scholarly journals The Role of the Sodium-Taurocholate Cotransporting Polypeptide (NTCP) and of the Bile Salt Export Pump (BSEP) in Physiology and Pathophysiology of Bile Formation

2010 ◽  
pp. 205-259 ◽  
Author(s):  
Bruno Stieger
Keyword(s):  
Bile Salt ◽  
Sodium Taurocholate ◽  
Bile Salt Export Pump ◽  
Bile Formation

The Role of the Sodium-taurocholate Co-transporting Polypeptide (NTCP) and Bile Salt Export Pump (BSEP) in Related Liver Disease

2019 ◽  
Vol 20 (5) ◽  
pp. 377-389 ◽  
Author(s):  
Xiaoyang Lu ◽  
Lin Liu ◽  
Wenya Shan ◽  
Limin Kong ◽  
Na Chen ◽  
...  
Keyword(s):  
Liver Disease ◽  
Structure Function ◽  
Bile Salt ◽  
Drug Targets ◽  
Enterohepatic Circulation ◽  
Sodium Taurocholate ◽  
Bile Salt Export Pump ◽  
Bile Acid Transporters ◽  
Function Relationship ◽  
Related Liver Disease

Background:Sodium Taurocholate Co-transporting Polypeptide (NTCP) and Bile Salt Export Pump (BSEP) play significant roles as membrane transporters because of their presence in the enterohepatic circulation of bile salts. They have emerged as promising drug targets in related liver disease.Methods:We reviewed the literature published over the last 20 years with a focus on NTCP and BSEP.Results:This review summarizes the current perception about structure, function, genetic variation, and regulation of NTCP and BSEP, highlights the effects of their defects in some hepatic disorders, and discusses the application prospect of new transcriptional activators in liver diseases.Conclusion:NTCP and BSEP are important proteins for transportation and homeostasis maintenance of bile acids. Further research is needed to develop new models for determining the structure-function relationship of bile acid transporters and screening for substrates and inhibitors, as well as to gain more information about the regulatory genetic mechanisms involved in the processes of liver injury.

Role of chemical structures and the 1331T>C bile salt export pump polymorphism in idiosyncratic drug-induced liver injury

2013 ◽  
Vol 33 (9) ◽  
pp. 1378-1385 ◽  
Author(s):  
Eugenia Ulzurrun ◽  
Camilla Stephens ◽  
Esperanza Crespo ◽  
Francisco Ruiz-Cabello ◽  
Julia Ruiz-Nuñez ◽  
...  
Keyword(s):  
Liver Injury ◽  
Bile Salt ◽  
Bile Salt Export Pump ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Chemical Structures

scholarly journals Role of polymorphic bile salt export pump (BSEP, ABCB11) transporters in anti-tuberculosis drug-induced liver injury in a Chinese cohort

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Ru Chen ◽  
Jing Wang ◽  
Shaowen Tang ◽  
Yuan Zhang ◽  
Xiaozhen Lv ◽  
...  
Keyword(s):  
Liver Injury ◽  
Bile Salt ◽  
Bile Salt Export Pump ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Chinese Cohort

Pharmacological and physiological doses of insulin and determinants of bile flow in dogs

1983 ◽  
Vol 245 (1) ◽  
pp. G157-G163
Author(s):  
C. A. Garberoglio ◽  
H. M. Richter ◽  
A. Henarejos ◽  
A. R. Moossa ◽  
A. L. Baker
Keyword(s):  
Portal Vein ◽  
Bile Salt ◽  
Bile Flow ◽  
Plasma Insulin ◽  
Sodium Taurocholate ◽  
Bile Secretion

The role of insulin in control of bile secretion is uncertain. To study the mechanism of choleresis produced by large doses of insulin, bile was collected through modified Thomas cannulas from dogs anesthetized with pentobarbital. Animals received pipenzolate methylbromide, sodium taurocholate, and [14C]erythritol. After bile flow had stabilized three animals received infusions of insulin at 2, 4, 13, 26, 35, and 70 mU . kg-1 . min-1 for 40 min each. Bile and [14C]erythritol clearance increased (P less than 0.005), but bile salt output remained constant, suggesting that the choleresis was mainly due to enhanced bile salt-independent canalicular flow. Plasma insulin and glucagon levels also rose when insulin was infused. To exclude the possible effects of glucagon three additional animals received somatostatin (800 ng . kg-1 . min-1) along with infusions of insulin. Bile flow and [14C]erythritol clearance again increased significantly, but glucagon levels remained low, suggesting that the effects on bile flow were due to insulin alone. To determine whether physiological doses of insulin altered bile flow dogs were anesthetized with pentobarbital and received pipenzolate methylbromide, taurocholate, [14C]erythritol, and somatostatin (800 ng . kg-1 . min-1). Insulin (0.2 and 0.8 mU . kg-1 . min-1) was infused through the portal vein for 1 h each. Bile flow and [14C]erythritol clearance increased with insulin (0.8 mU . kg-1 . min-1; P less than 0.02), suggesting that the choleresis may have been due to bile salt-independent canalicular flow. Plasma insulin rose to physiological postprandial levels. These studies demonstrate that pharmacological and physiological levels of insulin administered to dogs produce a significant choleresis. Thus insulin may play an important role in the regulation of bile secretion.

scholarly journals Compensatory role of P-glycoproteins in knockout mice lacking the bile salt export pump

Hepatology ◽  
2009 ◽  
Vol 50 (3) ◽  
pp. 948-956 ◽  
Author(s):  
Renxue Wang ◽  
Huey-Ling Chen ◽  
Lin Liu ◽  
Jonathan A. Sheps ◽  
M. James Phillips ◽  
...  
Keyword(s):  
Bile Salt ◽  
Knockout Mice ◽  
Bile Salt Export Pump
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