The Blood-Based Glycophorin A (GPA) Human In Vivo Somatic Mutation Assay

2014 ◽  
pp. 223-244 ◽  
Author(s):  
Nicole T. Myers ◽  
Stephen G. Grant
Keyword(s):  
Somatic Mutation ◽  
Glycophorin A ◽  
Mutation Assay

scholarly journals Use of the glycophorin A somatic mutation assay for rapid, unambiguous identification of Fanconi anemia homozygotes regardless ofGPA genotype

2005 ◽  
Vol 135A (1) ◽  
pp. 59-65 ◽  
Author(s):  
Viktoria N. Evdokimova ◽  
Reagan K. McLoughlin ◽  
Sharon L. Wenger ◽  
Stephen G. Grant
Keyword(s):  
Somatic Mutation ◽  
Fanconi Anemia ◽  
Glycophorin A ◽  
Mutation Assay

Diagnosis of Ataxia Telangiectasia with the Glycophorin A Somatic Mutation Assay

1997 ◽  
Vol 1 (4) ◽  
pp. 261-267 ◽  
Author(s):  
STEPHEN G. GRANT ◽  
WENDY REEGER ◽  
SHARON L. WENGER
Keyword(s):  
Somatic Mutation ◽  
Ataxia Telangiectasia ◽  
Glycophorin A ◽  
Mutation Assay

The GPA In Vivo Somatic Mutation Assay

2004 ◽  
pp. 179-196
Author(s):  
Stephen G. Grant
Keyword(s):  
Somatic Mutation ◽  
Mutation Assay

Development and characterization of an in vivo somatic mutation assay

1996 ◽  
Vol 360 (3) ◽  
pp. 202-203
Author(s):  
D.A. Casciano ◽  
A. Aidoo ◽  
R. Heflich ◽  
L. Lyn-Cook ◽  
R. Mittelstaedt ◽  
...  
Keyword(s):  
Somatic Mutation ◽  
Mutation Assay

Biodosimetry of Chernobyl Cleanup Workers from Estonia and Latvia Using the Glycophorin A In Vivo Somatic Cell Mutation Assay

1997 ◽  
Vol 147 (2) ◽  
pp. 215 ◽  
Author(s):  
William L. Bigbee ◽  
Ronald H. Jensen ◽  
Toomas Veidebaum ◽  
Mare Tekkel ◽  
Mati Rahu ◽  
...  
Keyword(s):  
Somatic Cell ◽  
Glycophorin A ◽  
Cell Mutation ◽  
Mutation Assay ◽  
Cleanup Workers

scholarly journals The in vivo Pig-a gene mutation assay is applied to study the genotoxicity of procarbazine hydrochloride in Sprague-Dawley rats

2016 ◽  
Vol 3 (4) ◽  
pp. 167-175 ◽  
Author(s):  
Jiang Pu ◽  
Yuanyuan Deng ◽  
Xiaoyan Tan ◽  
Gaofeng Chen ◽  
Cong Zhu ◽  
...  
Keyword(s):  
Gene Mutation ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Mutation Assay ◽  
Gene Mutation Assay

scholarly journals GENOTOXIC AND CARCINOGENIC STUDIES OF NORGESTREL IN DROSOPHILA MELANOGASTER

2018 ◽  
Vol 11 (10) ◽  
pp. 372
Author(s):  
Abou-eisha A ◽  
Adel E El-din
Keyword(s):  
Somatic Mutation ◽  
Cellular Proliferation ◽  
Research Work ◽  
The Body ◽  
The Other ◽  
Direct Stimulation ◽  
Carcinogenic Activity ◽  
Genetic Examination ◽  
First Time

Objective: The aim of this study was to investigate, for the first time, the possible in vivo genotoxic and carcinogenic activity associated with exposure to norgestrel (NGT) drug through employing the very recently established and adjusted genotoxic and tumorigenic methods in Drosophila melanogaster.Methods: Two in vivo genotoxic test systems were used; one detects the somatic mutation and recombination effects (somatic mutation and recombination test [SMART] wing-spot test) and the other detects the primary DNA damage (the comet test) in the body cells of D. melanogaster. On the other hand, the warts (wts)-based SMART assay is a vital genetic examination in Drosophila used to identify and characterize cancer potential of compounds.Results: Four experimental doses of NGT were used (ranging from 0.24 μM to 16 μM). NGT was found to be non-genotoxic at all tested concentrations even at the highest dose level 16 μM and failed to increase the frequency of tumors in the somatic cells of D. melanogaster.Conclusion: Our results strengthen the hypothesis that steroidal drugs might act through a non-genotoxic carcinogen mechanism where the carcinogenic properties occur by direct stimulation of cellular proliferation through a steroid receptor-mediated mechanism. In addition, the results obtained in this research work may contribute to highlighting the importance of NGT as a potent neuroprotective antioxidant drug.

scholarly journals 521 HUMAN HEMOGLOBIN IN VIVO SOMATIC CELL MUTATION ASSAY

1978 ◽  
Vol 12 ◽  
pp. 450-450
Author(s):  
Richard Doherty ◽  
Elsa Cernichiari
Keyword(s):  
Somatic Cell ◽  
Human Hemoglobin ◽  
Cell Mutation ◽  
Mutation Assay
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