GABAA Receptor α1 Subunit (Gabra1) Knockout Mice: Review and New Results

2009 ◽  
pp. 65-90 ◽  
Author(s):  
Gui-Lan Ye ◽  
Kevin B. Baker ◽  
Sara M. Mason ◽  
Wandong Zhang ◽  
Laura Kirkpatrick ◽  
...  
Keyword(s):  
Gabaa Receptor ◽  
Knockout Mice ◽  
Α1 Subunit

Molecular and Pharmacological Characterization of GABAA Receptor α1 Subunit Knockout Mice

2002 ◽  
Vol 302 (3) ◽  
pp. 1037-1045 ◽  
Author(s):  
J. E. Kralic ◽  
E. R. Korpi ◽  
T. K. O'Buckley ◽  
G. E. Homanics ◽  
A. L. Morrow
Keyword(s):  
Gabaa Receptor ◽  
Knockout Mice ◽  
Pharmacological Characterization ◽  
Α1 Subunit

GABAA Receptor α1 Subunit Knockout Mice: A Novel Model of Essential Tremor

2005 ◽  
pp. 369-375 ◽  
Author(s):  
JESSICA L. OSTERMAN ◽  
JASON E. KRALIC ◽  
TODD K. O'BUCKLEY ◽  
GREGG E. HOMANICS ◽  
A. LESLIE MORROW
Keyword(s):  
Essential Tremor ◽  
Gabaa Receptor ◽  
Knockout Mice ◽  
Novel Model ◽  
Α1 Subunit

GABAA Receptor β3 Subunit Deletion Decreases α2/3 Subunits and IPSC Duration

2003 ◽  
Vol 89 (1) ◽  
pp. 128-134 ◽  
Author(s):  
Epolia Ramadan ◽  
Zhanyan Fu ◽  
Gabriele Losi ◽  
Gregg E. Homanics ◽  
Joseph H. Neale ◽  
...  
Keyword(s):  
Gabaa Receptor ◽  
Cortical Neurons ◽  
Behavioral Deficits ◽  
Inhibitory Postsynaptic Currents ◽  
Postsynaptic Currents ◽  
Surface Staining ◽  
Α1 Subunit

Deletion of the β3 subunit of the GABAA receptor produces severe behavioral deficits and epilepsy. GABAA receptor-mediated miniature inhibitory postsynaptic currents (mIPSCs) in cortical neurons in cultures from β3 −/− mice were significantly faster than those in β3 +/+ mice and were more prolonged by zolpidem. Surface staining revealed that the number of β2/3, α2, and α3 (but not of α1) subunit-expressing neurons and the intensity of subunit clusters were significantly reduced in β3 −/− mice. Transfection of β3 −/− neurons with β3 cDNA restored β2/3, α2, and α3 subunits immunostaining and slowed mIPSCs decay. We show that the deletion of the β3 subunit causes the loss of a subset of GABAA receptors with α2 and α3 subunits while leaving a receptor population containing predominantly α1 subunit with fast spontaneous IPSC decay and increased zolpidem sensitivity.

scholarly journals Decreased viability and absence-like epilepsy in mice lacking or deficient in the GABAA receptor α1 subunit

Epilepsia ◽  
2012 ◽  
Vol 53 (8) ◽  
pp. e161-e165 ◽  
Author(s):  
Fazal M. Arain ◽  
Kelli L. Boyd ◽  
Martin J. Gallagher
Keyword(s):  
Gabaa Receptor ◽  
Α1 Subunit

scholarly journals Expression of GABAA receptor α1 subunit mRNA and protein in rat neocortex following photothrombotic infarction

2008 ◽  
Vol 1210 ◽  
pp. 29-38 ◽  
Author(s):  
Elena A. Kharlamov ◽  
Kathy L. Downey ◽  
Peter I. Jukkola ◽  
Dennis R. Grayson ◽  
Kevin M. Kelly
Keyword(s):  
Gabaa Receptor ◽  
Subunit Mrna ◽  
Rat Neocortex ◽  
Α1 Subunit

Localization of GABAA-receptor α1 subunit mRNA-containing neurons in the lower brainstem of the rat

1990 ◽  
Vol 7 (4) ◽  
pp. 335-345 ◽  
Author(s):  
T. Hironaka ◽  
Y. Morita ◽  
S. Hagihira ◽  
E. Tateno ◽  
H. Kita ◽  
...  
Keyword(s):  
Gabaa Receptor ◽  
Subunit Mrna ◽  
Α1 Subunit
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