Current Status of Genome Editing in Cardiovascular Medicine

AbstractLarge animals (non-human primates, livestock and dogs) are playing important roles in biomedical research, and large livestock animals serve as important sources of meat and milk. The recently developed programmable DNA nucleases have revolutionized the generation of gene-modified large animals that are used for biological and biomedical research. In this review, we briefly introduce the recent advances in nuclease-meditated gene editing tools, and we outline these editing tools’ applications in human disease modeling, regenerative medicine and agriculture. Additionally, we provide perspectives regarding the challenges and prospects of the new genome editing technology.

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Genome editing for potato (Solanum tuberosum L.)–current status and future prospects

IOP Conference Series Earth and Environmental Science ◽

10.1088/1755-1315/482/1/012004 ◽

2020 ◽

Vol 482 ◽

pp. 012004

Author(s):

D S Douches ◽

S S Nadakuduti ◽

F Enciso ◽

N M Carpintero

Keyword(s):

Solanum Tuberosum ◽

Genome Editing ◽

Solanum Tuberosum L ◽

Current Status ◽

Future Prospects

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Distal protection in cardiovascular medicine: Current status

American Heart Journal ◽

10.1016/j.ahj.2005.12.017 ◽

2006 ◽

Vol 152 (2) ◽

pp. 207-216 ◽

Cited By ~ 5

Author(s):

Onn Akbar Ali ◽

Ravinay Bhindi ◽

Aisling C. McMahon ◽

David Brieger ◽

Leonard Kritharides ◽

...

Keyword(s):

Current Status ◽

Cardiovascular Medicine ◽

Distal Protection

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Trait stacking in modern agriculture: application of genome editing tools

Emerging Topics in Life Sciences ◽

10.1042/etls20170012 ◽

2017 ◽

Vol 1 (2) ◽

pp. 151-160

Author(s):

Sandeep Kumar ◽

Wei Chen ◽

Stephen Novak

Keyword(s):

Genome Editing ◽

Complex Traits ◽

Crop Yields ◽

Agronomic Traits ◽

Single Gene ◽

Genetic Material ◽

Crop Productivity ◽

Current Status ◽

Transgenic Technology ◽

Modern Agriculture

Advances in plant transgenic technology in the 20th century overcame the major hurdle for transfer of genetic material between species. This not only enabled fundamental insights into plant biology, but also revolutionized commercial agriculture. Adoption of transgenic plants in industrial agriculture has reduced pesticide application, while bringing significant increase in crop yields and farmers' profits. The progress made in transgenic technology over the last three decades paved the way mainly for simple single-gene insect and herbicide tolerance (HT) trait products. Modern agriculture demands stacking and pyramiding of complex traits that provide broad-spectrum insect and HT with other agronomic traits. In addition, more recent developments in genome editing provide unique opportunities to create precise on-demand genome modifications to enhance crop productivity. The major challenge for the plant biotech industry therefore remains to combine multiple forms of traits needed to create commercially viable stacked product. This review provides a historical perspective of conventional breeding stacks, current status of molecular stacks and future developments needed to enable genome-editing technology for trait stacking.

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