Chronic Kidney Disease: Global Burden and Perspectives for Africa

Author(s):  
Faical Jarraya
The Lancet ◽  
2020 ◽  
Vol 395 (10225) ◽  
pp. 709-733 ◽  
Author(s):  
Boris Bikbov ◽  
Caroline A Purcell ◽  
Andrew S Levey ◽  
Mari Smith ◽  
Amir Abdoli ◽  
...  

2020 ◽  
Vol 5 (3) ◽  
pp. e002063 ◽  
Author(s):  
Benjamin Bowe ◽  
Elena Artimovich ◽  
Yan Xie ◽  
Yan Yan ◽  
Miao Cai ◽  
...  

IntroductionWe aimed to integrate all available epidemiological evidence to characterise an exposure–response model of ambient fine particulate matter (PM2.5) and the risk of chronic kidney disease (CKD) across the spectrum of PM2.5 concentrations experienced by humans. We then estimated the global and national burden of CKD attributable to PM2.5.MethodsWe collected data from prior studies on the association of PM2.5 with CKD and used an integrative meta-regression approach to build non-linear exposure–response models of the risk of CKD associated with PM2.5 exposure. We then estimated the 2017 global and national incidence, prevalence, disability-adjusted life-years (DALYs) and deaths due to CKD attributable to PM2.5 in 194 countries and territories. Burden estimates were generated by linkage of risk estimates to Global Burden of Disease study datasets.ResultsThe exposure–response function exhibited evidence of an increase in risk with increasing PM2.5 concentrations, where the rate of risk increase gradually attenuated at higher PM2.5 concentrations. Globally, in 2017, there were 3 284 358.2 (95% UI 2 800 710.5 to 3 747 046.1) incident and 122 409 460.2 (108 142 312.2 to 136 424 137.9) prevalent cases of CKD attributable to PM2.5, and 6 593 134.6 (5 705 180.4 to 7 479 818.4) DALYs and 211 019.2 (184 292.5 to 236 520.4) deaths due to CKD attributable to PM2.5. The burden was disproportionately borne by low income and lower middle income countries and exhibited substantial geographic variability, even among countries with similar levels of sociodemographic development. Globally, 72.8% of prevalent cases of CKD attributable to PM2.5 and 74.2% of DALYs due to CKD attributable to PM2.5 were due to concentrations above 10 µg/m3, the WHO air quality guidelines.ConclusionThe global burden of CKD attributable to PM2.5 is substantial, varies by geography and is disproportionally borne by disadvantaged countries. Most of the burden is associated with PM2.5 levels above the WHO guidelines, suggesting that achieving those targets may yield reduction in CKD burden.


2015 ◽  
Vol 33 ◽  
pp. e3
Author(s):  
Katherine T. Mills ◽  
Yu Xu ◽  
Weidong Zhang ◽  
Joshua D. Bundy ◽  
Chung-Shiuan Chen ◽  
...  

2019 ◽  
Vol 169 ◽  
pp. 72-78 ◽  
Author(s):  
Yu Zang ◽  
Brecht Devleesschauwer ◽  
P. Michael Bolger ◽  
Emily Goodman ◽  
Herman J. Gibb

2017 ◽  
Vol 20 (suppl 1) ◽  
pp. 90-101 ◽  
Author(s):  
Bruce Bartholow Duncan ◽  
Elisabeth Barboza França ◽  
Valéria Maria de Azeredo Passos ◽  
Ewerton Cousin ◽  
Lenice Harumi Ishitani ◽  
...  

ABSTRACT: Introduction and objective: The global burden of disease (GBD) 2015 project, extends GBD analyses to include Brazilian federative units separately. We take advantage of GBD methodological advances to describe the current burden of diabetes and hyperglycemia in Brazil. Methods: Using standard GBD 2015 methods, we analyzed the burden of diabetes, chronic kidney disease due to diabetes and high fasting plasma glucose in Brazil and its states. Results: The age-standardized rate of disability-adjusted life years (DALYs) which was lost to high fasting plasma glucose, a category which encompasses burdens of diabetes and of lesser hyperglycemia, were 2448.85 (95% UI 2165.96-2778.69) /100000 for males, and 1863.90 (95% UI 1648.18-2123.47) /100000 for females in 2015. This rate was more than twice as great in states with highest burden, these being overwhelmingly in the northeast and north, compared with those with lowest rates. The rate of crude DALYs for high fasting plasma glucose, increased by 35% since 1990, while DALYs due to all non-communicable diseases increased only by 12.7%, and DALYs from all causes declined by 20.5%. Discussion: The worldwide pandemic of diabetes and hyperglycemia now causes a major and growing disease burden in Brazil, especially in states with greater poverty and a lesser educational level. Conclusion: Diabetes and chronic kidney disease due to diabetes, as well as high fasting plasma glucose in general, currently constitute a major and growing public health problem in Brazil. Actions to date for their prevention and control have been slow considering the magnitude of this burden.


2015 ◽  
Vol 88 (5) ◽  
pp. 950-957 ◽  
Author(s):  
Katherine T. Mills ◽  
Yu Xu ◽  
Weidong Zhang ◽  
Joshua D. Bundy ◽  
Chung-Shiuan Chen ◽  
...  

2016 ◽  
Vol 13 (2) ◽  
pp. 104-114 ◽  
Author(s):  
Richard J. Glassock ◽  
David G. Warnock ◽  
Pierre Delanaye

The Lancet ◽  
2020 ◽  
Vol 395 (10225) ◽  
pp. 662-664 ◽  
Author(s):  
Paul Cockwell ◽  
Lori-Ann Fisher

Sign in / Sign up

Export Citation Format

Share Document