scholarly journals Bifunctional Recombinant Protein Agent Based on Pseudomonas Exotoxin A Fragment for Targeted Therapy of HER2-Positive Tumors

2017 ◽  
pp. 563-572
Author(s):  
S. M. Deyev ◽  
O. M. Kutova ◽  
E. N. Lebedenko ◽  
G. M. Proshkina ◽  
A. A. Schulga ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Recombinant Protein ◽  
Exotoxin A ◽  
Her2 Positive ◽  
Pseudomonas Exotoxin ◽  
Agent Based ◽  
Pseudomonas Exotoxin A

An EGF-pseudomonas exotoxin A recombinant protein with a deletion in toxin binding domain specifically kills EGF receptor bearing cells

1993 ◽  
Vol 6 (4) ◽  
pp. 433-440 ◽  
Author(s):  
Chi-Hon Lee ◽  
E-Ching Lee ◽  
Shih-Tzer Tsai ◽  
Hsing-Jien Kung ◽  
Yin-Chang Liu ◽  
...  
Keyword(s):  
Recombinant Protein ◽  
Egf Receptor ◽  
Binding Domain ◽  
Exotoxin A ◽  
Pseudomonas Exotoxin ◽  
Pseudomonas Exotoxin A ◽  
Toxin Binding

scholarly journals Pseudomonas exotoxin A. Membrane binding, insertion, and traversal.

1986 ◽  
Vol 261 (24) ◽  
pp. 11404-11408 ◽  
Author(s):  
Z T Farahbakhsh ◽  
R L Baldwin ◽  
B J Wisnieski
Keyword(s):  
Membrane Binding ◽  
Exotoxin A ◽  
Pseudomonas Exotoxin ◽  
Pseudomonas Exotoxin A

scholarly journals Recombinant Immunotoxin 4D5scFv-PE40 for Targeted Therapy of HER2-Positive Tumors

Acta Naturae ◽  
2015 ◽  
Vol 7 (4) ◽  
pp. 93-96 ◽  
Author(s):  
E. A. Sokolova ◽  
O. A. Stremovskiy ◽  
T. A. Zdobnova ◽  
I. V. Balalaeva ◽  
S. M. Deyev
Keyword(s):  
Targeted Therapy ◽  
Tumor Marker ◽  
Cancer Cells ◽  
Therapeutic Index ◽  
Molecular Profile ◽  
Her2 Positive ◽  
Pseudomonas Exotoxin A ◽  
Recombinant Immunotoxin ◽  
Long Run

Recombinant immunotoxins are extremely promising agents for the targeted therapy of tumors with a certain molecular profile. In this work, we studied the properties of a new recombinant HER2-specific immunotoxin composed of the scFv antibody and a fragment of Pseudomonas exotoxin A (4D5scFv-PE40). High affinity of the immunotoxin for the HER2 tumor marker, its selective cytotoxicity against HER2-overexpressing cells, and its storage stability were demonstrated. The 50% inhibitory concentration (IC50) of the 4D5scFv-PE40 immunotoxin for HER2-overexpressing cancer cells was 2.5-3 orders of magnitude lower compared to that for CHO cells not expressing this tumor marker and was 2.5-3 orders of magnitude lower than IC50 of free PE40 for HER2-overexpressing cancer cells. These findings provide a basis for expecting in the long run high therapeutic index values of the 4D5scFv-PE40 immunotoxin for its use in vivo.

Recombinant chimeric vaccine composed of PRRSV antigens and truncated Pseudomonas exotoxin A (PE-K13)

2013 ◽  
Vol 95 (2) ◽  
pp. 742-751 ◽  
Author(s):  
Hsin-Ping Yang ◽  
Tsan-Chih Wang ◽  
Shiou-Jen Wang ◽  
Shih-Ping Chen ◽  
Eva Wu ◽  
...  
Keyword(s):  
Exotoxin A ◽  
Pseudomonas Exotoxin ◽  
Pseudomonas Exotoxin A ◽  
Chimeric Vaccine
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