Intralaminar Nuclei in Pain

Neurophysiological studies of electrical responses of single cells at various levels of the nervous system to noxious and non-noxious stimulation may give clues regarding acupuncture analgesia. Many cells slow convergent properties receiving input from both low and high threshold cutaneous and peripheral nerve stimulation. Often the former may inhibit the latter. Our studies illustrate three examples fo inhibition mechanisms which may play a role in attenuation of noxiously induced impulses, especially the prolonger discharge. Discussed briefly are other suggested CNS mechanisms that may be involved in processing and attenuating noxious information, including those in brainstem and intralaminar nuclei.

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Direct projections from thalamic intralaminar nuclei to extra-striate visual cortex in the cat traced with Horseradish peroxidase

Experimental Brain Research ◽

10.1007/bf00237091 ◽

1977 ◽

Vol 28-28 (1-2) ◽

Cited By ~ 11

Author(s):

H. Kennedy ◽

C. Baleydier

Keyword(s):

Visual Cortex ◽

Horseradish Peroxidase ◽

Intralaminar Nuclei

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Functional relations between thalamic intralaminar nuclei and caudate nuclei during motor program formation

Bulletin of Experimental Biology and Medicine ◽

10.1007/bf01179116 ◽

1983 ◽

Vol 95 (2) ◽

pp. 161-163 ◽

Cited By ~ 2

Author(s):

N. S. Popova ◽

O. S. Adrianov

Keyword(s):

Motor Program ◽

Caudate Nuclei ◽

Intralaminar Nuclei ◽

Functional Relations

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Termination of thalamic intralaminar nuclei afferents in visual cortex of squirrel monkey

Visual Neuroscience ◽

10.1017/s0952523800000195 ◽

1990 ◽

Vol 5 (2) ◽

pp. 151-154 ◽

Cited By ~ 14

Author(s):

Lex C. Towns ◽

Johannes Tigges ◽

Margarete Tigges

Keyword(s):

Visual Cortex ◽

Squirrel Monkey ◽

Occipital Cortex ◽

Area 17 ◽

Intralaminar Nuclei ◽

Layer I

AbstractThe projection of the thalamic intralaminar nuclei (ILN) upon the visual cortex in the squirrel monkey was studied using anterograde, autoradiographic techniques. In area 17, the ILN afferents terminate in the inner and outer portions of lamina V, whereas in areas 18 and 19 the fibers terminate more diffusely along the laminae V–VI boundary. Widespread labeling of layer I is seen throughout the occipital cortex.

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The cortical projections of the thalamic intralaminar nuclei restudied by means of the HRP retrograde axonal transport

Neuroscience Letters ◽

10.1016/0304-3940(77)90126-4 ◽

1977 ◽

Vol 4 (3-4) ◽

pp. 121-126 ◽

Cited By ~ 82

Author(s):

Giorgio Macchi ◽

Marina Bentivoglio ◽

Clara D'Atena ◽

Paolo Rossini ◽

Enrico Tempesta

Keyword(s):

Axonal Transport ◽

Retrograde Axonal Transport ◽

Intralaminar Nuclei ◽

Cortical Projections

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Respiratory alkalosis provokes spike-wave discharges in seizure-prone rats

eLife ◽

10.7554/elife.72898 ◽

2022 ◽

Vol 11 ◽

Author(s):

Kathryn A Salvati ◽

George MPR Souza ◽

Adam C Lu ◽

Matthew L Ritger ◽

Patrice Guyenet ◽

...

Keyword(s):

Respiratory Alkalosis ◽

Absence Epilepsy ◽

Ph Sensitive ◽

Absence Seizure ◽

Patient Response ◽

Absence Seizures ◽

Intralaminar Nuclei ◽

Highly Sensitive ◽

Intralaminar Thalamus ◽

Spike Wave Discharges

Hyperventilation reliably provokes seizures in patients diagnosed with absence epilepsy. Despite this predictable patient response, the mechanisms that enable hyperventilation to powerfully activate absence seizure-generating circuits remain entirely unknown. By utilizing gas exchange manipulations and optogenetics in the WAG/Rij rat, an established rodent model of absence epilepsy, we demonstrate that absence seizures are highly sensitive to arterial carbon dioxide, suggesting that seizure-generating circuits are sensitive to pH. Moreover, hyperventilation consistently activated neurons within the intralaminar nuclei of the thalamus, a structure implicated in seizure generation. We show that intralaminar thalamus also contains pH-sensitive neurons. Collectively, these observations suggest that hyperventilation activates pH-sensitive neurons of the intralaminar nuclei to provoke absence seizures.

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