Endothelial Colony-Forming Cells in Pulmonary Arterial Hypertension

2015 ◽  
pp. 183-192
Author(s):  
Kewal Asosingh ◽  
Jonathan Rose ◽  
Serpil Erzurum
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Endothelial Colony Forming Cells ◽  
Pulmonary Arterial

scholarly journals Blood Outgrowth and Proliferation of Endothelial Colony Forming Cells are Related to Markers of Disease Severity in Patients with Pulmonary Arterial Hypertension

2018 ◽  
Vol 19 (12) ◽  
pp. 3763 ◽  
Author(s):  
Josien Smits ◽  
Dimitar Tasev ◽  
Stine Andersen ◽  
Robert Szulcek ◽  
Liza Botros ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Pulmonary Vascular Resistance ◽  
Disease Severity ◽  
Vascular Resistance ◽  
Tube Formation ◽  
Pulmonary Trunk ◽  
Vascular Density ◽  
Endothelial Colony Forming Cells ◽  
Pulmonary Arterial

In pulmonary arterial hypertension (PAH), lung-angioproliferation leads to increased pulmonary vascular resistance, while simultaneous myocardial microvessel loss contributes to right ventricular (RV) failure. Endothelial colony forming cells (ECFC) are highly proliferative, angiogenic cells that may contribute to either pulmonary vascular obstruction or to RV microvascular adaptation. We hypothesize ECFC phenotypes (outgrowth, proliferation, tube formation) are related to markers of disease severity in a prospective cohort-study of 33 PAH and 30 healthy subjects. ECFC were transplanted in pulmonary trunk banded rats with RV failure. The presence of ECFC outgrowth in PAH patients was associated with low RV ejection fraction, low central venous saturation and a shorter time to clinical worsening (5.4 months (0.6–29.2) vs. 36.5 months (7.4–63.4), p = 0.032). Functionally, PAH ECFC had higher proliferative rates compared to control in vitro, although inter-patient variability was high. ECFC proliferation was inversely related to RV end diastolic volume (R2 = 0.39, p = 0.018), but not pulmonary vascular resistance. Tube formation-ability was similar among donors. Normal and highly proliferative PAH ECFC were transplanted in pulmonary trunk banded rats. While no effect on hemodynamic measurements was observed, RV vascular density was restored. In conclusion, we found that ECFC outgrowth associates with high clinical severity in PAH, suggesting recruitment. Transplantation of highly proliferative ECFC restored myocardial vascular density in pulmonary trunk banded rats, while RV functional improvements were not observed.

scholarly journals Pulmonary Artery Endothelium Resident Endothelial Colony-Forming Cells in Pulmonary Arterial Hypertension

2011 ◽  
Vol 1 (4) ◽  
pp. 475-486 ◽  
Author(s):  
Heng T. Duong ◽  
Suzy A. Comhair ◽  
Micheala A. Aldred ◽  
Lori Mavrakis ◽  
Benjamin M. Savasky ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Pulmonary Artery ◽  
Arterial Hypertension ◽  
Endothelial Colony Forming Cells ◽  
Pulmonary Arterial
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