Restoring Visual Function After Photoreceptor Degeneration: Ectopic Expression of Photosensitive Proteins in Retinal Neurons

2011 ◽  
pp. 147-164
Author(s):  
Bin Lin ◽  
Richard H. Masland
Keyword(s):  
Visual Function ◽  
Ectopic Expression ◽  
Retinal Neurons ◽  
Photoreceptor Degeneration ◽  
Photosensitive Proteins

scholarly journals Targeting lateral inhibition to improve vision following macular degeneration

2020 ◽  
Author(s):  
M Rizzi ◽  
K Powell ◽  
MR Robinson ◽  
T Matsuki ◽  
J Hoke ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Lateral Inhibition ◽  
Visual Function ◽  
Therapeutic Target ◽  
Age Related Macular Degeneration ◽  
Photoreceptor Degeneration ◽  
Specific Mechanism ◽  
Inhibitory Circuits ◽  
Age Related ◽  
Developed World

AbstractMacular degeneration is the leading cause of blindness in the developed world. Whilst most patients lose sight owing to atrophic changes, no treatments currently exist that improve the vision deficit due to atrophy. Here, we identify loss of lateral inhibition as a specific mechanism by which photoreceptor degeneration reduces visual function beyond the atrophic area. We find that this inhibition is adaptive, and that if modulated can improve visual function, making inhibitory circuits an unexpected therapeutic target for age related macular degeneration and related disorders.

scholarly journals Ectopic Expression of a Microbial-Type Rhodopsin Restores Visual Responses in Mice with Photoreceptor Degeneration

Neuron ◽  
2006 ◽  
Vol 50 (1) ◽  
pp. 23-33 ◽  
Author(s):  
Anding Bi ◽  
Jinjuan Cui ◽  
Yu-Ping Ma ◽  
Elena Olshevskaya ◽  
Mingliang Pu ◽  
...  
Keyword(s):  
Ectopic Expression ◽  
Photoreceptor Degeneration ◽  
Visual Responses

scholarly journals Systemic taurine treatment provides neuroprotection against retinal photoreceptor degeneration and visual function impairments

2019 ◽  
Vol Volume 13 ◽  
pp. 2689-2702 ◽  
Author(s):  
Ye Tao ◽  
Miao He ◽  
Qinghua Yang ◽  
Zhao Ma ◽  
Yingxin Qu ◽  
...  
Keyword(s):  
Visual Function ◽  
Photoreceptor Degeneration ◽  
Retinal Photoreceptor ◽  
Taurine Treatment

scholarly journals Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin

2008 ◽  
Vol 105 (41) ◽  
pp. 16009-16014 ◽  
Author(s):  
B. Lin ◽  
A. Koizumi ◽  
N. Tanaka ◽  
S. Panda ◽  
R. H. Masland
Keyword(s):  
Retinal Degeneration ◽  
Visual Function ◽  
Ectopic Expression

scholarly journals Genetically engineered retina for improved retinal reconstruction after transplantation

2020 ◽  
Author(s):  
Take Matsuyama ◽  
Hung-Ya Tu ◽  
Jianan Sun ◽  
Tomoyo Hashiguchi ◽  
Ryutaro Akiba ◽  
...  
Keyword(s):  
Visual Function ◽  
Photoreceptor Cell ◽  
Cell Layer ◽  
Layer Structure ◽  
Genetically Engineered ◽  
Synaptic Connections ◽  
Visual Recovery ◽  
Retinal Neurons ◽  
Neural Integration ◽  
End Stage

AbstractES/iPS-retinal sheet transplantation, which supplies photoreceptors as well as other retinal cells, has been shown able to restore visual function in mice with end-stage retinal degeneration. Here, by introducing a novel type of genetically engineered ES/iPS-retinal sheet with reduced numbers of secondary retinal neurons but intact photoreceptor cell layer structure, we reinforced the evidence that ES/iPS-retinal sheet transplantation can establish synaptic connections with the host, restore light responsiveness and reduce aberrant RGC spiking. Furthermore, we show that genetically engineered grafts can substantially improve the outcome of the treatment by improving neural integration. We speculate that this leads to reduced spontaneous activity in the host which in turn contributes to a better visual recovery.

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