iPS Cells: New Applications for Metabolic Liver Diseases

2012 ◽  
pp. 85-95
Author(s):  
Tobias Cantz ◽  
Abbas Beh-Pajooh ◽  
Malte Sgodda
Keyword(s):  
Liver Diseases ◽  
Ips Cells ◽  
New Applications ◽  
Metabolic Liver Diseases

New Applications of Oleanolic Acid and its Derivatives as Cardioprotective Agents: A Review of their Therapeutic Perspectives

2019 ◽  
Vol 25 (35) ◽  
pp. 3740-3750 ◽  
Author(s):  
Ning Sun ◽  
Dongli Li ◽  
Xiaoqing Chen ◽  
Panpan Wu ◽  
Yu-Jing Lu ◽  
...  
Keyword(s):  
Oleanolic Acid ◽  
Liver Diseases ◽  
Therapeutic Agent ◽  
Heart Diseases ◽  
Pentacyclic Triterpenoids ◽  
Hepatic Drug ◽  
Approved Drugs ◽  
New Applications ◽  
Functional Mechanisms ◽  
Potent Therapeutic Agent

Oleanolic acid is an analogue of pentacyclic triterpenoids. It has been used as a hepatic drug for over 20 years in China. Currently, there are only five approved drugs derived from pentacyclic triterpenoids, including oleanolic acid (liver diseases), asiaticoside (wound healing), glycyrrhizinate (liver diseases), isoglycyrrhizinate (liver disease) and sodium aescinate (hydrocephalus). To understand more about the bioactivity and functional mechanisms of oleanolic acid, it can be developed as a potent therapeutic agent, in particular, for the prevention and treatment of heart diseases that are the leading cause of death for people worldwide. The primary aim of this mini-review is to summarize the new applications of oleanolic acid and its derivatives as cardioprotective agents reported in recent years and to highlight their therapeutic perspectives in cardiovascular diseases.

scholarly journals Pediatric metabolic liver diseases: Evolving role of liver transplantation

2021 ◽  
Vol 11 (6) ◽  
pp. 161-179
Author(s):  
Jagadeesh Menon ◽  
Mukul Vij ◽  
Deepti Sachan ◽  
Ashwin Rammohan ◽  
Naresh Shanmugam ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Diseases ◽  
Metabolic Liver Diseases

LIVER TRANSPLANTATION FOR METABOLIC LIVER DISEASES

1999 ◽  
Vol 79 (1) ◽  
pp. 153-162 ◽  
Author(s):  
Ajai Khanna ◽  
Ashok Jain ◽  
Bijan Eghtesad ◽  
Jorge Rakela
Keyword(s):  
Liver Transplantation ◽  
Liver Diseases ◽  
Metabolic Liver Diseases

Model for end-stage liver disease (MELD) exception for unusual metabolic liver diseases

2006 ◽  
Vol 12 (S3) ◽  
pp. S124-S127 ◽  
Author(s):  
Sue McDiarmid ◽  
Robert G. Gish ◽  
Simon Horslen ◽  
George V. Mazariegos
Keyword(s):  
Liver Disease ◽  
Liver Diseases ◽  
End Stage Liver Disease ◽  
End Stage ◽  
Metabolic Liver Diseases

Metabolic liver diseases presenting with neonatal cholestasis: at the crossroad between old and new paradigms

2019 ◽  
Vol 178 (4) ◽  
pp. 515-523 ◽  
Author(s):  
Helena Moreira-Silva ◽  
Inês Maio ◽  
Anabela Bandeira ◽  
Esmeralda Gomes-Martins ◽  
Ermelinda Santos-Silva
Keyword(s):  
Liver Diseases ◽  
Neonatal Cholestasis ◽  
Metabolic Liver Diseases

scholarly journals A Challenging Case of Severe Infantile Cholestasis in Alpha-1 Antitrypsin Deficiency

2017 ◽  
Vol 20 (2) ◽  
pp. 176-181 ◽  
Author(s):  
Zahida Khan ◽  
Veena L Venkat ◽  
Kyle A Soltys ◽  
Donna B Stolz ◽  
Sarangarajan Ranganathan
Keyword(s):  
Liver Diseases ◽  
Unusual Case ◽  
Newborn Period ◽  
Pediatric Liver Disease ◽  
Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin Deficiency ◽  
Conjugated Hyperbilirubinemia ◽  
Alpha 1 Antitrypsin ◽  
Infantile Cholestasis ◽  
Metabolic Liver Diseases

Jaundice in the newborn period can be physiologic and is often due to benign causes. Jaundice due to conjugated hyperbilirubinemia extending beyond the second week of life may be an early sign of several cholestatic or metabolic liver diseases, and it requires logical and timely analysis so that specific treatments can be initiated. Alpha-1 antitrypsin deficiency is the most common genetic cause of pediatric liver disease and transplantation, and it must be considered when evaluating cholestatic infants. Here, we present an unusual case of alpha-1 antitrypsin deficiency with severe infantile cholestasis and rapid decompensation in the first 4 months of life, where in-depth but timely diagnosis was crucial for the appropriate intervention to take place.

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