, vaccination and immunotherapy, biosensing and imaging for clinical diagnosis. A wide range of nanomaterials with biomedical prominence have already been exploited for drug delivery and cancer therapy comprising, solid lipid nanoparticles, metallic nanoparticles, polymeric nanoparticles, carbon nanotube, nanogel-based compounds, nanocapsules, magnetic nanoparticles, nanofluids, nanowires, liposomes, etc. Therefore, this chapter reviewed the potential use of different nanomaterials for therapeutic applications, especially for drug delivery and cancer diagnosis and therapy by focusing their suitability and biocompatibility for extensive and safer usages.

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