Cerebral Blood Flow Measurement with Oxygen-15 Water Positron Emission Tomography

2020 ◽  
pp. 127-152
Author(s):  
Henryk Barthel ◽  
Vilia Zeisig ◽  
Björn Nitzsche ◽  
Marianne Patt ◽  
Jörg Patt ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Flow Measurement ◽  
Emission Tomography ◽  
Blood Flow Measurement ◽  
Cerebral Blood Flow Measurement ◽  
Positron Emission ◽  
Oxygen 15 Water

scholarly journals Evaluation of [18F]-4-Fluoroantipyrine as a New Blood Flow Tracer for Multiradionuclide Autoradiography

1984 ◽  
Vol 4 (2) ◽  
pp. 259-263 ◽  
Author(s):  
Kazuhiro Sako ◽  
Mirko Diksic ◽  
Amami Kato ◽  
Y. Lucas Yamamoto ◽  
William Feindel
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Flow Measurement ◽  
Emission Tomography ◽  
Blood Flow Measurement ◽  
Local Cerebral Blood Flow ◽  
Positron Emission ◽  
The Brain ◽  
Flow Tracer

This article reports the evaluation of [18F]-4-fluoroantipyrine (FAP) as a quantitative blood flow tracer by comparing blood flow measured with [18F]FAP to that determined simultaneously with [14C]-4-iodoantipyrine (IAP), a standard blood flow tracer, by means of double-tracer autoradiography. The single-pass extraction value ( m), which indicates diffusibility of a tracer, was determined according to the procedure described by Crone. The diffusibility of FAP was essentially the same as that of IAP. The brain–blood partition coefficient for FAP was found to be similar to that for IAP, 0.89 ± 0.01. Values of local cerebral blood flow obtained with FAP agree with those determined with IAP. From these results, we concluded that FAP is indeed as good a blood flow tracer as IAP. Since 18F is a positron-emitting radionuclide, it might be a useful tracer for blood flow measurement by positron emission tomography.

Dynamic renal blood flow measurement by positron emission tomography in patients with CRF

2002 ◽  
Vol 40 (5) ◽  
pp. 947-954 ◽  
Author(s):  
Laurent Juillard ◽  
Marc F. Janier ◽  
Denis Fouque ◽  
Luc Cinotti ◽  
Nora Maakel ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Renal Blood Flow ◽  
Flow Measurement ◽  
Emission Tomography ◽  
Blood Flow Measurement ◽  
Positron Emission

scholarly journals Renal blood flow measurement by positron emission tomography using 15O-labeled water

2000 ◽  
Vol 57 (6) ◽  
pp. 2511-2518 ◽  
Author(s):  
Laurent Juillard ◽  
Marc F. Janier ◽  
Denis Fouque ◽  
Martine Lionnet ◽  
Didier Le Bars ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Renal Blood Flow ◽  
Flow Measurement ◽  
Emission Tomography ◽  
Blood Flow Measurement ◽  
Positron Emission

scholarly journals Effects of Acetazolamide on Cerebral Blood Flow, Blood Volume, and Oxygen Metabolism: A Positron Emission Tomography Study with Healthy Volunteers

2001 ◽  
Vol 21 (12) ◽  
pp. 1472-1479 ◽  
Author(s):  
Hidehiko Okazawa ◽  
Hiroshi Yamauchi ◽  
Kanji Sugimoto ◽  
Hiroshi Toyoda ◽  
Yoshihiko Kishibe ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Metabolic Rate ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Capillary Blood ◽  
Emission Tomography ◽  
Positron Emission ◽  
Capillary Blood Volume

To evaluate changes in cerebral hemodynamics and metabolism induced by acetazolamide in healthy subjects, positron emission tomography studies for measurement of cerebral perfusion and oxygen consumption were performed. Sixteen healthy volunteers underwent positron emission tomography studies with15O-gas and water before and after intravenous administration of acetazolamide. Dynamic positron emission tomography data were acquired after bolus injection of H215O and bolus inhalation of15O2. Cerebral blood flow, metabolic rate of oxygen, and arterial-to-capillary blood volume images were calculated using the three-weighted integral method. The images of cerebral blood volume were calculated using the bolus inhalation technique of C15O. The scans for cerebral blood flow and volume and metabolic rate of oxygen after acetazolamide challenge were performed at 10, 20, and 30 minutes after drug injection. The parametric images obtained under the two conditions at baseline and after acetazolamide administration were compared. The global and regional values for cerebral blood flow and volume and arterial-to-capillary blood volume increased significantly after acetazolamide administration compared with the baseline condition, whereas no difference in metabolic rate of oxygen was observed. Acetazolamide-induced increases in both blood flow and volume in the normal brain occurred as a vasodilatory reaction of functioning vessels. The increase in arterial-to-capillary blood volume made the major contribution to the cerebral blood volume increase, indicating that the raise in cerebral blood flow during the acetazolamide challenge is closely related to arterial-to-capillary vasomotor responsiveness.

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