Spinal and Bone Tuberculosis

2021 ◽  
pp. 67-84
Author(s):  
Jonathan Bull ◽  
Veronica White
Keyword(s):  
2021 ◽  
Vol 9 (7) ◽  
Author(s):  
Imen Chabchoub ◽  
Raida Ben Salah ◽  
Wien Feki ◽  
Zeineb Mnif ◽  
Zouhir Bahloul
Keyword(s):  

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1416.1-1416
Author(s):  
O. Malyshenko ◽  
M. Koroleva ◽  
M. Letaeva ◽  
J. Averkieva ◽  
T. Raskina

Background:Undifferentiated arthritis (UDA) is an inflammatory arthritis that does not meet the criteria for any rheumatologic disease. Early verification of UDA is currently one of the main goals of modern rheumatology, since a diagnosis established at an early date allows determining a therapeutic strategy. The high social significance of arthritis lies in the predominant lesion of people of working age, the steady progression of the disease, early disability and a reduction in life expectancy.Objectives:To study the gender characteristics of verification of the diagnosis of undifferentiated arthritis.Methods:A retrospective analysis of 74 case histories of patients diagnosed with UDA was carried out. The study group consisted of 26 men and 48 women, mean age 50.6 ± 4.3 years. All patients underwent a comprehensive laboratory and instrumental examination according to the standard of an articular syndrome of unclear genesis.Results:According to the data obtained, the duration of the articular syndrome averaged 2.53 ± 1.2 years. In 29 patients (21.6% of women and 17.6% of men), on average, after 1.72 ± 0.9 years, the diagnosis of NDA was clarified. Taking into account modern diagnostic criteria, the following diseases were verified: rheumatoid arthritis in 13.5% (12.2% in women and 1.3% in men), ankylosing spondylitis in 10.8% (2.7% in women and 8.1% in men). Osteoarthritis, psoriatic arthritis and APS were diagnosed in 5.4%, 1.4% and 1.4% of women, and gouty arthritis, bone tuberculosis and HIV in 4.1%, 1.4% and 1.4% of men respectively. In 60.8% (43.2% in women and 17.6% in men), the etiology of arthritis was not verified.Conclusion:In a third of patients with UDA, diagnosis verification takes about 2 years on average. In more than half of patients, the diagnosis remains the same. According to the data obtained, rheumatoid arthritis was more often verified in women, while ankylosing spondylitis in men, which is consistent with statistical data.Disclosure of Interests:None declared


2021 ◽  
Vol 20 (8) ◽  
pp. 872-872
Author(s):  
M. Friedland

Tuberculous spondylitis in the Orthopedic Department of the Charit Surgical Polyclinic in Berlin, according to the study of Bergmann'a (Arch. F. Orthop. U. Unf-Chir., 1923, XXII), during the time from 1912 to 1922 was established 342 times, which is 23% in relation to all bone-tuberculosis patients.


2018 ◽  
Vol 33 (7) ◽  
pp. 989-996 ◽  
Author(s):  
Gangquan Chen ◽  
Yaling Wu ◽  
Dongping Yu ◽  
Rubing Li ◽  
Wenyuan Luo ◽  
...  

Poor blood circulation makes it difficult for antitubercular drugs to achieve effective bactericidal concentration at tuberculose focus. The residual Mycobacterium tuberculosis around surgical wound would multiply, resulting in nonunion or sinus formation. Carbon nanotubes have strong tissue penetration and can cross many kinds of physiological barriers. Here, we constructed a chitosan/carbon nanotubes nanoparticles to control slow release of isoniazid. Transmission electron microscopy and nanoparticle tracking and analysis results showed that the diameter of chitosan/carbon nanotubes nanoparticles was between 150 and 250 nm. Chitosan/carbon nanotubes nanoparticles significantly prolonged the release time of isoniazid, and the release rate was more uniform, no sudden release was observed. In vitro experiments showed that chitosan/carbon nanotubes nanoparticles did not destroy biological function of isoniazid, but could reduce its cytotoxicity and inflammation. We further constructed animal model of tuberculous ulcer. The results showed that isoniazid/chitosan/carbon nanotubes nanoparticles promoted the healing of tuberculosis ulcer. Compared with isoniazid group and isoniazid/carbon nanotubes group, the area of wounds decreased by 94.6% and 89.8%, respectively. Immunohistochemistry showed that CD3+ and CD4+ T cell number decreased significantly in isoniazid/chitosan/carbon nanotubes group. In conclusion, we constructed a kind of isoniazid/chitosan/carbon nanotubes nanoparticles, which can significantly promote the healing of tuberculosis ulcer. Our study provided an effective way for the treatment of secondary wound healing of bone tuberculosis.


Radiology ◽  
1930 ◽  
Vol 15 (3) ◽  
pp. 374-376
Author(s):  
Malcolm B. Hanson ◽  
I. Fenger
Keyword(s):  

2012 ◽  
Vol 107 (8) ◽  
pp. 1048-1053 ◽  
Author(s):  
Tamás Hajdu ◽  
Erzsébet Fóthi ◽  
Ivett Kovári ◽  
Mónika Merczi ◽  
Attila Molnár ◽  
...  

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