Considering nowadays growth of electronic data, the necessity of major data centers establishment is also increasing. Such centers may contain data distribution, storing and processing systems, like servers. The equipment generates huge heat energy, so an appropriate microclimate is required in such premises. High capacity air conditioners are used for maintaining of appropriate parameters and assuring normal functioning of these systems. Herein you can find comparison analysis of central and precision air conditioning systems considering two parameters: cost and energy efficiency for the central regions of the Russian Federation. During such comparison analysis the most cost-efficient and ergonomic air conditioning system was revealed for the Data Center Berzarina, Moscow.